Human milk: processing and conservation – a review

Human milk has a balance of nutrients and bioactive compounds, and it must be the exclusive food source during the first six months of the infant's life. In cases where the woman is unable to breastfeed, due to hypogalactia or pre-existing disease, the use of donated human milk, available in human milk banks, is recommended. Currently, in the human milk banks the processing applied for greater conservation is Holder pasteurization. Therefore, the objective of this work is to perform a search in the literature about new possible treatments to be applied to human milk, and its influence on its physical-chemical composition; and in this sense, the studied processes were: Holder pasteurization, lyophilization, spray-drying, high hydrostatic pressure, high temperature and short time, and short wave ultraviolet irradiation. For that, a search was performed in databases, and 126 articles were selected to carry out this review according to the keywords used. It was observed that the studied treatments can be applied for the processing and conservation of human milk, once it was applied in matrices with similar composition.

[1]  D. Lacks,et al.  Physicochemical properties of spray-dried mango phenolic compounds extracts , 2020 .

[2]  Biniam Kebede,et al.  Impact of freeze-drying and subsequent storage on milk metabolites based on 1H NMR and UHPLC-QToF/MS , 2020 .

[3]  J. García-Parra,et al.  Bacillus cereus spores and Staphylococcus aureus sub. aureus vegetative cells inactivation in human milk by high-pressure processing , 2020 .

[4]  S. Tassou,et al.  A systematic review on the recent advances of the energy efficiency improvements in non-conventional food drying technologies , 2020, Trends in Food Science & Technology.

[5]  V. Briard-Bion,et al.  Differential impact of Holder and High Temperature Short Time pasteurization on the dynamic in vitro digestion of human milk in a preterm newborn model. , 2020, Food chemistry.

[6]  A. Sanz-Medel,et al.  Impact of Holder pasteurization on essential elements from human donor milk: Total contents and protein-binding profiles , 2020 .

[7]  Adriela A. Rydlewski,et al.  Métodos analíticos utilizados para a determinação de lipídios em leite humano: uma revisão , 2020 .

[8]  L. Cavallarin,et al.  Effect of Alternative Pasteurization Techniques On Human Milk's Bioactive Proteins. , 2019, Journal of pediatric gastroenterology and nutrition.

[9]  A. A. Tribst,et al.  High pressure processing impacts on the hydrolytic profile of milk coagulants , 2019, Food Bioscience.

[10]  Roberto Pisano,et al.  Achieving Continuous Manufacturing in Lyophilization: Technologies and Approaches. , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[11]  P. Middleton,et al.  Changes to breast milk fatty acid composition during storage, handling and processing: A systematic review. , 2019, Prostaglandins, leukotrienes, and essential fatty acids.

[12]  P. Zhou,et al.  Changes in milk fat globule membrane proteome after pasteurization in human, bovine and caprine species. , 2019, Food chemistry.

[13]  R. Montanari,et al.  UV irradiation as a comparable method to thermal treatment for producing high quality stabilized milk whey , 2019, LWT.

[14]  J. Moses,et al.  Spray freeze drying: Emerging applications in drug delivery. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[15]  J. M. Franco,et al.  The Importance of Understanding the Freezing Step and Its Impact on Freeze-Drying Process Performance. , 2019, Journal of pharmaceutical sciences.

[16]  K. Skorupska,et al.  Microwave heat treatment application to pasteurization of human milk , 2019, Innovative Food Science & Emerging Technologies.

[17]  M. Farid,et al.  Investigate the efficacy of UV pretreatment on thermal inactivation of Bacillus subtilis spores in different types of milk , 2019, Innovative Food Science & Emerging Technologies.

[18]  A. Kiss,et al.  High Hydrostatic Pressure Processing Better Preserves the Nutrient and Bioactive Compound Composition of Human Donor Milk. , 2019, The Journal of nutrition.

[19]  A. Kelly,et al.  Atomisation technologies used in spray drying in the dairy industry: A review , 2019, Journal of Food Engineering.

[20]  Ahmad B. Albadarin,et al.  Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[21]  J. Visentainer,et al.  Lipids and Fatty Acids in Human Milk: Benefits and Analysis , 2018, Biochemistry and Health Benefits of Fatty Acids.

[22]  L. Couëdelo,et al.  A New High Hydrostatic Pressure Process to Assure the Microbial Safety of Human Milk While Preserving the Biological Activity of Its Main Components , 2018, Front. Public Health.

[23]  D. Lembo,et al.  High Temperature—Short Time Pasteurization Has a Lower Impact on the Antiviral Properties of Human Milk Than Holder Pasteurization , 2018, Front. Pediatr..

[24]  J. M. Rodríguez,et al.  Effect of HTST and Holder Pasteurization on the Concentration of Immunoglobulins, Growth Factors, and Hormones in Donor Human Milk , 2018, Front. Immunol..

[25]  H. Panchal,et al.  Solar energy utilisation for milk pasteurisation: A comprehensive review , 2018, Renewable and Sustainable Energy Reviews.

[26]  Changlu Ma,et al.  Comparative proteomics analysis of human and ruminant milk serum reveals variation in protection and nutrition. , 2018, Food chemistry.

[27]  D. Spatz.  Pasteurized Donor Human Milk and Milk Banking Through the Human Milk Banking Association of North America. , 2018, Journal of obstetric, gynecologic, and neonatal nursing : JOGNN.

[28]  Miguel Calvo Rebollar,et al.  Effect of thermal and high-pressure treatments on the antirotaviral activity of human milk fractions , 2018, Innovative Food Science & Emerging Technologies.

[29]  M. Lacroix,et al.  Assessment of the Biological Activity in Human Milk Power Treated with Different Processes for Their Conservation , 2018 .

[30]  J. M. Rodríguez,et al.  High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting , 2018, Front. Microbiol..

[31]  M. Drake,et al.  The effect of spray drying on the difference in flavor and functional properties of liquid and dried whey proteins, milk proteins, and micellar casein concentrates. , 2018, Journal of dairy science.

[32]  U. Kulozik,et al.  Temperature-controlled microwave-vacuum drying of lactic acid bacteria: Impact of drying conditions on process and product characteristics , 2018 .

[33]  T. Fang,et al.  Newly designed superheated steam dryer bearing heat recovery unit: Analysis of energy efficiency and kinetics of Kelp drying , 2018 .

[34]  P. Polidori,et al.  Effects of freeze-drying and spray-drying on donkey milk volatile compounds and whey proteins stability , 2018 .

[35]  L. G. Costa,et al.  OPGr o53 - Taxa de descarte de leite humano e fatores relacionados , 2017 .

[36]  S. Rankin,et al.  A 100-Year Review: A century of dairy processing advancements-Pasteurization, cleaning and sanitation, and sanitary equipment design. , 2017, Journal of dairy science.

[37]  W. Hattori,et al.  Quality of human milk expressed in a human milk bank and at home. , 2017, Jornal de pediatria.

[38]  Rosa Elena Pérez Hernández,et al.  Impacto de la pasteurización/liofilización en el contenido disponible de inmunoglobulinas en leche humana madura. Estudio de aplicación en bancos de leche humana en hospitales , 2017 .

[39]  Arlan Caldas Pereira Silveira,et al.  Thermodynamic characterization of single-stage spray dryers: Mass and energy balances for milk drying , 2017 .

[40]  P. Teixeira,et al.  Development of probiotic fruit juice powders by spray-drying: A review , 2017 .

[41]  Wei Chen,et al.  Trends of spray drying: A critical review on drying of fruit and vegetable juices , 2017 .

[42]  C. Boccolini,et al.  Prevalence and factors associated with breast milk donation in banks that receive human milk in primary health care units. , 2017, Jornal de pediatria.

[43]  A. Singhal,et al.  Optimizing Nutrition in Preterm Low Birth Weight Infants—Consensus Summary , 2017, Front. Nutr..

[44]  G. Jan,et al.  Spray drying of probiotics and other food-grade bacteria: A review , 2017 .

[45]  R. Hentschel,et al.  High‐temperature short‐time pasteurisation of human breastmilk is efficient in retaining protein and reducing the bacterial count , 2017, Acta paediatrica.

[46]  D. Cavouras,et al.  Factors affecting human colostrum fatty acid profile: A case study , 2017, PloS one.

[47]  A. Ghafoor,et al.  Study of the Drying Behavior and Performance Evaluation of Gas Fired Hybrid Solar Dryer , 2017 .

[48]  A. Amini,et al.  Performance analysis of heat pump and infrared–heat pump drying of grated carrot using energy-exergy methodology , 2017 .

[49]  T. Jensen,et al.  Breast Milk Stem Cells: Current Science and Implications for Preterm Infants , 2016, Advances in neonatal care : official journal of the National Association of Neonatal Nurses.

[50]  D. Dupont,et al.  Holder pasteurization impacts the proteolysis, lipolysis and disintegration of human milk under in vitro dynamic term newborn digestion , 2016 .

[51]  E. Bertino,et al.  Pasteurization of human milk by a benchtop High-Temperature Short-Time device , 2016 .

[52]  E. Bertino,et al.  The Effect of Holder Pasteurization on Nutrients and Biologically-Active Components in Donor Human Milk: A Review , 2016, Nutrients.

[53]  H. García,et al.  Effect of Pasteurization, Freeze-drying and Spray Drying on the Fat Globule and Lipid Profile of Human Milk , 2016 .

[54]  I. Delgadillo,et al.  Human Milk Composition and Preservation: Evaluation of High-pressure Processing as a Nonthermal Pasteurization Technology , 2016, Critical reviews in food science and nutrition.

[55]  Xinyu Wang,et al.  Comparative proteomics of milk fat globule membrane in different species reveals variations in lactation and nutrition. , 2016, Food chemistry.

[56]  J. García-Parra,et al.  Volatile profile of breast milk subjected to high-pressure processing or thermal treatment. , 2015, Food chemistry.

[57]  T. Ashmeade,et al.  Improving Human Milk and Breastfeeding Practices in the NICU. , 2015, Journal of obstetric, gynecologic, and neonatal nursing : JOGNN.

[58]  J. Ewaschuk,et al.  Human milk pasteurization: benefits and risks , 2015, Current opinion in clinical nutrition and metabolic care.

[59]  R. Carabias-Martínez,et al.  Analysis of free nucleotide monophosphates in human milk and effect of pasteurisation or high-pressure processing on their contents by capillary electrophoresis coupled to mass spectrometry. , 2015, Food chemistry.

[60]  R. Katke,et al.  Practicalities and benefits of human milk banks in India , 2015, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[61]  M. Martínez-Lorenzo,et al.  Kinetic parameters for high-pressure-induced denaturation of lactoferrin in human milk , 2014 .

[62]  A. H. D. N. Rangel,et al.  Qualidade do leite bovino nas diferentes estações do ano no estado do Rio Grande do Norte , 2014 .

[63]  A. Castellote,et al.  Vitamins, fatty acids, and antioxidant capacity stability during storage of freeze-dried human milk , 2014, International journal of food sciences and nutrition.

[64]  H. Viernstein,et al.  Effect of lyoprotectants on β-glucosidase activity and viability of Bifidobacterium infantis after freeze-drying and storage in milk and low pH juices , 2014 .

[65]  R. Cava,et al.  Tocopherols, fatty acids and cytokines content of holder pasteurised and high-pressure processed human milk , 2014 .

[66]  P. Hartmann,et al.  The Effect of UV-C Pasteurization on Bacteriostatic Properties and Immunological Proteins of Donor Human Milk , 2013, PloS one.

[67]  R. Cava,et al.  Effect of thermal pasteurisation or high pressure processing on immunoglobulin and leukocyte contents of human milk , 2013 .

[68]  P. Hartmann,et al.  Ultraviolet-C Irradiation: A Novel Pasteurization Method for Donor Human Milk , 2013, PloS one.

[69]  J. Guerrero-Beltrán,et al.  Drying Kinetics of Paddy in a Reduced Pressure Superheated Steam Fluidized Bed , 2013 .

[70]  A. Morrow,et al.  Human milk composition: nutrients and bioactive factors. , 2013, Pediatric clinics of North America.

[71]  S. Fenton,et al.  Researching chemicals in human milk can be conducted without discouraging breastfeeding. , 2012, Bosnian journal of basic medical sciences.

[72]  Paolo Polidori,et al.  Effects of Lyophilization and Use of Probiotics on Donkey's Milk Nutritional Characteristics , 2011 .

[73]  M. Permanyer,et al.  Effects of pasteurisation and high-pressure processing on vitamin C, tocopherols and fatty acids in mature human milk , 2011 .

[74]  George Srzednicki,et al.  Drying of Beef in Superheated Steam , 2010 .

[75]  J. Meinzen-Derr,et al.  Alterations in the Host Defense Properties of Human Milk Following Prolonged Storage or Pasteurization , 2010, Journal of pediatric gastroenterology and nutrition.

[76]  F. Pérez-Cano,et al.  Banked human milk treatment and immunoactive factors content. Comparison with high pressure processing , 2010, Proceedings of the Nutrition Society.

[77]  Arun S. Mujumdar,et al.  An overview of the recent advances in spray-drying , 2010 .

[78]  W. E. Muir,et al.  Drying Kinetics of Instant Asian Noodles Processed in Superheated Steam , 2010 .

[79]  F. Pérez-Cano,et al.  Maintenance of breast milk Immunoglobulin A after high-pressure processing. , 2010, Journal of dairy science.

[80]  F. J. Romero,et al.  Frozen Breast Milk at -20°C and -80°C: A Longitudinal Study of Glutathione Peroxidase Activity and Malondialdehyde Concentration , 2010, Journal of human lactation : official journal of International Lactation Consultant Association.

[81]  J. Sagripanti,et al.  Overview of the Inactivation by 254 nm Ultraviolet Radiation of Bacteria with Particular Relevance to Biodefense , 2008, Photochemistry and photobiology.

[82]  A. Castellote,et al.  Effect of pasteurisation on ascorbic acid, dehydroascorbic acid, tocopherols and fatty acids in pooled mature human milk , 2008 .

[83]  Jonathan C Allen,et al.  Effects of High-Pressure Processing on Immunoglobulin A and Lysozyme Activity in Human Milk , 2007 .

[84]  M. Pierson,et al.  Effects of ultraviolet irradiation on chemical and sensory properties of goat milk. , 2007, Journal of dairy science.

[85]  Fokke G Terpstra,et al.  Antimicrobial and antiviral effect of high-temperature short-time (HTST) pasteurization applied to human milk. , 2007, Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.

[86]  Franz Reis Novak,et al.  Rede Nacional de Bancos de Leite Humano: gênese e evolução , 2006 .

[87]  P. Fox,et al.  High pressure-induced changes in bovine milk proteins: a review. , 2006, Biochimica et biophysica acta.

[88]  A. Eidelman,et al.  Breastfeeding and the Use of Human Milk. , 2013, Nursing for women's health.

[89]  S. V. Cançado,et al.  Comparação entre os métodos de referência e a análise eletrônica na determinação da composição do leite bovino , 2004 .

[90]  M. Farid,et al.  Ultraviolet treatment of orange juice , 2004 .

[91]  T. Langrish,et al.  An Experimental Investigation of the Wall Deposition of Milk Powder in a Pilot-Scale Spray Dryer , 2003 .

[92]  Somchart Soponronnarit,et al.  DESORPTION ISOTHERMS AND DRYING CHARACTERISTICS OF SHRIMP IN SUPERHEATED STEAM AND HOT AIR , 2002 .

[93]  Cristina Ratti,et al.  Hot air and freeze-drying of high-value foods : a review , 2001 .

[94]  M. Picciano.  Human Milk: Nutritional Aspects of a Dynamic Food , 1998, Neonatology.

[95]  K. Rajkowski,et al.  Milk pasteurisation and safety: a brief history and update. , 1997, Revue scientifique et technique.

[96]  P. Arlabosse,et al.  Drying droplet as a template for solid formation: A review , 2020 .

[97]  M. Wiedmann,et al.  Symposium review: Effect of post-pasteurization contamination on fluid milk quality. , 2018, Journal of dairy science.

[98]  M. Drake,et al.  Sensory Properties of Milk Protein Ingredients , 2016 .

[99]  B. Farkas,et al.  Inactivation of bacterial pathogens in human milk by high-pressure processing. , 2008, Journal of food protection.

[100]  B. Koletzko,et al.  Fat content and fatty acid composition of fresh, pasteurized, or sterilized human milk. , 2001, Advances in experimental medicine and biology.