An efficient and green method for the synthesis of N-phosphoramino o-hydroxylphenyl α-aminophosphonic monoesters

An efficient and green method to the synthesis of N-protected o-hydroxylphenyl α-amino-alkylphosphonic monoesters is described. It consists of the three-component Mannich-type reaction of phosphoramides, carbonyl compounds (aldehydes or ketones), and 2-chlorobenzo[1,3,2] diox-aphospholes under solvent-free and catalyst-free conditions, followed by hydrolysis. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:596–601, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20483

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