Ligand and cation binding are dual functions of a discrete segment of the integrin β 3 subunit: Cation displacement is involved in ligand binding

[1]  Jeffrey W. Smith,et al.  A mechanism for divalent cation regulation of beta 3-integrins. , 1994, The Journal of biological chemistry.

[2]  L. Parise,et al.  Regulation of vascular integrins. , 1993, Blood.

[3]  F. Pochon,et al.  On the mechanism of energy transfer to Tb3+ ions in proteins. A time-resolved luminescence study of the Tb-elastase complex. , 1993, European journal of biochemistry.

[4]  Y. Takada,et al.  A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques , 1992, The Journal of cell biology.

[5]  T. Yip,et al.  Occupancy of a C2‐C2 type ‘Zinc‐finger’ protein domain by copper Direct observation by electrospray ionization mass spectrometry , 1992, FEBS letters.

[6]  C. Hogue,et al.  Comparison of terbium (III) luminescence enhancement in mutants of EF hand calcium binding proteins. , 1992, The Journal of biological chemistry.

[7]  A. Brass,et al.  Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site. , 1992, The Biochemical journal.

[8]  T. K. Gartner,et al.  A peptide corresponding to GPIIb alpha 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligands. , 1992, The Journal of biological chemistry.

[9]  G. Davis,et al.  Regulation of alpha 2 beta 1-mediated fibroblast migration on type I collagen by shifts in the concentrations of extracellular Mg2+ and Ca2+ [published erratum appears in J Cell Biol 1992 Jul;118(1):219] , 1992, The Journal of cell biology.

[10]  S. Kent,et al.  Direct observation of a ternary complex between the dimeric enzyme HIV-1 protease and a substrate-based inhibitor , 1992 .

[11]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[12]  N. Hogg,et al.  Divalent cation regulation of the function of the leukocyte integrin LFA-1 , 1992, The Journal of cell biology.

[13]  S. D’Souza,et al.  Ligand Binding to GPIIb-IIIa: A Status Report , 1992, Seminars in thrombosis and hemostasis.

[14]  M. Horton,et al.  Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface , 1991, The Journal of cell biology.

[15]  A. Chapel,et al.  A highly conserved sequence of the Arg-Gly-Asp-binding domain of the integrin beta 3 subunit is sensitive to stimulation. , 1991, Journal of Biological Chemistry.

[16]  D. Cheresh,et al.  Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding. , 1991, The Journal of biological chemistry.

[17]  B. Savage,et al.  Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. , 1991, The Journal of biological chemistry.

[18]  J. González-Rodríguez,et al.  Calcium binding to human platelet integrin GPIIb/IIIa and to its constituent glycoproteins. Effects of lipids and temperature. , 1991, The Biochemical journal.

[19]  Xiaoping Du,et al.  Ligands “activate” integrin α IIb β 3 (platelet GPIIb-IIIa) , 1991, Cell.

[20]  M. Ginsberg,et al.  A discrete sequence in a platelet integrin is involved in ligand recognition , 1991, Nature.

[21]  D. Kirchhofer,et al.  Calcium as a potential physiological regulator of integrin-mediated cell adhesion. , 1991, The Journal of biological chemistry.

[22]  C. Figdor,et al.  Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion , 1991, The Journal of cell biology.

[23]  A. Frelinger,et al.  A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. , 1990, Science.

[24]  A. Frelinger,et al.  Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. , 1990, The Journal of biological chemistry.

[25]  M. Ginsberg,et al.  The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. , 1990, The Journal of biological chemistry.

[26]  M. Horton,et al.  The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor , 1989, The Journal of cell biology.

[27]  P. Hadváry,et al.  Ca2+-dependent binding of a synthetic Arg-Gly-Asp (RGD) peptide to a single site on the purified platelet glycoprotein IIb-IIIa complex. , 1989, The Journal of biological chemistry.

[28]  W. Carter,et al.  The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++- dependent adhesion of platelets to collagen , 1989, The Journal of cell biology.

[29]  M. James,et al.  Crystal structures of the helix-loop-helix calcium-binding proteins. , 1989, Annual review of biochemistry.

[30]  J W Smith,et al.  The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. , 1988, The Journal of biological chemistry.

[31]  S. Lam,et al.  Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. , 1988, Science.

[32]  S. Ott,et al.  Purification of murine IgG3 and IgM monoclonal antibodies by euglobulin precipitation. , 1988, Journal of immunological methods.

[33]  L. Parise,et al.  LA Fitzgerald The platelet membrane glycoprotein IIb-IIIa complex , 1988 .

[34]  J. Calvete,et al.  Tryptic digestion of human GPIIIa. Isolation and biochemical characterization of the 23 kDa N-terminal glycopeptide carrying the antigenic determinant for a monoclonal antibody (P37) which inhibits platelet aggregation. , 1988, The Biochemical journal.

[35]  E Ruoslahti,et al.  New perspectives in cell adhesion: RGD and integrins. , 1987, Science.

[36]  D. Cheresh.  Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[37]  J. Goding,et al.  Monoclonal Antibodies: Principles and Practice , 1996 .

[38]  A. Kaufmann,et al.  Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. , 1986, The Journal of clinical investigation.

[39]  E. Ruoslahti,et al.  Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. , 1985, The Journal of biological chemistry.

[40]  E. Plow,et al.  THE FIBRINOGEN‐DEPENDENT PATHWAY OF PLATELET AGGREGATION * , 1983, Annals of the New York Academy of Sciences.

[41]  S. Timmons,et al.  Recognition site for the platelet receptor is present on the 15-residue carboxy-terminal fragment of the gamma chain of human fibrinogen and is not involved in the fibrin polymerization reaction. , 1983, Thrombosis research.

[42]  S. Timmons,et al.  Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen gamma chain. , 1982, Biochemical and biophysical research communications.

[43]  E. Plow,et al.  Inhibition of fibrinogen binding to human platelets by the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Snyder,et al.  Lanthanide ion luminescence probes. Characterization of metal ion binding sites and intermetal energy transfer distance measurements in calcium-binding proteins. 2. Thermolysin. , 1981, Biochemistry.

[45]  E. Plow,et al.  Interaction of fibrinogen with its platelet receptor: kinetics and effect of pH and temperature. , 1981, Biochemistry.

[46]  T. Edgington,et al.  Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. , 1980, The Journal of biological chemistry.

[47]  M. Morrison.  Lactoperoxidase-catalyzed iodination as a tool for investigation of proteins. , 1980, Methods in enzymology.

[48]  R. Martin,et al.  Terbium (III) emission as a probe of calcium(II) binding sites in proteins. , 1976, Journal of the American Chemical Society.

[49]  R. Martin,et al.  Lanthanide complexes of amino acids , 1974 .