Influence of cobalt doping on the hyperthermic efficiency of magnetite nanoparticles

Abstract Magnetite nanoparticles (NPs) are extensively investigated for biomedical applications, particularly as contrast agents for Magnetic Resonance Imaging and as heat mediators in Magnetic Fluid Hyperthermia. For the latter, one of the goal of the research is to obtain materials with improved hyperthermic properties. A valuable strategy is the increase of the magnetic anisotropy of commonly employed magnetite through the total or partial substitution of Fe 2+ ions with Co 2+ ions. Here we present a study on a family of 8 nm Co-doped magnetite NPs (Co x Fe 3− x O 4 ), with composition ranging from pure magnetite ( x =0) to stoichiometric cobalt ferrite ( x =1), aimed to investigate the evolution of the hyperthermic properties with the increase of Co content. We found that the addition of a small amount of Co is enough to sharply increase the Specific Absorption Rate (SAR). The SAR further increases with x but it reaches a maximum for an intermediate value ( x =0.6). Such anomalous behavior is ascribed to the intrinsic magnetic properties of the material, and, in particular, to the magnetic anisotropy, which displays the same peculiar trend. The Co-doping thus may represent an effective strategy to improve the poor hyperthermic efficiency of very small magnetite NPs (

[1]  S. Pennycook,et al.  Surfactant organic molecules restore magnetism in metal-oxide nanoparticle surfaces. , 2012, Nano letters.

[2]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[3]  Sébastien Lachaize,et al.  Optimal Size of Nanoparticles for Magnetic Hyperthermia: A Combined Theoretical and Experimental Study , 2011 .

[4]  Gabriel Shemer,et al.  Tuning a Colloidal Synthesis to Control Co2+ Doping in Ferrite Nanocrystals , 2007 .

[5]  J. Bacri,et al.  Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. , 2007, Journal of the American Chemical Society.

[6]  C. Innocenti,et al.  A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. , 2014, ACS nano.

[7]  A. Barron,et al.  Reagent control over the size, uniformity, and composition of Co–Fe–O nanoparticles , 2008 .

[8]  A. Arrott,et al.  Ferromagnetic materials : a handbook on the properties of magnetically ordered substances , 1982 .

[9]  C. Bárcena,et al.  APPLICATIONS OF MAGNETIC NANOPARTICLES IN BIOMEDICINE , 2003 .

[10]  D. Dhawale,et al.  Polyvinyl alcohol functionalized cobalt ferrite nanoparticles for biomedical applications , 2013 .

[11]  C. Fernández Influence of the temperature dependence of anisotropy on the magnetic behavior of nanoparticles , 2005 .

[12]  Catherine C. Berry,et al.  Progress in functionalization of magnetic nanoparticles for applications in biomedicine , 2009 .

[13]  C. Berndt,et al.  Biocompatibility of transition metal-substituted cobalt ferrite nanoparticles , 2014, Journal of Nanoparticle Research.

[14]  Matthias Zeisberger,et al.  Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia. , 2009, Journal of magnetism and magnetic materials.

[15]  J. Dormann,et al.  Magnetic Relaxation in Fine‐Particle Systems , 2007 .

[16]  T. Choli-Papadopoulou,et al.  Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses. , 2014, Dalton transactions.

[17]  A. Lascialfari,et al.  Bovine serum albumin-based magnetic nanocarrier for MRI diagnosis and hyperthermic therapy: a potential theranostic approach against cancer. , 2010, Small.

[18]  Hao Zeng,et al.  Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. , 2004, Journal of the American Chemical Society.

[19]  S. Dutz,et al.  Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy , 2007 .

[20]  P. Wust,et al.  Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme , 2010, Journal of Neuro-Oncology.

[21]  Raju V. Ramanujan,et al.  Modeling the performance of magnetic nanoparticles in multimodal cancer therapy , 2010 .

[22]  Masashi Tachiki,et al.  Origin of the Magnetic Anisotropy Energy of Cobalt Ferrite , 1960 .

[23]  Thomas Meade,et al.  Effects of shape and size of cobalt ferrite nanostructures on their MRI contrast and thermal activation. , 2009, The journal of physical chemistry. C, Nanomaterials and interfaces.

[24]  M. Franchini,et al.  Synthesis and coating of cobalt ferrite nanoparticles: a first step toward the obtainment of new magnetic nanocarriers. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[25]  C. Rinaldi,et al.  A Statistical Analysis to Control the Growth of Cobalt Ferrite Nanoparticles Synthesized by the Thermodecomposition Method , 2010 .

[26]  Oded Maimon,et al.  Predictive Toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data , 2013, Particle and Fibre Toxicology.

[27]  K. Knížek,et al.  Magnetic heating by cobalt ferrite nanoparticles , 2007 .

[28]  C. Innocenti,et al.  Water-dispersible sugar-coated iron oxide nanoparticles. An evaluation of their relaxometric and magnetic hyperthermia properties. , 2011, Journal of the American Chemical Society.

[29]  Brianna N. Peeples,et al.  Structural, stability, magnetic, and toxicity studies of nanocrystalline iron oxide and cobalt ferrites for biomedical applications , 2014, Journal of Nanoparticle Research.

[30]  Soonhag Kim,et al.  Gene Expression Profiles for Genotoxic Effects of Silica-Free and Silica-Coated Cobalt Ferrite Nanoparticles , 2012, The Journal of Nuclear Medicine.

[31]  Lucía Gutiérrez,et al.  Biological applications of magnetic nanoparticles. , 2012, Chemical Society reviews.

[32]  Peter Wust,et al.  Magnetic nanoparticle hyperthermia for prostate cancer , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[33]  Qing Ma,et al.  Probing the Chemical Stability of Mixed Ferrites: Implications for Magnetic Resonance Contrast Agent Design , 2011 .

[34]  Q. Pankhurst,et al.  Progress in applications of magnetic nanoparticles in biomedicine , 2009 .

[35]  C. Innocenti,et al.  Exploring the Effect of Co Doping in Fine Maghemite Nanoparticles , 2012 .