Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry.

[1]  W S Hancock,et al.  Analysis of Oligonucleotides by HPLC-Electrospray Ionization Mass Spectrometry. , 1997, Analytical chemistry.

[2]  L. Cummins,et al.  On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites. , 1997, Analytical chemistry.

[3]  Martin Gilar,et al.  Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides: retention prediction. , 2002, Journal of chromatography. A.

[4]  G. Dai,et al.  Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides. , 2007, Journal of pharmaceutical and biomedical analysis.

[5]  R. Yu,et al.  Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100 , 2007, Drug Metabolism and Disposition.

[6]  W. Guo,et al.  Quantification of raf antisense oligonucleotide (rafAON) in biological matrices by LC-MS/MS to support pharmacokinetics of a liposome-entrapped rafAON formulation. , 2005, Biomedical chromatography : BMC.

[7]  G. Marcucci,et al.  Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry , 2008, The AAPS Journal.

[8]  S. Ito,et al.  Enhanced mass detection of oligonucleotides using reverse-phase high-performance liquid chromatography/electrospray ionization ion-trap mass spectrometry. , 2002, Rapid communications in mass spectrometry : RCM.

[9]  J. Gebler,et al.  Characterization of therapeutic oligonucleotides using liquid chromatography with on-line mass spectrometry detection. , 2003, Oligonucleotides.

[10]  Jennifer A. Lockridge,et al.  Liquid chromatography electrospray ionization mass spectrometry analysis of the ocular metabolites from a short interfering RNA duplex. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  H. Karnes,et al.  Precision, Accuracy, and Data Acceptance Criteria in Biopharmaceutical Analysis , 1993, Pharmaceutical Research.

[12]  I. Ahmad,et al.  Mass spectrometry and enzyme-linked immunosorbent assay methods for the quantitation of liposomal antisense oligonucleotide (LE-rafAON) in human plasma. , 2004, Methods in enzymology.

[13]  R. Yu,et al.  Development of an Ion-Pair Reverse-Phase Liquid Chromatographic/Tandem Mass Spectrometry Method for the Determination of an 18-Mer Phosphorothioate Oligonucleotide in Mouse Liver Tissue , 2005, European journal of mass spectrometry.

[14]  A. Levin,et al.  Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma. , 2002, Analytical biochemistry.

[15]  G. Marcucci,et al.  Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[16]  J. Hochman,et al.  Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[17]  S. Pitsch,et al.  Analysis of biological and synthetic ribonucleic acids by liquid chromatography-mass spectrometry using monolithic capillary columns. , 2005, Analytical chemistry.

[18]  Jian Lin,et al.  Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spectrometry. , 2007, Analytical chemistry.

[19]  C. Huber,et al.  Analysis of nucleic acids by on-line liquid chromatography-mass spectrometry. , 2001, Mass spectrometry reviews.

[20]  R. Griffey,et al.  Utility of organic bases for improved electrospray mass spectrometry of oligonucleotides. , 1995, Rapid communications in mass spectrometry : RCM.

[21]  A. Levin,et al.  Application of novel quantitative bioanalytical methods for pharmacokinetic and pharmacokinetic/pharmacodynamic assessments of antisense oligonucleotides. , 2004, Current opinion in drug discovery & development.