Biophysics and Microphysiology of Synaptic Transmission in Hippocampus

Most of what is known about the microphysiology and biophysics of synaptic transmission has derived from the study of just three preparations: the vertebrate and arthropod neuromuscular junctions and the squid giant synapse (Katz, 1969; Martin, 1977; Takeuchi, 1977). Although the general facts and laws gleaned from these three classical preparations probably apply also to cortical synapses, this inference remains an article of faith. Furthermore, there are structural and functional specializations in the cortex that cannot readily be addressed in the three classical preparations.

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