Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer
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M. Dowsett | S. Nik-Zainal | A. Tutt | H. Davies | A. Degasperi | M. Hubank | F. Daley | R. Roylance | N. Turner | J. Bliss | S. Chan | A. Dodson | R. Cutts | A. Pearson | N. Chopra | H. Tovey | D. Kriplani | A. Evans | A. Skene | P. Proszek | C. Toms | Heidi Gevensleben
[1] M. Dowsett,et al. Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance , 2019, Clinical Cancer Research.
[2] L. Saal,et al. Whole-genome-sequencing of triple negative breast cancers in a population-based clinical study , 2019, Nature Medicine.
[3] G. Shapiro,et al. PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. , 2019, Cancer discovery.
[4] I. Kozarewa,et al. Early ctDNA dynamics as a surrogate for progression-free survival in advanced breast cancer in the BEECH trial , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.
[5] A. Jager,et al. Direct Ex Vivo Observation of Homologous Recombination Defect Reversal After DNA-Damaging Chemotherapy in Patients With Metastatic Breast Cancer. , 2019, JCO precision oncology.
[6] A. Ashworth,et al. PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer , 2019, The Journal of clinical investigation.
[7] A. Harris,et al. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors , 2018, bioRxiv.
[8] C. Caldas,et al. A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation , 2018, EMBO molecular medicine.
[9] W. Eiermann,et al. Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation , 2018, The New England journal of medicine.
[10] Paul Ellis,et al. Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial , 2018, Nature Medicine.
[11] P. Kristel,et al. RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[12] M. Koehler,et al. Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer , 2018, Nature Communications.
[13] N. Turner. Signatures of DNA‐Repair Deficiencies in Breast Cancer , 2017, The New England journal of medicine.
[14] W. Foulkes,et al. Olaparib for Metastatic Germline BRCA-Mutated Breast Cancer. , 2017, The New England journal of medicine.
[15] Alain Viari,et al. Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency. , 2017, Cancer research.
[16] E. Lander,et al. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer , 2017, Nature Genetics.
[17] M. Robson,et al. Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation , 2017, The New England journal of medicine.
[18] J. Reis-Filho,et al. Bi‐allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer , 2017, The Journal of pathology.
[19] Sandro Morganella,et al. Mutational Signatures in Breast Cancer: The Problem at the DNA Level , 2017, Clinical Cancer Research.
[20] E. Birney,et al. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures , 2017, Nature Medicine.
[21] R. Plummer,et al. A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours , 2017, British Journal of Cancer.
[22] Alexey Sergushichev,et al. An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation , 2016 .
[23] David C. Jones,et al. Landscape of somatic mutations in 560 breast cancer whole genome sequences , 2016, Nature.
[24] Z. Szallasi,et al. Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer , 2016, Clinical Cancer Research.
[25] John M S Bartlett,et al. Abstract P1-01-01: Analytical validation of a standardized scoring protocol for Ki67: Phase-3 of an international multicenter collaboration , 2016 .
[26] Jorge S. Reis-Filho,et al. Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer , 2015, Science Translational Medicine.
[27] Mårten Fernö,et al. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease , 2015, EMBO molecular medicine.
[28] James M Ford,et al. Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[29] E. Winer,et al. TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[30] Ash A. Alizadeh,et al. Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.
[31] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[32] Paul Theodor Pyl,et al. HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.
[33] A. Sieuwerts,et al. Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment , 2014, Clinical Cancer Research.
[34] A. Tutt,et al. Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers , 2014, Breast Cancer Research.
[35] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[36] A. Vincent-Salomon,et al. Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. , 2012, Cancer research.
[37] G. Mills,et al. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer , 2012, British Journal of Cancer.
[38] A. Børresen-Dale,et al. Mutational Processes Molding the Genomes of 21 Breast Cancers , 2012, Cell.
[39] Z. Szallasi,et al. Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. , 2012, Cancer discovery.
[40] Xi Chen,et al. TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer , 2012, Cancer informatics.
[41] S. Salzberg,et al. FLASH: fast length adjustment of short reads to improve genome assemblies , 2011, Bioinform..
[42] H. Mackay,et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. , 2011, The Lancet. Oncology.
[43] A. Ashworth,et al. A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer , 2010, Clinical Cancer Research.
[44] M. Dowsett,et al. Proliferation and Apoptosis as Markers of Benefit in Neoadjuvant Endocrine Therapy of Breast Cancer , 2006, Clinical Cancer Research.
[45] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[46] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[47] M. Dowsett,et al. Comparison of the systemic and intratumoral effects of tamoxifen and the aromatase inhibitor vorozole in postmenopausal patients with primary breast cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[48] C. Osborne,et al. Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[49] S. Vispé,et al. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. , 1998, Nucleic acids research.
[50] N. Kamada,et al. S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes. , 1996, Oncogene.
[51] John N. Hutchinson,et al. Interferon Signaling is Diminished with Age and is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer. , 2019, Cancer discovery.
[52] N. Rosenfeld,et al. Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[53] M. Robson,et al. Olaparib for Metastatic Germline BRCA-Mutated Breast Cancer. , 2017, The New England journal of medicine.
[54] Anne Floquet,et al. Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. , 2017, The Lancet. Oncology.
[55] M. Hallett,et al. Absolute assignment of breast cancer intrinsic molecular subtype. , 2015, Journal of the National Cancer Institute.
[56] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[57] Wolf-Dietrich Heyer,et al. Homologous recombination in DNA repair and DNA damage tolerance , 2008, Cell Research.