Circadian system — A novel diagnostic and therapeutic target in Parkinson's disease?

The circadian system regulates biological rhythmicity in the human body. The role of the circadian system in neurological disorders is a theme that is attracting an increasing amount of interest from the scientific community. This has arisen, in part, from emerging evidence that disorders such as Parkinson's disease (PD) are multifactorial with many features exhibiting diurnal fluctuations, thereby suggestive of circadian involvement. Although the importance of fluctuating motor and nonmotor manifestations in PD have been well acknowledged, the role of the circadian system has received little attention until recently. It is proposed that intervening with circadian function provides a novel research avenue down which new strategies for improving symptomatic treatment and slowing of the progressive degenerative process can be approached to lessen the burden of PD. In this article we review the literature describing existing circadian research in PD and its experimental models. © 2016 International Parkinson and Movement Disorder Society

[1]  G. Willis,et al.  Primary and Secondary Features of Parkinson's Disease Improve with Strategic Exposure to Bright Light: A Case Series Study , 2007, Chronobiology international.

[2]  E. Maywood,et al.  Circadian clocks: regulators of endocrine and metabolic rhythms. , 2007, The Journal of endocrinology.

[3]  B. Bruguerolle,et al.  EFFECTS OF L-DOPA ON CIRCADIAN RHYTHMS OF 6-OHDA STRIATAL LESIONED RATS: A RADIOTELEMETRIC STUDY , 2010, Chronobiology international.

[4]  K. Wakabayashi,et al.  Neuropathology of autonomic nervous system in Parkinson's disease. , 1997, European neurology.

[5]  H. Lennernäs,et al.  Circadian Rhythmicity in Levodopa Pharmacokinetics in Patients With Parkinson Disease , 2010, Clinical neuropharmacology.

[6]  R. Rodnitzky,et al.  Circadian fluctuations of contrast sensitivity in Parkinson's disease , 1990, Neurology.

[7]  Derk-Jan Dijk,et al.  Functional Genomics of Sleep and Circadian Rhythm Invited Review : Integration of human sleep-wake regulation and circadian rhythmicity , 2001 .

[8]  H. Pijl,et al.  Diurnal Secretion Profiles of Growth Hormone, Thyrotrophin and Prolactin in Parkinson’s Disease , 2011, Journal of neuroendocrinology.

[9]  J. Larsen,et al.  A community‐based study of sleep disorders in patients with Parkinson's disease , 1998, Movement disorders : official journal of the Movement Disorder Society.

[10]  L. Harrell,et al.  The effects of dark and light on the functional recovery following lateral hypothalamic lesions. , 1974, Life sciences.

[11]  S. Ohdo,et al.  A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease , 2013, NeuroMolecular Medicine.

[12]  T. Schmitz-Hübsch,et al.  Bright light therapy in Parkinson's disease: A pilot study , 2007, Movement disorders : official journal of the Movement Disorder Society.

[13]  R. Roos,et al.  Diurnal effects of motor activity and fatigue in Parkinson's disease. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[14]  A. Davies,et al.  Circadian rest‐activity rhythm is altered in Parkinson's disease patients with hallucinations , 2008, Movement disorders : official journal of the Movement Disorder Society.

[15]  J. A. Madrid,et al.  Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model , 2012, Chronobiology international.

[16]  G. Willis.  Intraocular microinjections repair experimental Parkinson's disease , 2008, Brain Research.

[17]  C. Colwell,et al.  Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: Insights from a transgenic mouse model , 2013, Experimental Neurology.

[18]  M. A. Hofman,et al.  THE HUMAN CIRCADIAN CLOCK AND AGING , 2000, Chronobiology international.

[19]  Urs P Mosimann,et al.  The retina in Parkinson's disease. , 2009, Brain : a journal of neurology.

[20]  R. Roos,et al.  A new approach in the assessment of motor activity in Parkinson's disease. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[21]  G. Linazasoro,et al.  Nocturnal akathisia in parkinson's disease: Treatment with clozapine , 1993, Movement disorders : official journal of the Movement Disorder Society.

[22]  P. Pasqualetti,et al.  Sleep-wake cycle and effects of cabergoline monotherapy in de novo Parkinson’s disease patients , 2008, Journal of Neurology.

[23]  S. Amir,et al.  Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D2 Dopamine Receptors , 2010, The Journal of Neuroscience.

[24]  Elizabeth B Klerman,et al.  Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. , 2002, American journal of physiology. Endocrinology and metabolism.

[25]  R. Barker,et al.  Sleep and circadian rhythm regulation in early Parkinson disease. , 2014, JAMA neurology.

[26]  C. Tanner,et al.  Excessive daytime sleepiness and subsequent development of Parkinson disease , 2005, Neurology.

[27]  A. Rademaker,et al.  Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. , 2014, JAMA neurology.

[28]  J W Langston,et al.  The hypothalamus in parkinson disease , 1978, Annals of neurology.

[29]  D. Weaver.  The Suprachiasmatic Nucleus: A 25-Year Retrospective , 1998, Journal of biological rhythms.

[30]  W. Weiner,et al.  Sleep disorders and sleep effect in Parkinson's disease , 1990, Movement disorders : official journal of the Movement Disorder Society.

[31]  W. Paulus,et al.  Circadian distribution of motor-activity in unilaterally 6-hydroxy-dopamine lesioned rats , 2006, Experimental Brain Research.

[32]  Joseph F Rizzo,et al.  Nonphotic entrainment of the human circadian pacemaker. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[33]  N. A. Blackburn,et al.  The nighttime problems of Parkinson's disease. , 1988, Clinical neuropharmacology.

[34]  Ushodaya Mattam,et al.  Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson’s disease male Wistar rat model and effect of melatonin administration , 2014, Biogerontology.

[35]  P. Piccini,et al.  [Diurnal worsening in Parkinson patients treated with levodopa]. , 1991, Rivista di neurologia.

[36]  D. Rye,et al.  FAST TRACK: daytime sleepiness in Parkinson's disease. , 2000, Journal of sleep research.

[37]  B. Burnside,et al.  Dopaminergic Regulation of Cone Retinomotor Movement in Isolated Teleost Retinas: I. Induction of Cone Contraction Is Mediated by D2 Receptors , 1986, Journal of neurochemistry.

[38]  H. Cooper,et al.  Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease , 2014, Neurobiology of Disease.

[39]  H. Kennedy,et al.  Alteration of Daily and Circadian Rhythms following Dopamine Depletion in MPTP Treated Non-Human Primates , 2014, PloS one.

[40]  S. Yamaguchi,et al.  Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo , 2003, Science.

[41]  R. Hilker,et al.  Diurnal Variation of Hypothalamic Function and Chronic Subthalamic Nucleus Stimulation in Parkinson's Disease , 2012, Neuroendocrinology.

[42]  G. Fabbrini,et al.  Excessive daytime somnolence in Parkinson’s disease. Follow-up after 1 year of treatment , 2003, Neurological Sciences.

[43]  P. Piccini,et al.  Diurnal Motor Variations to Repeated Doses of Levodopa in Parkinson's Disease , 2000, Clinical neuropharmacology.

[44]  A. Robertson,et al.  Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor , 2004, Pharmacology Biochemistry and Behavior.

[45]  Fumitoshi Niwa,et al.  Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease , 2011, Autonomic Neuroscience.

[46]  Ann C McKee,et al.  Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[47]  R. Sandyk,et al.  The hypothalamus in Parkinson's disease. , 1987, The International journal of neuroscience.

[48]  E. Haus,et al.  ALTERATIONS WITH AGING OF THE ENDOCRINE AND NEUROENDOCRINE CIRCADIAN SYSTEM IN HUMANS , 2000, Chronobiology international.

[49]  R. Roos,et al.  Sleep disruption in Parkinson's disease. Assessment by continuous activity monitoring. , 1994, Archives of neurology.

[50]  D. Yang,et al.  Association between nocturnal/supine hypertension and restless legs syndrome in patients with Parkinson's disease , 2014, Journal of the Neurological Sciences.

[51]  F. Davis,et al.  Transplanted suprachiasmatic nucleus determines circadian period. , 1990, Science.

[52]  P. Zee,et al.  Effects of age on the circadian system , 1995, Neuroscience & Biobehavioral Reviews.

[53]  C. Remé,et al.  Circadian rhythm in rat retinal dopamine , 1984, Neuroscience Letters.

[54]  D. Rye,et al.  Daytime sleepiness in Parkinson’s disease , 2000 .

[55]  A. Ashburn,et al.  Impaired bed mobility and disordered sleep in Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.

[56]  O. Dkhissi-Benyahya,et al.  Lack of long-term changes in circadian, locomotor, and cognitive functions in acute and chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse models of parkinson’s disease , 2013, Chronobiology international.

[57]  S. Overeem,et al.  Hypocretin (orexin) loss in Parkinson's disease. , 2007, Brain : a journal of neurology.

[58]  S. Amir,et al.  Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain , 2011, Journal of Molecular Neuroscience.

[59]  R. Roos,et al.  [Drug therapy in Parkinson's disease]. , 1999, Nederlands tijdschrift voor geneeskunde.

[60]  Michael W Young,et al.  Interplay of circadian clocks and metabolic rhythms. , 2006, Annual review of genetics.

[61]  D. Rye.  Sleepiness and unintended sleep in Parkinson’s disease , 2003, Current treatment options in neurology.

[62]  S. Lewis,et al.  The Relationship between Thermoregulation and REM Sleep Behaviour Disorder in Parkinson’s Disease , 2013, PloS one.

[63]  F. Waldhauser,et al.  Circadian secretion pattern of melatonin in de novo Parkinsonian patients: evidence for phase-shifting properties of l-dopa , 1993, Journal of neural transmission. Parkinson's disease and dementia section.

[64]  A. Mochizuki,et al.  Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease , 2002, Acta Neuropathologica.

[65]  C. Colwell,et al.  Circadian dysfunction in a mouse model of Parkinson's disease , 2011, Experimental Neurology.

[66]  Lihong Chen,et al.  Recent advances in circadian rhythms in cardiovascular system , 2015, Front. Pharmacol..

[67]  M. Mizobuchi,et al.  Disappearance of circadian rhythms in Parkinson's disease model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in dogs , 1992, Brain Research.

[68]  J R Hodges,et al.  Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. , 2014, Sleep medicine.

[69]  A. Ejaz,et al.  Characteristic findings on 24-h ambulatory blood pressure monitoring in a series of patients with Parkinson's disease. , 2006, European journal of internal medicine.

[70]  F. Waldhauser,et al.  Circadian secretion pattern of melatonin in Parkinson's disease , 1991, Journal of neural transmission. Parkinson's disease and dementia section.

[71]  R. Roos,et al.  Assessment of response fluctuations in Parkinson's disease by ambulatory wrist activity monitoring , 1993, Acta neurologica Scandinavica.

[72]  B. Bruguerolle,et al.  Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat: a radiotelemetric study. , 2000, Life sciences.

[73]  G. Kennedy,et al.  Compromised circadian function in Parkinson's disease: Enucleation augments disease severity in the unilateral model , 2008, Behavioural Brain Research.

[74]  Erin L. McDearmon,et al.  The genetics of mammalian circadian order and disorder: implications for physiology and disease , 2008, Nature Reviews Genetics.

[75]  M. Mizobuchi,et al.  Increase of plasma adrenocorticotrophin and cortisol in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs , 1993, Brain Research.

[76]  H. Pijl,et al.  Leptin, adiponectin, and resistin secretion and diurnal rhythmicity are unaltered in Parkinson's disease , 2011, Movement disorders : official journal of the Movement Disorder Society.

[77]  Tomoyuki Miyamoto,et al.  Circadian Variation of Core Body Temperature in Parkinson Disease Patients with Depression: A Potential Biological Marker for Depression in Parkinson Disease , 2008, Neuropsychobiology.

[78]  A. Destée,et al.  Heart rate variability and Parkinson’s disease severity , 2003, Journal of Neural Transmission.

[79]  A. Destée,et al.  Study of Circadian Melatonin Secretion Pattern at Different Stages of Parkinson's Disease , 2003, Clinical neuropharmacology.

[80]  M. Kerkhofs,et al.  Neuroendocrine rhythms and sleep in aging men. , 1991, The American journal of physiology.

[81]  G. Fabbrini,et al.  Excessive daytime sleepiness in de novo and treated Parkinson's disease , 2002, Movement disorders : official journal of the Movement Disorder Society.

[82]  S. Strogatz,et al.  Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. , 1986, Science.

[83]  C. Czeisler,et al.  Association of sleep-wake habits in older people with changes in output of circadian pacemaker , 1992, The Lancet.