The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

[1]  H. Hobbs,et al.  Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). , 1997, Genomics.

[2]  I. Shimomura,et al.  Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. , 1997, The Journal of clinical investigation.

[3]  J. Goldstein,et al.  Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme , 1985, Cell.

[4]  J. Goldstein,et al.  Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines , 1995, The Journal of Biological Chemistry.

[5]  D. Hultmark,et al.  HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  R. Schoenheimer,et al.  Synthesis and destruction of cholesterol in the organism. , 1933 .

[7]  M. Brown,et al.  A receptor-mediated pathway for cholesterol homeostasis. , 1986, Science.

[8]  F. Wieland,et al.  VIP21/caveolin is a cholesterol-binding protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Tjian,et al.  SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. , 1996, Genes & development.

[10]  D. Selkoe,et al.  Amyloid β-Protein and the Genetics of Alzheimer's Disease* , 1996, The Journal of Biological Chemistry.

[11]  R. D. Simoni,et al.  Molecular Dissection of the Role of the Membrane Domain in the Regulated Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (*) , 1995, The Journal of Biological Chemistry.

[12]  B. Spiegelman,et al.  ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. , 1996, Genes & development.

[13]  D. Baltimore,et al.  32 The Helix-Loop-Helix Motif: Structure and Function , 1992 .

[14]  Andrew Bohm,et al.  Crystal structure of a GA protein βγdimer at 2.1 Å resolution , 1996, Nature.

[15]  H. Hobbs,et al.  Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. , 1995, Genomics.

[16]  G. Shipley,et al.  Physical-chemical basis of lipid deposition in atherosclerosis. , 1974, Science.

[17]  M. Brown,et al.  Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. T. Hasan,et al.  Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression , 1994, Somatic cell and molecular genetics.

[19]  Weiming Xia,et al.  Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice , 1997, Nature Medicine.

[20]  I. Shechter,et al.  Molecular Cloning and Functional Analysis of the Promoter of the Human Squalene Synthase Gene (*) , 1995, The Journal of Biological Chemistry.

[21]  Raman Nambudripad,et al.  The ancient regulatory-protein family of WD-repeat proteins , 1994, Nature.

[22]  P. S. St George-Hyslop,et al.  Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins* , 1997, The Journal of Biological Chemistry.

[23]  B. Lamb Presenilins, amyloid-β and Alzheimer's disease , 1997, Nature Medicine.

[24]  X. Hua,et al.  Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein , 1996, Cell.

[25]  J. Dietschy,et al.  Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. , 1993, Annual review of nutrition.

[26]  M D Siperstein,et al.  Feedback control of mevalonate synthesis by dietary cholesterol. , 1966, The Journal of biological chemistry.

[27]  M. T. Hasan,et al.  Chinese hamster ovary cell mutants affecting cholesterol metabolism. , 1997, Current opinion in lipidology.

[28]  M. Brown,et al.  Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. , 1993, The Journal of biological chemistry.

[29]  M. T. Hasan,et al.  Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-depedent regulation of cholesterol metabolism , 1994, Somatic cell and molecular genetics.

[30]  T. Chang,et al.  Evidence for coordinate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase ad low density lipoprotein binding activity. , 1981, The Journal of biological chemistry.

[31]  R. Hammer,et al.  Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. , 1997, The Journal of clinical investigation.

[32]  ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. , 1993, Molecular and cellular biology.

[33]  R. Hammer,et al.  Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. , 1996, The Journal of clinical investigation.

[34]  P. Edwards,et al.  Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[35]  M. Evans,et al.  Loss of transcriptional activation of three sterol-regulated genes in mutant hamster cells , 1993, Molecular and cellular biology.

[36]  X. Hua,et al.  Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane (*) , 1996, The Journal of Biological Chemistry.

[37]  M. Brown,et al.  SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  P. Edwards,et al.  Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene* , 1996, The Journal of Biological Chemistry.

[39]  S. Sprang,et al.  The structure of the G protein heterotrimer Giα1 β 1 γ 2 , 1995, Cell.

[40]  J. Goldstein,et al.  Regulation of the mevalonate pathway , 1990, Nature.

[41]  X. Hua,et al.  Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection * , 1995, The Journal of Biological Chemistry.

[42]  A. Admon,et al.  SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene , 1993, Cell.

[43]  M. Brown,et al.  Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). , 1994, The Journal of biological chemistry.

[44]  P. Conrad,et al.  Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation , 1994, The Journal of cell biology.

[45]  T. Osborne,et al.  Transcriptional control mechanisms in the regulation of cholesterol balance. , 1995, Critical reviews in eukaryotic gene expression.

[46]  R. Simon,et al.  The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase. , 1992, The Journal of biological chemistry.

[47]  M. Brown,et al.  Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  R. Stroud,et al.  Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. , 1985, The Journal of biological chemistry.

[49]  M. Brown,et al.  Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[50]  N. Bucher,et al.  β-hydroxy-β-methylglutaryl coenzyme a reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver , 1960 .

[51]  P. Beachy,et al.  Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development , 1996, Science.

[52]  C. B. Taylor,et al.  Cholesterol metabolism. I. Effect of dietary cholesterol on the synthesis of cholesterol in dog tissue in vitro. , 1953, The Journal of biological chemistry.

[53]  B. Spiegelman,et al.  Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain , 1995, Molecular and cellular biology.

[54]  J. Goldstein,et al.  Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. , 1994, Genes & development.

[55]  J. Goldstein,et al.  Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2* , 1997, The Journal of Biological Chemistry.

[56]  A. Keys Coronary heart disease--the global picture. , 1975, Atherosclerosis.

[57]  T. Osborne,et al.  Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter* , 1996, The Journal of Biological Chemistry.

[58]  X. Hua,et al.  Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment , 1996, Cell.

[59]  X. Hua,et al.  SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis , 1994, Cell.

[60]  J. Rosenfeld,et al.  Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. , 1996, Proceedings of the National Academy of Sciences of the United States of America.