Immuno-engineered mRNA combined with cell adhesive niche for synergistic modulation of the MSC secretome.

[1]  W. Lim.  The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function , 2022, Science.

[2]  K. Chien,et al.  VEGFA mRNA for regenerative treatment of heart failure , 2021, Nature reviews. Drug discovery.

[3]  Yi-Tao Yu,et al.  The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines , 2021, Frontiers in Cell and Developmental Biology.

[4]  M. Gossen,et al.  Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells , 2021, Biofabrication.

[5]  K. Anseth,et al.  Engineering the MSC Secretome: A Hydrogel Focused Approach , 2021, Advanced Healthcare Materials.

[6]  J. Mascola,et al.  Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine , 2020, The New England journal of medicine.

[7]  B. Rodriguez,et al.  Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose , 2020, Proceedings of the National Academy of Sciences.

[8]  D. Mooney,et al.  Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects. , 2019, Biomaterials.

[9]  Joshua D. Jones,et al.  Pseudouridinylation of mRNA coding sequences alters translation , 2019, Proceedings of the National Academy of Sciences.

[10]  Angelo S. Mao,et al.  Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation , 2019, Proceedings of the National Academy of Sciences.

[11]  K. Chien,et al.  Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes , 2019, Nature Communications.

[12]  Jin-Soo Kim,et al.  Unexpected CRISPR on-target effects , 2018, Nature Biotechnology.

[13]  D. Mooney,et al.  Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs. , 2017, Biomaterials.

[14]  Angelo S. Mao,et al.  Deterministic encapsulation of single cells in thin tunable microgels for niche modeling and therapeutic delivery , 2016, Nature materials.

[15]  Richard W Farndale,et al.  Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry , 2016, Journal of Materials Science: Materials in Medicine.

[16]  Asher Mullard.  mRNA-based drug approaches Phase I milestone , 2016, Nature Reviews Drug Discovery.

[17]  D. Mooney,et al.  Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. , 2016, Biomaterials.

[18]  Bin Li,et al.  Effects of Chemically Modified Messenger RNA on Protein Expression. , 2016, Bioconjugate chemistry.

[19]  R. Weiss,et al.  N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[20]  T. Schlake,et al.  Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[21]  C. Rice,et al.  To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes , 2015, Trends in Cell Biology.

[22]  Y. Taniyama,et al.  Gene therapy in peripheral artery disease , 2015, Expert opinion on biological therapy.

[23]  Seahyoung Lee,et al.  Cell Adhesion and Long-Term Survival of Transplanted Mesenchymal Stem Cells: A Prerequisite for Cell Therapy , 2015, Oxidative medicine and cellular longevity.

[24]  Dilip Thomas,et al.  A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells. , 2014, Biomaterials.

[25]  Özlem Türeci,et al.  mRNA-based therapeutics — developing a new class of drugs , 2014, Nature Reviews Drug Discovery.

[26]  G. Malaponte,et al.  Inflammation and peripheral arterial disease: the value of circulating biomarkers (Review). , 2014, International journal of molecular medicine.

[27]  Mehmet Fatih Yanik,et al.  mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. , 2013, Blood.

[28]  J. Hare,et al.  Advances in cell-based therapy for peripheral vascular disease. , 2012, Atherosclerosis.

[29]  T. O’Brien,et al.  Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia , 2012, Stem Cell Research & Therapy.

[30]  Claudia Cattoglio,et al.  Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. , 2012, The Journal of clinical investigation.

[31]  D. Walsh,et al.  Viral subversion of the host protein synthesis machinery , 2011, Nature Reviews Microbiology.

[32]  D. Weissman,et al.  Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L , 2011, Nucleic acids research.

[33]  A. Caplan,et al.  The MSC: an injury drugstore. , 2011, Cell stem cell.

[34]  S. Ikeda,et al.  A Simple, Highly Efficient Method for Heterologous Expression in Mammalian Primary Neurons Using Cationic Lipid-mediated mRNA Transfection , 2010, Front. Neurosci..

[35]  Philip C. Bevilacqua,et al.  Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation , 2010, Nucleic acids research.

[36]  Z. Han,et al.  Cross‐talk between the VEGF‐A and HGF signalling pathways in endothelial cells , 2009, Biology of the cell.

[37]  A. Smit,et al.  Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. , 2006, Human gene therapy.

[38]  E. Boerwinkle,et al.  Plasma MCP-1 level and risk for peripheral arterial disease and incident coronary heart disease: Atherosclerosis Risk in Communities study. , 2005, Atherosclerosis.

[39]  Houping Ni,et al.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. , 2005, Immunity.

[40]  Sergio Romagnani,et al.  An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4 , 2003, The Journal of experimental medicine.

[41]  J. Mosca,et al.  Characterization and functionality of cell surface molecules on human mesenchymal stem cells. , 2003, Journal of biomedical science.

[42]  S. Ylä-Herttuala,et al.  Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ , 2002, The journal of gene medicine.

[43]  J. Garcia,et al.  Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β , 2002 .

[44]  J. Isner,et al.  Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor , 2000, Annals of Internal Medicine.

[45]  M. Matsuzaki,et al.  Enhancement of angiogenesis by the implantation of self bone marrow cells in a rat ischemic heart model. , 2000, The Journal of surgical research.

[46]  S. Frisch,et al.  Disruption of epithelial cell-matrix interactions induces apoptosis , 1994, The Journal of cell biology.

[47]  R. Henschler,et al.  Fate of intravenously injected mesenchymal stem cells and significance for clinical application. , 2013, Advances in biochemical engineering/biotechnology.