Quantitative analysis of necrostatin-1, a necroptosis inhibitor by LC-MS/MS and the study of its pharmacokinetics and bioavailability.

[1]  H. Duan,et al.  Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction , 2017, American Journal of Nephrology.

[2]  A. Linkermann,et al.  The in vivo evidence for regulated necrosis , 2017, Immunological reviews.

[3]  H. Park,et al.  Ischemia Reperfusion Injury Triggers TNFα Induced-Necroptosis in Rat Retina , 2017, Current eye research.

[4]  Daniel S. Chertow,et al.  Necroptosis: Mechanisms and Relevance to Disease , 2017 .

[5]  K. Okuda,et al.  Programmed necrosis - a new mechanism of steroidogenic luteal cell death and elimination during luteolysis in cows , 2016, Scientific Reports.

[6]  A. Adameová,et al.  Effects of necrostatin-1, an inhibitor of necroptosis, and its inactive analogue Nec-1i on basal cardiovascular function. , 2016, Physiological research.

[7]  A. Zhou,et al.  Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats , 2016, Scientific Reports.

[8]  H. Sawai.  Induction of Apoptosis in TNF-Treated L929 Cells in the Presence of Necrostatin-1 , 2016, International journal of molecular sciences.

[9]  Yang Zhang,et al.  Anticancer 20(R)-dammarane-3β,12β,20,25-tetrol-loaded polymeric micelles: Preparation, quantification and pharmacokinetics. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  Huimin Xu,et al.  Protective effect of necrostatin-1 on myocardial tissue in rats with acute myocardial infarction. , 2016, Genetics and molecular research : GMR.

[11]  Stefan P. Glaser,et al.  The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia , 2016, Science Translational Medicine.

[12]  J. Kers,et al.  An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury. , 2016, Seminars in nephrology.

[13]  A. Degterev,et al.  Generation of small molecules to interfere with regulated necrosis , 2016, Cellular and Molecular Life Sciences.

[14]  Yanping Han,et al.  Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis , 2016, Oncotarget.

[15]  Yunshan Guo,et al.  Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. , 2015, American journal of cancer research.

[16]  B. Zhivotovsky,et al.  Sorafenib-induced defective autophagy promotes cell death by necroptosis , 2015, Oncotarget.

[17]  Long Yang,et al.  Necrostatin-1 protection of dopaminergic neurons , 2015, Neural regeneration research.

[18]  Ruiwen Zhang,et al.  Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats. , 2015, Chinese journal of natural medicines.

[19]  Hua Gan,et al.  Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. , 2015, Biochemical and biophysical research communications.

[20]  Chuan-Qi Zhong,et al.  Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 , 2015, Nature Cell Biology.

[21]  K. Dhandapani,et al.  Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage , 2014, International journal of cell biology.

[22]  P. Gershkovich,et al.  A simple and sensitive method for determination of vitamins D3 and K1 in rat plasma: application for an in vivo pharmacokinetic study , 2014, Drug development and industrial pharmacy.

[23]  M. Kaneki,et al.  NO donor induces Nec‐1‐inhibitable, but RIP1‐independent, necrotic cell death in pancreatic β‐cells , 2011, FEBS letters.

[24]  Alexei Degterev,et al.  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury , 2005, Nature chemical biology.

[25]  J. Gertner.  Developmental changes in renal vitamin D activation , 1983 .