Nanoparticles in the environment: assessment using the causal diagram approach

Nanoparticles (NPs) cause concern for health and safety as their impact on the environment and humans is not known. Relatively few studies have investigated the toxicological and environmental effects of exposure to naturally occurring NPs (NNPs) and man-made or engineered NPs (ENPs) that are known to have a wide variety of effects once taken up into an organism.A review of recent knowledge (between 2000-2010) on NP sources, and their behaviour, exposure and effects on the environment and humans was performed. An integrated approach was used to comprise available scientific information within an interdisciplinary logical framework, to identify knowledge gaps and to describe environment and health linkages for NNPs and ENPs.The causal diagram has been developed as a method to handle the complexity of issues on NP safety, from their exposure to the effects on the environment and health. It gives an overview of available scientific information starting with common sources of NPs and their interactions with various environmental processes that may pose threats to both human health and the environment. Effects of NNPs on dust cloud formation and decrease in sunlight intensity were found to be important environmental changes with direct and indirect implication in various human health problems. NNPs and ENPs exposure and their accumulation in biological matrices such as microbiota, plants and humans may result in various adverse effects. The impact of some NPs on human health by ROS generation was found to be one of the major causes to develop various diseases.A proposed cause-effects diagram for NPs is designed considering both NNPs and ENPs. It represents a valuable information package and user-friendly tool for various stakeholders including students, researchers and policy makers, to better understand and communicate on issues related to NPs.

[1]  A. Gelencser,et al.  Atmospheric brown clouds: From local air pollution to climate change , 2010 .

[2]  David E Newby,et al.  Do inhaled carbon nanoparticles translocate directly into the circulation in humans? , 2006, American journal of respiratory and critical care medicine.

[3]  C. Vionnet.  [Environmental health]. , 1983, Krankenpflege. Soins infirmiers.

[4]  D. Griffin,et al.  Aerobiology and the global transport of desert dust. , 2006, Trends in ecology & evolution.

[5]  Anindita Sengupta,et al.  Aqueous toxicity and food chain transfer of quantum dots™ in freshwater algae and Ceriodaphnia dubia , 2008, Environmental toxicology and chemistry.

[6]  V. Castranova,et al.  Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells , 2008 .

[7]  Nanna B. Hartmann,et al.  Toxicity and bioaccumulation of xenobiotic organic compounds in the presence of aqueous suspensions of aggregates of nano-C(60). , 2008, Aquatic toxicology.

[8]  W. Burch,et al.  Passage of inhaled particles into the blood circulation in humans. , 2002, Circulation.

[9]  Jongheop Yi,et al.  Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics. , 2009, Environmental science & technology.

[10]  P. Krogh,et al.  The toxicity testing of double-walled nanotubes-contaminated food to Eisenia veneta earthworms. , 2008, Ecotoxicology and environmental safety.

[11]  Qian Hu,et al.  Uptake, translocation, and transmission of carbon nanomaterials in rice plants. , 2009, Small.

[12]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[13]  Maria Dusinska,et al.  Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation. , 2010, The Science of the total environment.

[14]  Teresa F. Fernandes,et al.  Interactions between carbon black nanoparticles and the brown algae Fucus serratus: Inhibition of fertilization and zygotic development , 2008 .

[15]  M. Morandi,et al.  Nanoparticle‐induced platelet aggregation and vascular thrombosis , 2005, British journal of pharmacology.

[16]  J. Kiehl,et al.  Atmospheric brown clouds: impacts on South Asian climate and hydrological cycle. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  P. S. Praveen,et al.  Brown Clouds over South Asia: Biomass or Fossil Fuel Combustion? , 2009, Science.

[18]  C. Tyler,et al.  Review: Do engineered nanoparticles pose a significant threat to the aquatic environment? , 2010, Critical reviews in toxicology.

[19]  M. Haase,et al.  In-vivo imaging of the uptake of upconversion nanoparticles by plant roots. , 2009, Journal of biomedical nanotechnology.

[20]  I. Zuhorn,et al.  Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. , 2004, The Biochemical journal.

[21]  Ling Yang,et al.  Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles. , 2005, Toxicology letters.

[22]  Christopher M Long,et al.  Diesel exhaust particulate (DEP) and nanoparticle exposures: What do DEP human clinical studies tell us about potential human health hazards of nanoparticles? , 2010, Inhalation toxicology.

[23]  Xuezhi Zhang,et al.  Trophic transfer of TiO(2) nanoparticles from Daphnia to zebrafish in a simplified freshwater food chain. , 2010, Chemosphere.

[24]  Hans Bouwmeester,et al.  Review of health safety aspects of nanotechnologies in food production. , 2009, Regulatory toxicology and pharmacology : RTP.

[25]  Eva Oberdörster,et al.  Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow. , 2006, Marine environmental research.

[26]  Alena Bartonova,et al.  Policy relevant results from an expert elicitation on the health risks of phthalates , 2012, Environmental Health.

[27]  C. Instanes,et al.  Toxicity of Silver Nanomaterials in Higher Eukaryotes , 2011 .

[28]  Qamar Rahman,et al.  Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. , 2002, Environmental health perspectives.

[29]  Alena Bartonova,et al.  We’re only in it for the knowledge? A problem solving turn in environment and health expert elicitation , 2012, Environmental Health.

[30]  K. Linge,et al.  Bioavailability of nanoscale metal oxides TiO(2), CeO(2), and ZnO to fish. , 2010, Environmental science & technology.

[31]  Jamie R Lead,et al.  Nanomaterials in the environment: Behavior, fate, bioavailability, and effects , 2008, Environmental toxicology and chemistry.

[32]  M. Jaurand,et al.  Particle and Fibre Toxicology Mesothelioma: Do Asbestos and Carbon Nanotubes Pose the Same Health Risk? , 2022 .

[33]  Massimo Bovenzi,et al.  Nanoparticle dermal absorption and toxicity: a review of the literature , 2009, International archives of occupational and environmental health.

[34]  Lenore L. Dai,et al.  Effects of functionalized and nonfunctionalized single‐walled carbon nanotubes on root elongation of select crop species , 2008, Environmental toxicology and chemistry.

[35]  David Brown,et al.  The pulmonary toxicology of ultrafine particles. , 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[36]  J. Morrow,et al.  Trophic transfer of nanoparticles in a simplified invertebrate food web. , 2008, Nature nanotechnology.

[37]  S. Wilsona,et al.  Changes in tropospheric composition and air quality due to stratospheric ozone depletion and climate change , 2009 .

[38]  Craig A. Poland,et al.  Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. , 2008, Nature nanotechnology.

[39]  Thomas Kuhlbusch,et al.  Particle and Fibre Toxicology BioMed Central Review The potential risks of nanomaterials: a review carried out for ECETOC , 2006 .

[40]  Baoshan Xing,et al.  Root uptake and phytotoxicity of ZnO nanoparticles. , 2008, Environmental science & technology.

[41]  Kevin Robbie,et al.  Nanomaterials and nanoparticles: Sources and toxicity , 2007, Biointerphases.

[42]  S. Hirano,et al.  Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes , 2009, Archives of Toxicology.

[43]  Kevin C Jones,et al.  Novel method for the direct visualization of in vivo nanomaterials and chemical interactions in plants. , 2009, Environmental science & technology.

[44]  M R Wiesner,et al.  Comparison of manufactured and black carbon nanoparticle concentrations in aquatic sediments. , 2009, Environmental pollution.

[45]  M. Kulmala,et al.  On the formation and growth of atmospheric nanoparticles , 2008 .

[46]  Myrtill Simkó,et al.  Risks from accidental exposures to engineered nanoparticles and neurological health effects: A critical review , 2010, Particle and Fibre Toxicology.

[47]  N. Qafoku.  Chapter Two - Terrestrial Nanoparticles and Their Controls on Soil-/Geo-Processes and Reactions , 2010 .

[48]  Linsey C Marr,et al.  Environmental and Human Health Risks of Aerosolized Silver Nanoparticles , 2010, Journal of the Air & Waste Management Association.

[49]  D. Sparks,et al.  Nanominerals, Mineral Nanoparticles, and Earth Systems , 2008, Science.

[50]  D. M. Cunnold,et al.  Evidence for Substantial Variations of Atmospheric Hydroxyl Radicals in the Past Two Decades , 2001, Science.

[51]  Kerstin Hund-Rinke,et al.  Ecotoxic Effect of Photocatalytic Active Nanoparticles (TiO2) on Algae and Daphnids (8 pp) , 2006, Environmental science and pollution research international.

[52]  M. Manning,et al.  Short-term variations in the oxidizing power of the atmosphere , 2005, Nature.

[53]  M. Oliva,et al.  Responses of restinga plant species to pollution from an iron pelletization factory , 2006 .

[54]  T. Xia,et al.  Potential health impact of nanoparticles. , 2009, Annual review of public health.

[55]  M. Nasterlack,et al.  Considerations on occupational medical surveillance in employees handling nanoparticles , 2008, International archives of occupational and environmental health.

[56]  Martin Wild,et al.  Atmospheric brown clouds: impacts on South Asian climate and hydrological cycle. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Diego Rubiales,et al.  Absorption and translocation to the aerial part of magnetic carbon-coated nanoparticles through the root of different crop plants , 2010, Journal of nanobiotechnology.

[58]  Dong-Hwang Chen,et al.  Synthesis of water-soluble blue photoluminescent silicon nanocrystals with oxide surface passivation. , 2009, Small.

[59]  Richard D Handy,et al.  Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis , 2008, Ecotoxicology.

[60]  Tae-Jong Yoon,et al.  Toxicity and tissue distribution of magnetic nanoparticles in mice. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[61]  T. Naganuma,et al.  Detailed identification of desert-originated bacteria carried by Asian dust storms to Japan , 2007 .

[62]  Khara D Grieger,et al.  Setting the limits for engineered nanoparticles in European surface waters - are current approaches appropriate? , 2009, Journal of environmental monitoring : JEM.

[63]  G. Oberdörster,et al.  Translocation and effects of ultrafine particles outside of the lung. , 2006, Clinics in occupational and environmental medicine.

[64]  Jürgen Pauluhn,et al.  Comparative pulmonary response to inhaled nanostructures: considerations on test design and endpoints , 2009, Inhalation toxicology.

[65]  M. G. Morgan,et al.  Elicitation of Expert Judgments of Aerosol Forcing , 2006 .

[66]  Amy K Madl,et al.  Health effects of inhaled engineered and incidental nanoparticles , 2009, Critical reviews in toxicology.

[67]  Nanna B. Hartmann,et al.  Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing , 2008, Ecotoxicology.

[68]  Paul R. Lockman,et al.  Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability , 2004, Journal of drug targeting.

[69]  D. Griffin,et al.  Atmospheric Movement of Microorganisms in Clouds of Desert Dust and Implications for Human Health , 2007, Clinical Microbiology Reviews.

[70]  W. Kreyling,et al.  Translocation of Inhaled Ultrafine Particles to the Brain , 2004, Inhalation toxicology.

[71]  Maria C Powell,et al.  Nanomaterial health effects--part 1: background and current knowledge. , 2006, WMJ : official publication of the State Medical Society of Wisconsin.

[72]  Val Vallyathan,et al.  Single- and Multi-Wall Carbon Nanotubes Versus Asbestos: Are the Carbon Nanotubes a New Health Risk to Humans? , 2010, Journal of toxicology and environmental health. Part A.

[73]  R D Tyagi,et al.  Engineered nanoparticles in wastewater and wastewater sludge--evidence and impacts. , 2010, Waste management.

[74]  Franz Rohrer,et al.  Strong correlation between levels of tropospheric hydroxyl radicals and solar ultraviolet radiation , 2006, Nature.

[75]  Nanna B. Hartmann,et al.  Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi , 2008, Ecotoxicology.

[76]  Flemming R Cassee,et al.  Exposure, Health and Ecological Effects Review of Engineered Nanoscale Cerium and Cerium Oxide Associated with its Use as a Fuel Additive , 2011, Critical reviews in toxicology.

[77]  E. Antignac,et al.  Safety assessment of personal care products/cosmetics and their ingredients. , 2010, Toxicology and applied pharmacology.

[78]  Karluss Thomas,et al.  Moving toward exposure and risk evaluation of nanomaterials: challenges and future directions. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[79]  Mark R Wiesner,et al.  Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. , 2006, Nano letters.

[80]  J. Kanno,et al.  Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. , 2008, The Journal of toxicological sciences.

[81]  Run-Lie Shia,et al.  Potential Environmental Impact of a Hydrogen Economy on the Stratosphere , 2003, Science.