MEK5/ERK5 activation regulates colon cancer stem-like cell properties

[1]  D. Widera,et al.  Inhibition of NF-κB Signaling Reduces the Stemness Characteristics of Lung Cancer Stem Cells , 2018, Front. Oncol..

[2]  G. Christofori,et al.  A kinome-wide high-content siRNA screen identifies MEK5–ERK5 signaling as critical for breast cancer cell EMT and metastasis , 2018, Oncogene.

[3]  N. Gray,et al.  Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition , 2018, Proceedings of the National Academy of Sciences.

[4]  F. Bertolini,et al.  Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status , 2017, Oncotarget.

[5]  A. Czarnecka,et al.  Three‐dimensional cell culture model utilization in cancer stem cell research , 2017, Biological reviews of the Cambridge Philosophical Society.

[6]  Greg M. Findlay,et al.  Protein Kinases in Pluripotency-Beyond the Usual Suspects. , 2017, Journal of molecular biology.

[7]  R. Weinberg,et al.  EMT, CSCs, and drug resistance: the mechanistic link and clinical implications , 2017, Nature Reviews Clinical Oncology.

[8]  Pedro M. Borralho,et al.  The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target. , 2016, Drug discovery today.

[9]  H. Tuy,et al.  ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan. , 2016, Oncology letters.

[10]  Y. Hu,et al.  ERK5 kinase activity is dispensable for cellular immune response and proliferation , 2016, Proceedings of the National Academy of Sciences.

[11]  N. Gray,et al.  Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity , 2016, Cell reports.

[12]  M. Karin,et al.  ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation , 2016, Nature Communications.

[13]  Xinlin Chen,et al.  MEK5 overexpression is associated with the occurrence and development of colorectal cancer , 2016, BMC Cancer.

[14]  T. Carvalho,et al.  MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism , 2016, Oncotarget.

[15]  W. El-Deiry,et al.  Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation. , 2016, Cancer research.

[16]  Debashis Sahoo,et al.  CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. , 2016, The New England journal of medicine.

[17]  L. Vermeulen,et al.  ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. , 2015, Cell reports.

[18]  Qiang Xu,et al.  Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L , 2015, Oncotarget.

[19]  N. Gray,et al.  Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation , 2015, Science Signaling.

[20]  D. Storm,et al.  Inducible Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis in the Olfactory Bulb and Improves Olfactory Function , 2015, The Journal of Neuroscience.

[21]  T. Carvalho,et al.  Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation , 2015, Cell Death and Disease.

[22]  B. Wittner,et al.  MAPK7 Regulates EMT Features and Modulates the Generation of CTCs , 2015, Molecular Cancer Research.

[23]  L. weiswald,et al.  Spherical Cancer Models in Tumor Biology1 , 2015, Neoplasia.

[24]  M. Todaro,et al.  Colorectal cancer stem cells: from the crypt to the clinic. , 2014, Cell stem cell.

[25]  T. Wang,et al.  XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. , 2014, Cancer letters.

[26]  Liam O'Connor,et al.  Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. , 2014, Cancer research.

[27]  A. Letai,et al.  UvA-DARE ( Digital Academic Repository ) Targeting cancer stem cells : Modulating apoptosis and stemness Çolak , 2016 .

[28]  R. Palmiter,et al.  Genetic Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis and Extends Hippocampus-Dependent Long-Term Memory , 2014, The Journal of Neuroscience.

[29]  L. Pfeffer,et al.  Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway* , 2013, The Journal of Biological Chemistry.

[30]  P. Gama,et al.  MAPKs and Signal Transduction in the Control of Gastrointestinal Epithelial Cell Proliferation and Differentiation , 2013, International journal of molecular sciences.

[31]  D. Storm,et al.  Targeted Deletion of the ERK5 MAP Kinase Impairs Neuronal Differentiation, Migration, and Survival during Adult Neurogenesis in the Olfactory Bulb , 2013, PloS one.

[32]  L. Ailles,et al.  Developmental signaling pathways in cancer stem cells of solid tumors. , 2013, Biochimica et biophysica acta.

[33]  G. Orphanides,et al.  Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines , 2012, BMC Medical Genomics.

[34]  Jurgen Müller,et al.  ERK5: structure, regulation and function. , 2012, Cellular signalling.

[35]  D. Ren,et al.  Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer , 2012, BMC Cancer.

[36]  M. J. van de Vijver,et al.  Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. , 2011, Cell stem cell.

[37]  E. Bandrés,et al.  MicroRNA‐451 Is Involved in the Self‐renewal, Tumorigenicity, and Chemoresistance of Colorectal Cancer Stem Cells , 2011, Stem cells.

[38]  Brian J. Wilson,et al.  ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. , 2011, Cancer research.

[39]  Shih-Hwa Chiou,et al.  SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. , 2011, Gastroenterology.

[40]  M. Wicha,et al.  Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots , 2011, Clinical Cancer Research.

[41]  Hans Clevers,et al.  The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.

[42]  Erika Pastrana,et al.  Eyes wide open: a critical review of sphere-formation as an assay for stem cells. , 2011, Cell stem cell.

[43]  H. Lenz,et al.  Interleukin‐8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models , 2011, International journal of cancer.

[44]  E. Nishida,et al.  ERK5 regulates muscle cell fusion through Klf transcription factors. , 2011, Developmental cell.

[45]  W. Gerald,et al.  Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling , 2011, Nature communications.

[46]  M. Lisanti,et al.  The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. , 2010, Cancer research.

[47]  J. Yates,et al.  Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. , 2010, Cancer cell.

[48]  Yingjie Yu,et al.  The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres , 2010, Molecular Cancer.

[49]  P. Moore,et al.  Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery , 2010, British Journal of Cancer.

[50]  R. Doebele,et al.  A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. , 2009, Blood.

[51]  S. Morrison,et al.  Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution , 2009, Cell.

[52]  Michael F Clarke,et al.  DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. , 2009, Cell stem cell.

[53]  Chengkun Wang,et al.  Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer , 2009, Cancer Chemotherapy and Pharmacology.

[54]  Tao Zhang,et al.  Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. , 2009, Cancer research.

[55]  Tamara Cacev,et al.  Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. , 2008, Carcinogenesis.

[56]  A. Winoto,et al.  Non‐redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis , 2008, The EMBO journal.

[57]  M. Clarke,et al.  Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy , 2008, PloS one.

[58]  M. Todaro,et al.  Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. , 2007, Cell stem cell.

[59]  Michael F. Clarke,et al.  Phenotypic characterization of human colorectal cancer stem cells , 2007, Proceedings of the National Academy of Sciences.

[60]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[61]  L. Ricci-Vitiani,et al.  Identification and expansion of human colon-cancer-initiating cells , 2007, Nature.

[62]  Irving L Weissman,et al.  Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. , 2006, Cancer research.

[63]  P. Cundiff,et al.  Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[64]  H. Konno,et al.  Association of Interleukin-8 and Plasminogen Activator System in the Progression of Colorectal Cancer , 2005, European Surgical Research.

[65]  S. Manna,et al.  Interleukin-8 Induces Nuclear Transcription Factor-κB through a TRAF6-dependent Pathway* , 2005, Journal of Biological Chemistry.

[66]  Chun Guo,et al.  Targeted Deletion of mek5 Causes Early Embryonic Death and Defects in the Extracellular Signal-Regulated Kinase 5/Myocyte Enhancer Factor 2 Cell Survival Pathway , 2005, Molecular and Cellular Biology.

[67]  A. Mercurio,et al.  The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. , 2004, Experimental cell research.

[68]  J. Arthur,et al.  Knockout of ERK5 causes multiple defects in placental and embryonic development , 2003, BMC Developmental Biology.

[69]  D. Neal,et al.  MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion , 2003, Oncogene.

[70]  A. Winoto,et al.  ERK5 MAPK Regulates Embryonic Angiogenesis and Acts as a Hypoxia-sensitive Repressor of Vascular Endothelial Growth Factor Expression* , 2002, The Journal of Biological Chemistry.

[71]  Wei Li,et al.  Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[72]  U. Rapp,et al.  Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells , 2001, EMBO reports.

[73]  Seamus J. Martin,et al.  Suppression of TNF-α-Induced Apoptosis by NF-κB , 1996, Science.

[74]  T. Murayama,et al.  [Molecular mechanism of interleukin-8 gene expression]. , 1994, Rinsho byori. The Japanese journal of clinical pathology.

[75]  K. Matsushima,et al.  Molecular mechanism of interleukin‐8 gene expression , 1994, Journal of leukocyte biology.

[76]  Takashi Ueda,et al.  Serum levels of cytokines in patients with colorectal cancer: Possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis , 1994, Journal of Gastroenterology.

[77]  W. Greene,et al.  The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[78]  Pedro M. Borralho,et al.  The MEK 5 / ERK 5 signalling pathway in cancer : a promising novel therapeutic target , 2016 .

[79]  Xuening Wang,et al.  The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage. , 2015, Experimental cell research.

[80]  S. Christmas,et al.  Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro. , 2000, Cytokine.