Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties

[1]  B. Bandgar,et al.  Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. , 2010, Bioorganic & medicinal chemistry letters.

[2]  B. Bandgar,et al.  Antioxidant and anti-inflammatory related activities of selected synthetic chalcones: structure-activity relationship studies using computational tools. , 2008, Chemical & pharmaceutical bulletin.

[3]  A. Geronikaki,et al.  Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity. , 2006, Combinatorial chemistry & high throughput screening.

[4]  R. Gacche,et al.  Antioxidant and Possible Anti-Inflammatory Potential of Selected Medicinal Plants Prescribed in the Indian Traditional System of Medicine , 2006 .

[5]  R. Pratap,et al.  Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines. , 2004, Bioorganic & medicinal chemistry.

[6]  Li-Ming Zhou,et al.  Chalcones and flavonoids as anti-tuberculosis agents. , 2002, Bioorganic & medicinal chemistry.

[7]  T. Bilfinger,et al.  The role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena. , 2002, Current pharmaceutical design.

[8]  Yi Xia,et al.  Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation. , 2000 .

[9]  Yi Xia,et al.  Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation. , 2000, Bioorganic & medicinal chemistry letters.

[10]  L. Tsao,et al.  Synthesis and Anti‐inflammatory Effect of Chalcones , 2000, The Journal of pharmacy and pharmacology.

[11]  A. Izzo,et al.  Flavonoids: old and new aspects of a class of natural therapeutic drugs. , 1999, Life sciences.

[12]  A. di Pietro,et al.  Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance. , 1998, Journal of medicinal chemistry.

[13]  D. Hadjipavlou-Litina,et al.  Synthesis and biological evaluation of several coumarin-4-carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives , 1998 .

[14]  M. Alcaraz,et al.  Synthesis and anti-inflammatory activity of chalcone derivatives. , 1998, Bioorganic & medicinal chemistry letters.

[15]  N. Lawrence,et al.  Potent antimitotic and cell growth inhibitory properties of substituted chalcones. , 1998, Bioorganic & medicinal chemistry letters.

[16]  Y. Hashimoto,et al.  Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity. , 1997, Journal of medicinal chemistry.

[17]  G. Bemis,et al.  The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. , 1997, Chemistry & biology.

[18]  R. Yunes,et al.  Synthesis of Xanthoxyline Derivatives with Antinociceptive and Antioedematogenic Activities. , 1997 .

[19]  S. Iwasaki,et al.  Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production. , 1996, Biochemical and biophysical research communications.

[20]  G. Engelhardt,et al.  Distinct isoforms (COX‐1 and COX‐2) of cyclooxygenase: possible physiological and therapeutic implications , 1996, Fundamental & clinical pharmacology.

[21]  J. Gutteridge,et al.  Lipid peroxidation and antioxidants as biomarkers of tissue damage. , 1995, Clinical chemistry.

[22]  S. Iwasaki,et al.  Tumor Necrosis Factor α Production Enhancers with a Phenylphthalimide Skeleton , 1994 .

[23]  B. Varnum,et al.  TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. , 1991, The Journal of biological chemistry.

[24]  T NASH,et al.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. , 1953, The Biochemical journal.

[25]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[26]  Jeh-Jeng Wang,et al.  Synthesis and Anti-inflammatory Effect of Chalcones and Related Compounds , 2004, Pharmaceutical Research.

[27]  B. Bartolomé,et al.  In vitro antioxidant activity of red grape skins , 2004 .

[28]  Maria Novella Romanelli,et al.  Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. , 2002, Current pharmaceutical design.

[29]  J. Fruchart,et al.  Di‐tert‐butylhydroxylated flavonoids protect endothelial cells against oxidized LDL‐induced cytotoxicity , 2001, Journal of biochemical and molecular toxicology.

[30]  M. Alcaraz,et al.  4-dimethylamino-3',4'-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects. , 2001, Free radical biology & medicine.

[31]  L. Marnett Cyclooxygenase mechanisms. , 2000, Current opinion in chemical biology.

[32]  J. Vane,et al.  Mechanism of action of antiinflammatory drugs. , 1998, International journal of tissue reactions.

[33]  J. Vane,et al.  Mechanism of action of anti-inflammatory drugs. , 1997, Advances in experimental medicine and biology.

[34]  T. Bhalla,et al.  Antiinflammatory and antiproteolytic activities of newer indolyl isoquinolines. , 1982, Arzneimittel-Forschung.

[35]  D. N. Dhar The chemistry of chalcones and related compounds , 1981 .