Estimation of Respiratory Rate From ECG, Photoplethysmogram, and Piezoelectric Pulse Transducer Signals: A Comparative Study of Time–Frequency Methods

We compare the performance of two different time-frequency-based breathing rate (BR) detection algorithms when used on three different physiological signals: the ECG, the photoplethysmogram (PPG), and the piezoelectric pulse transducer (PZO) signal. Studies carried out over the past have shown the existence of amplitude and/or FMs due to respiration in physiological signals, such as those mentioned. In a recent study, we analyzed the PPG signal and detected the FM and amplitude modulation effect that controlled breathing had on it, and inferred the rate of respiration using the time-frequency spectrum (TFS) (via a wavelet (WT) or complex demodulation (CDM) approach). We showed that such TFS BR detection methods were very accurate and consistently outperformed the exclusively time-domain autoregressive modeling (AR) method, especially in the real-time (data length of 1 min) case. We now explore the possibility of using these methods on the ECG and the finger PZO signal, of which only the former has been previously used with some success to derive BR. Testing performed on 15 healthy human subjects for a range of BR and two body positions showed that though the PPG signal gave the most consistently high performance, the ECG and PZO also proved to be reasonably accurate over longer time segments. Furthermore, the CDM approach was on average either better than or comparable to the WT method in terms of both accuracy and repeatability of the detection.

[1]  Claire Médigue,et al.  Instantaneous parameter estimation in cardiovascular time series by harmonic and time-frequency analysis , 2002, IEEE Transactions on Biomedical Engineering.

[2]  L. Nilsson,et al.  Combined photoplethysmographic monitoring of respiration rate and pulse: a comparison between different measurement sites in spontaneously breathing subjects , 2007, Acta anaesthesiologica Scandinavica.

[3]  B. Hök,et al.  Critical review of non-invasive respiratory monitoring in medical care , 2003, Medical and Biological Engineering and Computing.

[4]  S. Janson,et al.  Estimated prevalences of respiratory symptoms, asthma and chronic obstructive pulmonary disease related to detection rate in primary health care. , 2001, Scandinavian journal of primary health care.

[5]  J. N. Watson,et al.  An Algorithm for the Detection of Individual Breaths from the Pulse Oximeter Waveform , 2004, Journal of clinical monitoring and computing.

[6]  J. N. Watson,et al.  An automated algorithm for determining respiratory rate by photoplethysmogram in children , 2006, Acta paediatrica.

[7]  L. Nilsson,et al.  Respiration can be monitored by photoplethysmography with high sensitivity and specificity regardless of anaesthesia and ventilatory mode , 2005, Acta anaesthesiologica Scandinavica.

[8]  E. J. Bowers,et al.  Principal Component Analysis as a Tool for Analysing Beat-to-Beat Changes in Electrocardiogram Features: Application to Electrocardiogram Derived Respiration , 2009 .

[9]  M J Tobin,et al.  Subjective and objective measurement of tidal volume in critically ill patients. , 1985, Chest.

[10]  Yuquan Chen,et al.  A piezopolymer finger pulse and breathing wave sensor , 1990 .

[11]  Y. P. Huang,et al.  Noninvasive respiratory monitoring system based on the piezoceramic transducer's pyroelectric effect. , 2008, The Review of scientific instruments.

[12]  Martin J. Tobin,et al.  Subjective and Objective Measurement of Tidal Volume in Critically III Patients , 1985 .

[13]  D. Southall,et al.  Increased amplitude modulation of continuous respiration precedes sudden infant death syndrome -detection by spectral estimation of respirogram. , 1998, Early human development.

[14]  K. Chon,et al.  A High Resolution Approach to Estimating Time-Frequency Spectra and Their Amplitudes , 2006, Annals of Biomedical Engineering.

[15]  M. Younes,et al.  Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. , 2008, Journal of applied physiology.

[16]  Susannah G. Fleming Lionel Tarassenko A Comparison of Signal Processing Techniques for the Extraction of Breathing Rate from the Photoplethysmogram , 2007 .

[17]  J. N. Watson,et al.  Measurement Of Respiratory Rate From the Photoplethysmogram In Chest Clinic Patients , 2007, Journal of clinical monitoring and computing.

[18]  L. Nilsson,et al.  Monitoring of respiratory rate in postoperative care using a new photoplethysmographic technique , 2004, Journal of Clinical Monitoring and Computing.

[19]  K. Nakajima,et al.  Monitoring of heart and respiratory rates by photoplethysmography using a digital filtering technique. , 1996, Medical engineering & physics.

[20]  Philip Langley,et al.  Principal Component Analysis as a Tool for Analyzing Beat-to-Beat Changes in ECG Features: Application to ECG-Derived Respiration , 2010, IEEE Transactions on Biomedical Engineering.

[21]  J. N. Watson,et al.  Secondary wavelet feature decoupling (SWFD) and its use in detecting patient respiration from the photoplethysmogram , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

[22]  Pablo Laguna,et al.  A robust method for ECG-based estimation of the respiratory frequency during stress testing , 2006, IEEE Transactions on Biomedical Engineering.

[23]  J. N. Watson,et al.  Standard pulse oximeters can be used to monitor respiratory rate , 2003, Emergency medicine journal : EMJ.

[24]  A. Johansson,et al.  Monitoring of Heart and Respiratory Rates in Newborn Infants Using a New Photoplethysmographic Technique , 1999, Journal of Clinical Monitoring and Computing.

[25]  Ki H. Chon,et al.  Estimation of Respiratory Rate From Photoplethysmogram Data Using Time–Frequency Spectral Estimation , 2009, IEEE Transactions on Biomedical Engineering.

[26]  Shinichi Sato,et al.  System for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer , 2006, Medical and Biological Engineering and Computing.

[27]  A. Awad,et al.  The Use of Joint Time Frequency Analysis to Quantify the Effect of Ventilation on the Pulse Oximeter Waveform , 2006, Journal of Clinical Monitoring and Computing.