Perspectives in Diabetes Hypothesis : Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome

“The stability of the internal environment is the condition that life should be free and independent. . . So, far from the higher animal being indifferent to the external world, it is on the contrary in a precise and informed relation with it, in such a way that its equilibrium results from a continuous and delicate compensation, established as by the most sensitive of balances.” Claude Bernard (1865)

[1]  A. Kalsbeek,et al.  The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons , 2003, The Journal of comparative neurology.

[2]  A. Folsom,et al.  Prospective Investigation of Autonomic Nervous System Function and the Development of Type 2 Diabetes: The Atherosclerosis Risk In Communities Study, 1987–1998 , 2003, Circulation.

[3]  R. Marfella,et al.  Sympathovagal balance, nighttime blood pressure, and QT intervals in normotensive obese women. , 2003, Obesity research.

[4]  M. Aktoz,et al.  Decreased nocturnal synthesis of melatonin in patients with coronary artery disease. , 2003, International journal of cardiology.

[5]  F. Vaida,et al.  Age and temporal trends of total physical activity in Swedish men. , 2003, Medicine and science in sports and exercise.

[6]  S. Babighian,et al.  Autonomic System Activity and 24-Hour Blood Pressure Variations in Subjects with Normal- and High-Tension Glaucoma , 2003, Journal of glaucoma.

[7]  T. Åkerstedt,et al.  Endocrine responses to nocturnal eating – possible implications for night work , 2003, European journal of nutrition.

[8]  E. Keller,et al.  Alterations in height, weight, and body mass index of newborns, children, and young adults in eastern Germany after German reunification. , 2003, The Journal of pediatrics.

[9]  S. L. la Fleur,et al.  Daily Rhythms in Glucose Metabolism: Suprachiasmatic Nucleus Output to Peripheral Tissue , 2003, Journal of neuroendocrinology.

[10]  N. Pørksen Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes. , 2002, Diabetes, nutrition & metabolism.

[11]  R. Marfella,et al.  Autonomic dysfunction associates with prolongation of QT intervals and blunted night BP in obese women with visceral obesity , 2002, Journal of endocrinological investigation.

[12]  L. Rossetti,et al.  Hypothalamic insulin signaling is required for inhibition of glucose production , 2002, Nature Medicine.

[13]  S. Beske,et al.  Sympathetic Neural Activation in Visceral Obesity , 2002, Circulation.

[14]  A. Kalsbeek,et al.  Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications. , 2002, The Journal of clinical investigation.

[15]  K. Stewart,et al.  Exercise training and the cardiovascular consequences of type 2 diabetes and hypertension: plausible mechanisms for improving cardiovascular health. , 2002, JAMA.

[16]  T. Alquier,et al.  Brain glucose sensing mechanism and glucose homeostasis , 2002, Current opinion in clinical nutrition and metabolic care.

[17]  Anna Maria Siega-Riz,et al.  Trends in food locations and sources among adolescents and young adults. , 2002, Preventive medicine.

[18]  A. Craig How do you feel? Interoception: the sense of the physiological condition of the body , 2002, Nature Reviews Neuroscience.

[19]  S. Tanada,et al.  An epidemiological study on relationship between the hours of sleep and life style factors in Japanese factory workers. , 2002, Journal of physiological anthropology and applied human science.

[20]  P. Hsieh,et al.  Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. , 2002, American journal of physiology. Endocrinology and metabolism.

[21]  Zhaohui Feng,et al.  Central administration of oleic acid inhibits glucose production and food intake. , 2002, Diabetes.

[22]  A. Gauthier,et al.  Effects of regular training at the same time of day on diurnal fluctuations in muscular performance , 2002, Journal of sports sciences.

[23]  T. Kigoshi,et al.  INSULIN RESISTANCE IS ASSOCIATED WITH REDUCED NOCTURNAL FALLS OF BLOOD PRESSURE IN NORMOTENSIVE, NONOBESE TYPE 2 DIABETIC SUBJECTS , 2002, Clinical and experimental hypertension.

[24]  Tom Baranowski,et al.  Eating Patterns, Dietary Quality and Obesity , 2001, Journal of the American College of Nutrition.

[25]  H. Hirao,et al.  Calorie Restriction Reduced Blood Pressure in Obesity Hypertensives by Improvement of Autonomic Nerve Activity and Insulin Sensitivity , 2001, Journal of cardiovascular pharmacology.

[26]  T. Moritani,et al.  Exercise training and autonomic nervous system activity in obese individuals. , 2001, Medicine and science in sports and exercise.

[27]  W. Lautt,et al.  Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[28]  A. Kalsbeek,et al.  Hypothalamic integration of central and peripheral clocks , 2001, Nature Reviews Neuroscience.

[29]  T. Ishikawa,et al.  Investigation on diabetic autonomic neuropathy assessed by power spectral analysis of heart rate variability in WBN/Kob rats. , 2001, Journal of electrocardiology.

[30]  J Wortel,et al.  A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. , 2001, Diabetes.

[31]  B. Popkin,et al.  The increasing prevalence of snacking among US children from 1977 to 1996. , 2001, The Journal of pediatrics.

[32]  D. Swaab,et al.  Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock , 2001, The Journal of comparative neurology.

[33]  C. Mogensen,et al.  Autonomic neuropathy in nondiabetic offspring of type 2 diabetic subjects is associated with urinary albumin excretion rate and 24-h ambulatory blood pressure: the Fredericia Study. , 2001, Diabetes.

[34]  P. Perin,et al.  SYMPATHETIC NERVOUS SYSTEM, DIABETES, AND HYPERTENSION , 2001, Clinical and experimental hypertension.

[35]  T. Imaizumi,et al.  Depressor effect by exercise training is associated with amelioration of hyperinsulinemia and sympathetic overactivity. , 2000, Internal medicine.

[36]  A. Kalsbeek,et al.  Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver , 2000, Brain Research.

[37]  A. Timmis,et al.  Autonomic dysfunction is related to impaired pancreatic β cell function in patients with coronary artery disease , 2000, Heart.

[38]  H. Sei,et al.  Spontaneous activity, sleep, and body temperature in rats lacking the CCK-A receptor , 1999, Physiology & Behavior.

[39]  M. Polansky,et al.  Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes. , 1999, Diabetes.

[40]  P. Stein,et al.  Effect of exercise training on heart rate variability in healthy older adults. , 1999, American heart journal.

[41]  H. Romijn,et al.  Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway , 1999, The European journal of neuroscience.

[42]  C. Saper,et al.  From Lesions to Leptin Hypothalamic Control of Food Intake and Body Weight , 1999, Neuron.

[43]  D. Swaab,et al.  Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain , 1998, The Journal of comparative neurology.

[44]  N. Lynch,et al.  Temporal specificity in adaptations to high-intensity exercise training. , 1998, Medicine and science in sports and exercise.

[45]  T. Barbieri,et al.  Effect of Exercise and Dietary Restraint on Energy Intake of Reduced-Obese Women , 1996, Appetite.

[46]  M. Hofman,et al.  Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging , 1994, Brain Research.

[47]  L. Bernardi,et al.  Relationship Between the Circadian Rhythms of Blood Pressure and Sympathovagal Balance in Diabetic Autonomic Neuropathy , 1993, Diabetes.

[48]  F. Assimacopoulos-Jeannet,et al.  The importance of the brain in the aetiology of obesity and type 2 diabetes. , 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[49]  P. Fratino,et al.  Impaired Circadian Modulation of Sympathovagal Activity in Diabetes: A Possible Explanation for Altered Temporal Onset of Cardiovascular Disease , 1992, Circulation.

[50]  B. Jeanrenaud,et al.  Aspects of neuroregulation of body composition and insulin secretion. , 1991, International journal of obesity.

[51]  F. Moses The Effect of Exercise on the Gastrointestinal Tract , 1990, Sports medicine.

[52]  H. R. Peterson,et al.  Body fat and the activity of the autonomic nervous system. , 1988, The New England journal of medicine.

[53]  J. Mitchell,et al.  Regional distribution of blood flow of dogs during graded dynamic exercise. , 1987, Journal of applied physiology.

[54]  B. Jeanrenaud,et al.  An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause , 1985, Diabetologia.

[55]  P. Sawchenko,et al.  Evidence for hepatic involvement in control of ad libitum food intake in rats. , 1984, The American journal of physiology.

[56]  J. Arendt,et al.  ABNORMAL CIRCADIAN RHYTHM OF MELATONIN IN DIABETIC AUTONOMIC NEUROPATHY , 1984, Clinical endocrinology.

[57]  P. Björntorp PHYSIOLOGICAL AND CLINICAL ASPECTS OF EXERCISE IN OBESE PERSONS , 1983, Exercise and sport sciences reviews.

[58]  J. Neel Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? , 1962, American journal of human genetics.

[59]  Tim S Olds,et al.  Secular Trends in the Performance of Children and Adolescents (1980–2000) , 2003, Sports medicine.

[60]  N. Pørksen,et al.  The in vivo regulation of pulsatile insulin secretion , 2002, Diabetologia.

[61]  A. Cincotta,et al.  Circadian rhythms regulate the- expression of the thrifty genotypelphenotype , 1996 .

[62]  G. Bray,et al.  Obesity--a state of reduced sympathetic activity and normal or high adrenal activity (the autonomic and adrenal hypothesis revisited). , 1990, International journal of obesity.

[63]  R. L. Rizek,et al.  Diets of American women, in 1985. , 1989, The Bulletin of the Michigan Dental Hygienists' Association.

[64]  A. Matsumoto,et al.  Printed in U.S.A. Copyright © 2000 by The Endocrine Society Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat* , 2022 .