Studies on the Synthesis of Imidazole-metal Complexes and Their Characterization and Binding Mechanism with DNA

Three hexakis(imidazole)metallo complexes of Co, Cd and Ni were synthesized and spectroscopically characterized. The crystal and molecular structures have been determined by X-ray crystallography analysis. The metal ions have an octahedral geometry with the MN6 chromophore. The electrochemical experimental results indicate that both [Co(Im)6]Cl2·2HCl·2H2O (1) and [Ni(Im)6]Cl2·4H2O (3) [Imimidazole] could interact with DNA mainly by intercalation.

[1]  D. Pang,et al.  Spectroscopic and voltammetric study on the binding of aluminium(III) to DNA. , 2002, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[2]  H. Fun,et al.  Hexakis(imidazole-N3)nickel(II) bis(4-methoxybenzoate). , 2000, Acta crystallographica. Section C, Crystal structure communications.

[3]  C. Bailly,et al.  Oxidation of CuII to CuIII, Free Radical Production, and DNA Cleavage by Hydroxy-salen−Copper Complexes. Isomeric Effects Studied by ESR and Electrochemistry , 1999 .

[4]  Nanqiang Li,et al.  Electrochemical studies of porphyrin interacting with DNA and determination of DNA , 1997 .

[5]  S. Dong,et al.  Interaction of brilliant cresyl blue and methylene green with DNA studied by spectrophotometric and voltammetric methods , 1996 .

[6]  V. Bloomfield,et al.  Competitive Electrostatic Binding of Charged Ligands to Polyelectrolytes: Planar and Cylindrical Geometries , 1996 .

[7]  Bryant S. Fujimoto,et al.  Fluorescence and photobleaching studies of methylene blue binding to DNA , 1994, Photonics West - Lasers and Applications in Science and Engineering.

[8]  C. Kumar,et al.  DNA binding studies and site selective fluorescence sensitization of an anthryl probe , 1993 .

[9]  C. Woods,et al.  Synthesis, spectroscopic and structural characterization of bis(acetato)tetrakis(imidazole)copper(II): a model complex for DNA binding , 1992 .

[10]  A. Bard,et al.  Electrochemical studies of the interaction of metal chelates with DNA. 4. Voltammetric and electrogenerated chemiluminescent studies of the interaction of tris(2,2'-bipyridine)osmium(II) with DNA. , 1990, Analytical chemistry.

[11]  T. Tidwell.  Ketene chemistry: the second golden age , 1990 .

[12]  Michael T. Carter,et al.  Voltammetric studies of the interaction of metal chelates with DNA. 2. Tris-chelated complexes of cobalt(III) and iron(II) with 1,10-phenanthroline and 2,2'-bipyridine , 1989 .

[13]  Hiroshi Tamura,et al.  A new antitumor complex: bis(acetato)bis(imidazole)copper(II) , 1987 .

[14]  D. McConnell,et al.  Methylene blue photosensitised strand cleavage of DNA: effects of dye binding and oxygen. , 1987, Nucleic acids research.

[15]  W. Horrocks,et al.  Models for cobalt(II)-substituted zinc metalloenzymes. 1. Comparison of the crystal structures of complexes of the type: [M(RCOO)2(Im)2] (Im = imidazole; M = Co, Zn; R = CH3, C2H5) , 1982 .

[16]  W. H. Burton,et al.  Potential causal prophylactic antimalarial agents. Synthesis of quinoxaline, benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety , 1978 .

[17]  C. Hubbard,et al.  Hexakis(imidazole)nickel(II) chloride tetrahydrate , 1976 .

[18]  N. Davidson,et al.  Mercury(II) Complexes of Imidazole and Histidine , 1960 .

[19]  L. Rogers,et al.  Determination of Water Vapor in Nitrogen. Thermal Conductivity Measurement of Hydrogen Liberated from Calcium Hydride , 1958 .