Endogenous digoxin-like immunoreactivity during pregnancy and at birth.

1. We have measured endogenous digoxin-like immunoreactivity (EDLI), in mothers and infants, during normal/pathological pregnancies and at birth. 2. During pregnancy, EDLI was measured in 38 maternal-fetal pairs. At the time of fetal sampling, maternal age was 29 (s.d. 6) years and gestational age was 28 (s.d. 6) weeks. EDLI was present in 13 (34%) mothers and in 27 (71%) fetuses. There was no correlation between maternal and fetal concentrations or between maternal or fetal concentrations and gestational age. 3. EDLI was measured at birth in blood samples from 45 maternal-cord pairs. Maternal age was 29 (s.d. 5) years and gestational age was 39 (s.d. 2) weeks. EDLI was present in 11 (22%) maternal and in 44 (98%) cord samples. The concentrations were significantly higher in cord than in fetal or maternal samples (P < 0.001 in both cases). 4. High cord EDLI concentrations suggest acute synthesis during delivery. Thus, the placental transfer of digoxin calculated from maternal and cord digoxin concentrations at birth may be overestimated.

[1]  M. H. Gault,et al.  Plasma conjugated androgens in a dialysis-dependent male as immunoreactive digitalis-like factors. , 1990, Clinical Nephrology.

[2]  S. Blethen,et al.  Characterization of Digoxin‐Like Materials in Human Cord Serum , 1990, Annals of the New York Academy of Sciences.

[3]  C. Cipolloni,et al.  Endogenous digitalis-like factors: their possible pathophysiological implications with particular regard to the perinatal period. , 1990, Child nephrology and urology.

[4]  P. Jakobi,et al.  Digoxin-like immunoreactive factor measurements in pregnant women treated with digoxin because of fetal indications. , 1989, American Journal of Obstetrics and Gynecology.

[5]  S. Okamoto,et al.  Biochemical characterization of a digitalis-like substance in human urine, partially purified by high pressure liquid chromatography. , 1989, The Cardiology.

[6]  L. Poston,et al.  A comparison of endogenous digoxin-like immunoreactivity and sodium transport inhibitory activity in umbilical arterial and venous serum. , 1988, Clinical science.

[7]  P. Dandona,et al.  Secretion of atrial natriuretic peptide and digoxin-like immunoreactive substance during pregnancy. , 1988, Clinical chemistry.

[8]  G. Koren,et al.  Endogenous digoxin-like substance(s) associated with uneventful and high-risk pregnancies. , 1988, Developmental Pharmacology and Therapeutics.

[9]  S. Suzuki,et al.  Natriuretic activity of digoxin-like immunoreactive substance extracted from cord blood. , 1988, Life sciences.

[10]  J. Younis,et al.  Insufficient transplacental digoxin transfer in severe hydrops fetalis. , 1987, American journal of obstetrics and gynecology.

[11]  E. B. Cochran,et al.  Digoxin-like immunoreactive substance in pregnancy. , 1987, American journal of obstetrics and gynecology.

[12]  S. Landas,et al.  Digoxin-like immunoreactive substance in fetuses with and without cardiac pathology. , 1987, American journal of obstetrics and gynecology.

[13]  L. Witherspoon,et al.  Digoxin-like substance in term pregnancy, newborns, and renal failure. , 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[15]  T. Kuroume,et al.  Digoxin- and Digitoxin-Like Immunoreactive Substances in Amniotic Fluid, Cord Blood, and Serum of Neonates , 1986, Pediatric Research.

[16]  F. Daffos,et al.  Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases. , 1985, American journal of obstetrics and gynecology.

[17]  M. H. Gault,et al.  Dehydroepiandrosterone sulfate as a digitalis like factor in plasma of healthy human adults. , 1985, Research communications in chemical pathology and pharmacology.

[18]  G. Koren,et al.  Significance of the endogenous digoxin‐like substance in infants and mothers , 1984, Clinical pharmacology and therapeutics.

[19]  J. F. Hennessy,et al.  A digoxin-like immunoreactive substance in preeclampsia. , 1984, American journal of obstetrics and gynecology.

[20]  H. R. Craig,et al.  Endogenous digoxin-immunoreactive substance in human pregnancies. , 1984, The Journal of clinical endocrinology and metabolism.