A Case of Maxillary Diffuse Large B Cell Lymphoma Induced to Headache in Behçet's Disease

Behcet’s disease is chronic and systemic inflammatory vasculitis, characterized by immunologically involving in variable size of arteries and veins. Clinically, principal manifestations are recurrent oral ulcer, genital ulcer, skin and eye lesions. Compared to other connective tissue disease, cancer is not accompanied commonly in Behcet`s disease. But, immunological confusion such as T cell depletion or B cell hyperplasia, or long-term of immunosuppressive treatment lead to occurrence of malignancy. Recently, we experienced a case of maxillary mass, induced to abrupt headache in Behcet’s disease, confirmed diffuse large B cell lymphoma by biopsy, and treated by rituximab-CHOP chemotherapy. Thus we report these with literature review.

[1]  Y. Katayama,et al.  Central nervous system malignant lymphoma associated with Behcet's disease. Case report. , 2005, Neurologia medico-chirurgica.

[2]  V. Kaklamani,et al.  Behçet's disease associated with malignancies. Report of two cases and review of the literature. , 2005, Clinical and experimental rheumatology.

[3]  A. Schnatter,et al.  AN ANALYSIS OF THE RISK OF B-LYMPHOCYTE MALIGNANCIES IN INDUSTRIAL COHORTS , 2003, Journal of toxicology and environmental health. Part A.

[4]  H. Direskeneli Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51 , 2001, Annals of the rheumatic diseases.

[5]  M. Erman,et al.  Cyclophosphamide-Associated Carcinoma of the Urinary Bladder in Behçet’s Disease , 1999, Nephron.

[6]  P. Hartge,et al.  Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome. AIDS/Cancer Study Group. , 1996, Journal of the National Cancer Institute.

[7]  M. Fukayama,et al.  Epstein-Barr virus in pyothorax-associated pleural lymphoma. , 1993, The American journal of pathology.

[8]  A. Yachi,et al.  Gastric non-Hodgkin's lymphoma associated with Behçet's disease. , 1993, Internal medicine.

[9]  B. Armstrong,et al.  Cancer in connective tissue disease. , 1982, Arthritis and rheumatism.

[10]  H. Nakajima,et al.  BEHÇET SYNDROME ASSOCIATED WITH NASAL MALIGNANT LYMPHOMA – REPORT OF AN AUTOPSY CASE – , 1974, Acta pathologica japonica.

[11]  P. Mummaneni,et al.  Report of two cases and review of the literature , 2004 .

[12]  E. Ozyar,et al.  Malignancy in Behçet’s Disease: A Report of 13 Cases and a Review of the Literature , 2001, Clinical Rheumatology.