The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Aim:  Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near‐infrared spectroscopy (NIRS)‐determined measure of frontal lobe oxygenation (ScO2) and increases middle cerebral artery mean blood velocity (MCA Vmean), suggesting α‐adrenergic‐mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

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