Spectrum and functional validation of PSMB5 mutations in multiple myeloma
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A. Rosenwald | E. Leich | H. Einsele | R. Beckmann | E. Braggio | A. Stewart | C. Barrio-García | Andoni Garitano-Trojaola | R. Bargou | M. Chatterjee | T. Stühmer | K. M. Kortüm | M. Raab | J. Martínez-López | A. Bešše | C. Driessen | S. Barrio | N. Lehners | Severin Fink | M. Da-Via | A. Stewart | I. Cuenca | J. Martínez‐López | Isabel Cuenca
[1] T. Arndt. Crystal , 2019, Springer Reference Medizin.
[2] G. Morgan,et al. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma , 2017, Leukemia.
[3] Yuan-Xiao Zhu,et al. CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma , 2017, Molecular Cancer Therapeutics.
[4] R. Fonseca,et al. Trends in overall survival and costs of multiple myeloma, 2000–2014 , 2016, Leukemia.
[5] R. Fonseca,et al. Genomic Characterization of High-Count MBL Cases Indicates that Early Detection of Driver Mutations and Subclonal Expansion are Predictors of Adverse Clinical Outcome , 2016, Leukemia.
[6] L. Garraway,et al. Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers , 2016, Proceedings of the National Academy of Sciences.
[7] Erich A. Peterson,et al. Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma. , 2016, Blood.
[8] H. Goldschmidt,et al. Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes. , 2016, Blood.
[9] Ricardo A. Mata,et al. The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design , 2016, Science.
[10] B. Everts,et al. Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism , 2016, Leukemia.
[11] G. Ahmann,et al. Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients , 2016, Blood Cancer Journal.
[12] H. Keun,et al. Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97 , 2015, Cell Death and Disease.
[13] Gordon Cook,et al. Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] Marc L. Mendillo,et al. Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome , 2015, eLife.
[15] H. Einsele,et al. Loss of Serum and Glucocorticoid-Regulated Kinase 3 (SGK3) Does Not Affect Proliferation and Survival of Multiple Myeloma Cell Lines , 2015, PloS one.
[16] C. Curtis,et al. A Big Bang model of human colorectal tumor growth , 2015, Nature Genetics.
[17] J. Sacchettini,et al. Crystal structure of the human 20S proteasome in complex with carfilzomib. , 2015, Structure.
[18] M. Groll,et al. Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914. , 2015, Structure.
[19] N. Potter,et al. Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma , 2014, Leukemia.
[20] R. Deshaies,et al. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition , 2013, bioRxiv.
[21] G. Parmigiani,et al. Heterogeneity of genomic evolution and mutational profiles in multiple myeloma , 2014, Nature Communications.
[22] A. McKenna,et al. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. , 2014, Cancer cell.
[23] A Rosenwald,et al. Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules , 2013, Blood Cancer Journal.
[24] G. Mulligan,et al. Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone. , 2012, Blood.
[25] Michael L. Wang,et al. Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. , 2012, Blood.
[26] J. Carpten,et al. Clonal competition with alternating dominance in multiple myeloma. , 2012, Blood.
[27] J. Carpten,et al. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. , 2012, Blood.
[28] G. Peters,et al. Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis , 2012, Journal of Pharmacology and Experimental Therapeutics.
[29] J. Naval,et al. Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. , 2012, Leukemia research.
[30] S. Demo,et al. Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma Cells , 2011, PloS one.
[31] Jianmin Wang,et al. Upregulated expression of the PSMB5 gene may contribute to drug resistance in patient with multiple myeloma when treated with bortezomib-based regimen. , 2011, Experimental hematology.
[32] J. Keats,et al. RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. , 2009, Blood.
[33] R. Deshaies,et al. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. , 2010, Molecular cell.
[34] Seamus J. Martin,et al. Expression, purification and use of recombinant annexin V for the detection of apoptotic cells , 2009, Nature Protocols.
[35] G. Peters,et al. Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. , 2008, Blood.
[36] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[37] D. Chauhan,et al. Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. , 2003, Cancer research.