Combined treatment with low‐dose methotrexate and initial short‐term superpotent topical steroids in bullous pemphigoid: an open, multicentre, retrospective study

Background  The interest of long‐term superpotent topical steroids (STS) in bullous pemphigoid (BP) has been supported by randomized controlled trials. However, inadequate compliance, poor cutaneous tolerance and nursing difficulties are potential drawbacks. Open‐label studies on limited series of patients suggested that low‐dose methotrexate (MTX) may be useful, permitting long‐term maintenance of a clinical remission obtained by initial, short‐term STS.

[1]  R. Hubbard,et al.  A population‐based study of acute medical conditions associated with bullous pemphigoid , 2009, The British journal of dermatology.

[2]  H. Gürcan,et al.  Analysis of current data on the use of methotrexate in the treatment of pemphigus and pemphigoid , 2009, The British journal of dermatology.

[3]  J. Roujeau,et al.  A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study. , 2009, The Journal of investigative dermatology.

[4]  H. Eriksson,et al.  A retrospective analysis of patients with bullous pemphigoid treated with methotrexate. , 2008, Archives of dermatology.

[5]  J. Roujeau,et al.  Prediction of survival for patients with bullous pemphigoid: a prospective study. , 2005, Archives of dermatology.

[6]  P. Hutchinson,et al.  Chlorambucil as a steroid‐sparing agent in bullous pemphigoid , 2004, The British journal of dermatology.

[7]  M. Bradley,et al.  Topical tacrolimus is a useful adjunctive therapy for bullous pemphigoid. , 2003, Archives of dermatology.

[8]  H. Maillard,et al.  Methotrexate for bullous pemphigoid: preliminary study. , 2003, Archives of dermatology.

[9]  J. Guilhou,et al.  Treatment of bullous pemphigoid by low-dose methotrexate associated with short-term potent topical steroids: an open prospective study of 18 cases. , 2002, Archives of dermatology.

[10]  M. Meurer,et al.  Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age. , 2002, Archives of dermatology.

[11]  L. Vaillant,et al.  A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. , 2002, The New England journal of medicine.

[12]  N. Korman,et al.  New immunomodulating drugs in autoimmune blistering diseases. , 2001, Dermatologic clinics.

[13]  G. Anhalt,et al.  Bullous pemphigoid treated with leflunomide: a novel immunomodulatory agent. , 2000, Archives of dermatology.

[14]  M. Kerscher,et al.  Mycophenolate mofetil: a new therapeutic option in the treatment of blistering autoimmune diseases. , 1999, Journal of the American Academy of Dermatology.

[15]  M. Kerscher,et al.  Treatment of pemphigus vulgaris and bullous pemphigoid with mycophenolate mofetil monotherapy. , 1999, Archives of dermatology.

[16]  M. Ståhle-Bäckdahl,et al.  Low-dose oral pulse methotrexate as monotherapy in elderly patients with bullous pemphigoid. , 1999, Journal of the American Academy of Dermatology.

[17]  L. Vaillant,et al.  Evaluation of clinical criteria for diagnosis of bullous pemphigoid. French Bullous Study Group. , 1998, Archives of dermatology.

[18]  J. Roujeau,et al.  High risk of death in elderly patients with extensive bullous pemphigoid. , 1998, Archives of dermatology.

[19]  T. Horio,et al.  Successful treatment of bullous pemphigoid with pulsed intravenous cyclophosphamide , 1996, The British journal of dermatology.

[20]  J. Roujeau,et al.  Treatment of bullous pemphigoid with dapsone: retrospective study of thirty-six cases. , 1996, Journal of the American Academy of Dermatology.

[21]  A. Fleischer,et al.  Low-dose methotrexate treatment in elderly patients with bullous pemphigoid. , 1994, Journal of the American Academy of Dermatology.

[22]  A. Anstey.  Controlled trial of azathioprine and plasma exchange in addition to prednisolone in the treatment of bullous pemphigoid. , 1993, Archives of dermatology.

[23]  B. Dréno,et al.  [Methylprednisolone versus prednisolone methylsulfobenzoate in pemphigoid: a comparative multicenter study]. , 1993, Annales de dermatologie et de venereologie.

[24]  A. Lorincz,et al.  The treatment of bullous pemphigoid with tetracycline and niacinamide. A preliminary report. , 1986, Archives of dermatology.

[25]  F. Cambazard,et al.  [Cyclosporin in the treatment of bullous pemphigoid: preliminary study]. , 1986, Annales de dermatologie et de venereologie.

[26]  G. Lorette,et al.  PLASMA EXCHANGE IN BULLOUS PEMPHIGOID , 1984, The Lancet.