A comprehensive characterisation of the metabolic profile of varicose veins; implications in elaborating plausible cellular pathways for disease pathogenesis

[1]  A. Davies,et al.  Optimization of metabolite extraction of human vein tissue for ultra performance liquid chromatography-mass spectrometry and nuclear magnetic resonance-based untargeted metabolic profiling. , 2015, The Analyst.

[2]  A. Davies,et al.  Untargeted UPLC-MS Profiling Pipeline to Expand Tissue Metabolome Coverage: Application to Cardiovascular Disease , 2015, Analytical chemistry.

[3]  J. Nicholson,et al.  In-vitro identification of distinctive metabolic signatures of intact varicose vein tissue via magic angle spinning nuclear magnetic resonance spectroscopy. , 2012, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[4]  J. Das,et al.  Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats , 2012, Amino Acids.

[5]  A. Bielawska,et al.  Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation* , 2011, The Journal of Biological Chemistry.

[6]  B. Friguet,et al.  Muscle Creatine Kinase Deficiency Triggers Both Actin Depolymerization and Desmin Disorganization by Advanced Glycation End Products in Dilated Cardiomyopathy* , 2011, The Journal of Biological Chemistry.

[7]  M. Setou,et al.  Imaging mass spectrometry reveals unique lipid distribution in primary varicose veins. , 2010, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[8]  Elaine Holmes,et al.  High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues , 2010, Nature Protocols.

[9]  J. Raffetto,et al.  Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins. , 2010, Journal of vascular surgery.

[10]  A. Davies,et al.  Pathogenesis of primary varicose veins , 2009, The British journal of surgery.

[11]  I. Kubota,et al.  Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade. , 2008, American journal of physiology. Heart and circulatory physiology.

[12]  Donald G Robertson,et al.  Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity. , 2007, Analytical chemistry.

[13]  H. Senn,et al.  Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics. , 2006, Analytical chemistry.

[14]  J. Lindon,et al.  Pharmaco-metabonomic phenotyping and personalized drug treatment , 2006, Nature.

[15]  R. Abagyan,et al.  XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. , 2006, Analytical chemistry.

[16]  G. Moneta,et al.  Revision of the CEAP classification for chronic venous disorders: consensus statement. , 2004, Journal of vascular surgery.

[17]  J. Brouwers,et al.  Identification of a family of animal sphingomyelin synthases , 2004, The EMBO journal.

[18]  R. Curi,et al.  Glutamine and glutamate—their central role in cell metabolism and function , 2003, Cell biochemistry and function.

[19]  Y. Benjamini,et al.  THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .

[20]  J. Fitzpatrick,et al.  Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent. , 2000, Shock.

[21]  J. Lindon,et al.  'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.

[22]  R. Curi,et al.  The importance of fuel metabolism to macrophage function , 1996, Cell biochemistry and function.

[23]  C. Kent,et al.  Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines. , 1995, Archives of biochemistry and biophysics.

[24]  D. Perl,et al.  Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease , 1995, Nature Genetics.

[25]  Y. Hannun,et al.  Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. , 1992, The Journal of biological chemistry.

[26]  J. Broadhead,et al.  WHO consensus statement. , 1990, The British journal of psychiatry : the journal of mental science.

[27]  Francis J. Haddy,et al.  Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia , 1977, Pflügers Archiv.

[28]  S. Gatt ENZYMIC HYDROLYSIS AND SYNTHESIS OF CERAMIDES. , 1963, The Journal of biological chemistry.

[29]  H. Eagle,et al.  Myo-Inositol as an essential growth factor for normal and malignant human cells in tissue culture. , 1956, The Journal of biological chemistry.

[30]  E. Want,et al.  HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies. , 2011, Analytical chemistry.

[31]  F. Vesuna,et al.  Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. , 2008, Cancer research.

[32]  H. Ripps,et al.  Review: Taurine: A “very essential” amino acid , 2012, Molecular vision.