Affinity-Based Analysis Methods for the Detection of Aminoglycoside Antibiotic Residues in Animal-Derived Foods: A Review

With the increasingly serious problem of aminoglycoside antibiotic residues, it is imperative to develop rapid, sensitive and efficient detection methods. This article reviews the detection methods of aminoglycoside antibiotics in animal-derived foods, including enzyme-linked immunosorbent assay, fluorescent immunoassay, chemical immunoassay, affinity sensing assay, lateral flow immunochromatography and molecular imprinted immunoassay. After evaluating the performance of these methods, the advantages and disadvantages were analyzed and compared. Furthermore, development prospects and research trends were proposed and summarized. This review can serve as a basis for further research and provide helpful references and new insights for the analysis of aminoglycoside residues. Accordingly, the in-depth investigation and analysis will certainly make great contributions to food safety, public hygiene and human health.

[1]  Bin Chen,et al.  Gold nanoparticle‐carbon nanotube nanohybrids with peroxidase‐like activity for the highly‐sensitive immunoassay of kanamycin in milk , 2022, International Journal of Food Science & Technology.

[2]  Wenchuan Guo,et al.  Electrochemical detection of aminoglycoside antibiotics residuals in milk based on magnetic molecularly imprinted particles and metal ions. , 2022, Food chemistry.

[3]  Jiayi Chen,et al.  An enhanced immunochromatography assay based on colloidal gold-decorated polydopamine for rapid and sensitive determination of gentamicin in animal-derived food. , 2022, Food chemistry.

[4]  C. Yu,et al.  Reduced Graphene Oxide/Poly(2-Aminopyridine) Modified Molecularly Imprinted Glassy Carbon Electrode (GCE) for the Determination of Kanamycin in Milk and Pork by Differential Pulse Voltammetry (DPV) , 2022, Analytical Letters.

[5]  Yuyin Zhang,et al.  Chemiluminescence microarray immunoassay for multiple aminoglycoside antibiotics based on carbon nanotube–assisted signal amplification , 2021, Analytical and Bioanalytical Chemistry.

[6]  P. Luo,et al.  A highly sensitive and quantitative time resolved fluorescent microspheres lateral flow immunoassay for streptomycin and dihydrostreptomycin in milk, honey, muscle, liver, and kidney , 2021, Analytica Chimica Acta.

[7]  Xue-song Feng,et al.  Aminoglycosides in Food: Recent Updates on the Pretreatment and Analysis Methods , 2021, Food Reviews International.

[8]  P. Luo,et al.  Ultratrace Analysis of Neomycin Residues in Milk at Femtogram Levels by Flow-Through Immunoaffinity Chromatography Test , 2021, Food Analytical Methods.

[9]  Song Hu,et al.  Developmental trend of immunoassays for monitoring hazards in food samples: A review , 2021 .

[10]  Xiaonan Lu,et al.  Molecular imprinting technology for sensing foodborne pathogenic bacteria , 2021, Analytical and Bioanalytical Chemistry.

[11]  Xingbo Shi,et al.  Recent improvements in enzyme-linked immunosorbent assays based on nanomaterials. , 2021, Talanta.

[12]  Boris B. Dzantiev,et al.  Perspective and application of molecular imprinting approach for antibiotic detection in food and environmental samples: A critical review , 2020 .

[13]  Cheng Li,et al.  Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics , 2020, Antibiotics.

[14]  Yanwei Ji,et al.  Recent Advances in Optical Detection of Aminoglycosides , 2020, Applied Sciences.

[15]  K. Allison,et al.  Potentiating aminoglycoside antibiotics to reduce their toxic side effects , 2020, PloS one.

[16]  Bin Chen,et al.  Using bimetallic Au@Pt nanozymes as a visual tag and as an enzyme mimic in enhanced sensitive lateral-flow immunoassays: Application for the detection of streptomycin. , 2020, Analytica chimica acta.

[17]  X. Bing,et al.  Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs , 2020, Molecules.

[18]  Haiyang Jiang,et al.  Highly sensitive chromatographic time-resolved fluoroimmunoassay for rapid onsite detection of streptomycin in milk. , 2020, Journal of dairy science.

[19]  Yaping Tian,et al.  Multi-cycle signal-amplified colorimetric detection of tobramycin based on dual-strand displacement and three-way DNA junction , 2020 .

[20]  A. Zherdev,et al.  Sensitive lateral flow immunoassay of an antibiotic neomycin in foodstuffs , 2020, Journal of Food Science and Technology.

[21]  Heather K. Allen,et al.  Toward Antibiotic Stewardship: Route of Antibiotic Administration Impacts the Microbiota and Resistance Gene Diversity in Swine Feces , 2020, Frontiers in Veterinary Science.

[22]  N. Bagheri,et al.  Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review , 2020, Expert opinion on drug safety.

[23]  S. Sukhishvili,et al.  Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry , 2020, Journal of Analytical Science and Technology.

[24]  P. Corvini,et al.  Biodegradation of antibiotics: the new resistance determinants - part I. , 2020, New biotechnology.

[25]  Yongzhong Qian,et al.  Poly(N-acryloyl-glucosamine-co-methylenebisacrylamide)-based hydrophilic magnetic nanoparticles for the extraction of aminoglycosides in meat samples. , 2020, Journal of chromatography. A.

[26]  Xiaoyi Lou,et al.  Simultaneous determination of ten aminoglycoside antibiotics in aquatic feeds by high-performance liquid chromatography quadrupole-orbitrap mass spectrometry with pass-through cleanup. , 2019, Chirality.

[27]  Y. Liu,et al.  Highly sensitive determination of aminoglycoside residues in food by sheathless CE-ESI-MS/MS , 2019, Analytical Methods.

[28]  Andres F Zuluaga,et al.  [Effectiveness of the antibiotic combinations for enterococcal infections treatment: a critical review]. , 2019, Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia.

[29]  Jichao Liu,et al.  Recent progress in the construction of nanozyme-based biosensors and their applications to food safety assay , 2019, TrAC Trends in Analytical Chemistry.

[30]  Y. Fujii,et al.  Simultaneous Determination of Aminoglycoside Residues in Livestock and Fishery Products by Phenylboronic Acid Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry , 2019, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[31]  Jonathan C. Cho,et al.  Aminoglycoside Allergic Reactions , 2019, Pharmacy.

[32]  Hualin Yang,et al.  Determination of Kanamycin by High Performance Liquid Chromatography , 2019, Molecules.

[33]  J. Kochana,et al.  Electrochemical Immunosensors for Antibiotic Detection , 2019, Biosensors.

[34]  Minghua Wang,et al.  Covalent organic framework-based electrochemical aptasensors for the ultrasensitive detection of antibiotics. , 2019, Biosensors & bioelectronics.

[35]  Suryasnata Tripathy,et al.  Label free, electrochemical detection of atrazine using electrospun Mn2O3 nanofibers: Towards ultrasensitive small molecule detection , 2019, Sensors and Actuators B: Chemical.

[36]  U. Holzgrabe,et al.  Quantitative structure-property relationship modeling of polar analytes lacking UV chromophores to charged aerosol detector response , 2019, Analytical and Bioanalytical Chemistry.

[37]  R. Lai,et al.  Electrochemical aptamer-based sensors for food and water analysis: A review. , 2019, Analytica chimica acta.

[38]  Zhenli Liu,et al.  A Novel Microbiological Method in Microtiter Plates for Screening Seven Kinds of Widely Used Antibiotics Residues in Milk, Chicken Egg and Honey , 2019, Front. Microbiol..

[39]  Hongtao Lei,et al.  Ultrasensitive immunosensor for acrylamide based on chitosan/SnO2-SiC hollow sphere nanochains/gold nanomaterial as signal amplification. , 2019, Analytica chimica acta.

[40]  Hui Dong,et al.  Label-free immunosensors based on a novel multi-amplification signal strategy of TiO2-NGO/Au@Pd hetero-nanostructures. , 2019, Biosensors & bioelectronics.

[41]  S. Singh,et al.  Label free electrochemical detection of cardiac biomarker troponin T using ZnSnO3 perovskite nanomaterials , 2019, Analytical Methods.

[42]  Hunjoo Lee,et al.  Web-based Korean maximum residue limit evaluation tools: an applied example of maximum residue limit evaluation for trichlorfon in fishery products , 2019, Environmental Science and Pollution Research.

[43]  Yun-hui Dong,et al.  Sandwich-type electrochemical immunosensor for sensitive detection of CEA based on the enhanced effects of Ag NPs@CS spaced Hemin/rGO. , 2019, Biosensors & bioelectronics.

[44]  H. Alrabiah,et al.  Automated flow fluorescent noncompetitive immunoassay for measurement of human plasma levels of monoclonal antibodies used for immunotherapy of cancers with KinExA™ 3200 biosensor. , 2019, Talanta.

[45]  Kun Zeng,et al.  Chemiluminescence imaging immunoassay for multiple aminoglycoside antibiotics in cow milk , 2019, International Journal of Food Science & Technology.

[46]  Kun Zeng,et al.  Visual dual dot immunoassay for the simultaneous detection of kanamycin and streptomycin in milk , 2019, Analytical Methods.

[47]  A. Gajda,et al.  Multi-residues UHPLC-MS/MS analysis of 53 antibacterial compounds in poultry feathers as an analytical tool in food safety assurance. , 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[48]  Wenbing Shi,et al.  A signal-on electrochemical aptasensor for highly sensitive and specific detection of kanamycin based on target-induced signaling probe shifting mechanism , 2018, Sensors and Actuators B: Chemical.

[49]  R. Galarini,et al.  Simultaneous determination of aminoglycosides and colistins in food. , 2018, Food chemistry.

[50]  Jie Zhou,et al.  Determination of kanamycin using a molecularly imprinted SPR sensor. , 2018, Food chemistry.

[51]  Gungun Lin,et al.  Quantitative Lateral Flow Strip Sensor Using Highly Doped Upconversion Nanoparticles. , 2018, Analytical chemistry.

[52]  Qi Kang,et al.  A smartphone-based ratiometric resonance light scattering device for field analysis of Pb2+ in river water samples and immunoassay of alpha fetoprotein using PbS nanoparticles as signal tag , 2018, Sensors and Actuators B: Chemical.

[53]  Yiqiang Chen,et al.  Quadruplex gold immunochromatogaraphic assay for four families of antibiotic residues in milk. , 2018, Food chemistry.

[54]  V. Bartkevičs,et al.  Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed-mode liquid chromatography with quadrupole time-of-flight mass spectroscopy with heated electrospray ionization. , 2018, Journal of separation science.

[55]  M. Marco,et al.  Immunoassay and amperometric biosensor approaches for the detection of deltamethrin in seawater , 2018, Analytical and Bioanalytical Chemistry.

[56]  Nan-Fu Chiu,et al.  Highly sensitive carboxyl-graphene oxide-based surface plasmon resonance immunosensor for the detection of lung cancer for cytokeratin 19 biomarker in human plasma , 2018, Sensors and Actuators B: Chemical.

[57]  Yvonne Joseph,et al.  Aptamer-Based Biosensors for Antibiotic Detection: A Review , 2018, Biosensors.

[58]  Daichi Asakawa,et al.  Sensitivity enhancement of aminoglycosides in hydrophilic interaction liquid chromatography with tandem mass spectrometry by post-column addition of trace sodium acetate in methanol , 2018, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[59]  L. Angnes,et al.  Electrochemical immunosensors - A powerful tool for analytical applications. , 2018, Biosensors & bioelectronics.

[60]  Yi Li,et al.  Optimization and application of parallel solid-phase extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry for the determination of 11 aminoglycoside residues in honey and royal jelly. , 2018, Journal of chromatography. A.

[61]  P. Mottier,et al.  Determination of 14 aminoglycosides by LC-MS/MS using molecularly imprinted polymer solid phase extraction for clean-up , 2018, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[62]  D. Du,et al.  An Enhanced Direct Competitive Immunoassay for the Detection of Kanamycin and Tobramycin in Milk Using Multienzyme-Particle Amplification , 2018, Food Analytical Methods.

[63]  C. Deng,et al.  Synthesis of magnetic graphene/mesoporous silica composites with boronic acid-functionalized pore-walls for selective and efficient residue analysis of aminoglycosides in milk. , 2018, Food chemistry.

[64]  Yan Gao Antibody Development and Immunoassays for Polycyclic Aromatic Hydrocarbons (PAHs) , 2018 .

[65]  Chengjun Sun,et al.  Simultaneous Determination of 11 Aminoglycoside Residues in Honey, Milk, and Pork by Liquid Chromatography with Tandem Mass Spectrometry and Molecularly Imprinted Polymer Solid Phase Extraction. , 2017, Journal of AOAC International.

[66]  Lei Chen,et al.  Development of multiple monolithic fiber solid-phase microextraction and liquid chromatography-tandem mass spectrometry method for the sensitive monitoring of aminoglycosides in honey and milk samples. , 2017, Journal of separation science.

[67]  Haiyang Jiang,et al.  Multiplex Lateral Flow Immunoassays Based on Amorphous Carbon Nanoparticles for Detecting Three Fusarium Mycotoxins in Maize. , 2017, Journal of agricultural and food chemistry.

[68]  Junping Wang,et al.  Development and Validation of a Reproducible and Label-Free Surface Plasmon Resonance Immunosensor for Enrofloxacin Detection in Animal-Derived Foods , 2017, Sensors.

[69]  S. Eremin,et al.  Detection of kanamycin and gentamicin residues in animal-derived food using IgY antibody based ic-ELISA and FPIA. , 2017, Food chemistry.

[70]  V. Gaudin,et al.  Strategies for the screening of antibiotic residues in eggs: comparison of the validation of the classical microbiological method with an immunobiosensor method , 2017, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[71]  J. Marty,et al.  Disposable and portable aptamer functionalized impedimetric sensor for detection of kanamycin residue in milk sample , 2017 .

[72]  S. Piletsky,et al.  A pseudo-ELISA based on molecularly imprinted nanoparticles for detection of gentamicin in real samples , 2017 .

[73]  Valérie Gaudin,et al.  Advances in biosensor development for the screening of antibiotic residues in food products of animal origin - A comprehensive review. , 2017, Biosensors & bioelectronics.

[74]  Liqiang Liu,et al.  Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs , 2017 .

[75]  E. Verdon,et al.  Development and validation of a multiclass method for the determination of antibiotic residues in honey using liquid chromatography-tandem mass spectrometry , 2017, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[76]  Xiaoqi Tao,et al.  Dual-Label Chemiluminescence Strategy for Multiplexed Immunoassay of 20 Fluoroquinolones, 15 β-Lactams, 15 Sulfonamides, and CAP in Milk , 2017, Food Analytical Methods.

[77]  Zheng-Jun Xie,et al.  Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of vancomycin in raw milk and animal feed , 2017 .

[78]  Qiqing Zhang,et al.  Urea-formaldehyde monolithic column for hydrophilic in-tube solid-phase microextraction of aminoglycosides. , 2017, Journal of chromatography. A.

[79]  X. Xia,et al.  A New Method Based on Time-Resolved Fluoroimmunoassay for the Detection of Streptomycin in Milk , 2017, Food Analytical Methods.

[80]  Liqiang Liu,et al.  Development of a specific monoclonal antibody assay and a rapid testing strip for the detection of apramycin residues in food samples , 2017 .

[81]  S. Lehotay,et al.  Simultaneous analysis of aminoglycosides with many other classes of drug residues in bovine tissues by ultrahigh-performance liquid chromatography–tandem mass spectrometry using an ion-pairing reagent added to final extracts , 2017, Analytical and Bioanalytical Chemistry.

[82]  Yaping Tian,et al.  An aptamer and functionalized nanoparticle-based strip biosensor for on-site detection of kanamycin in food samples. , 2017, The Analyst.

[83]  Lian Wang,et al.  Novel Two-Dimensional Liquid Chromatography–Tandem Mass Spectrometry for the Analysis of Twenty Antibiotics Residues in Dairy Products , 2017, Food Analytical Methods.

[84]  A. Pirogov,et al.  HPLC determination of tetracycline antibiotics in milk with post-column derivatization and fluorescence detection , 2016, Inorganic Materials.

[85]  Wenjuan Guo,et al.  A regular “signal attenuation” electrochemical aptasensor for highly sensitive detection of streptomycin , 2016 .

[86]  D. Du,et al.  Use of Carbon Nanotubes as a Solid Support To Establish Quantitative (Centrifugation) and Qualitative (Filtration) Immunoassays To Detect Gentamicin Contamination in Commercial Milk. , 2016, Journal of agricultural and food chemistry.

[87]  A. Molina,et al.  Control and prevention of antibiotic residues and contaminants in sheep and goat’s milk , 2016 .

[88]  Liqiang Liu,et al.  Development of an immunochromatographic strip assay for ractopamine detection using an ultrasensitive monoclonal antibody , 2016 .

[89]  T. Pizzolato,et al.  Determination of aminoglycoside residues in milk and muscle based on a simple and fast extraction procedure followed by liquid chromatography coupled to tandem mass spectrometry and time of flight mass spectrometry. , 2016, Talanta.

[90]  M. Tekin,et al.  Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations , 2016 .

[91]  Marilena E. Dasenaki,et al.  Analysis of 76 veterinary pharmaceuticals from 13 classes including aminoglycosides in bovine muscle by hydrophilic interaction liquid chromatography-tandem mass spectrometry. , 2016, Journal of chromatography. A.

[92]  J. Kauffmann,et al.  Antibodies as target for affinity biosensors , 2016 .

[93]  Mamas I. Prodromidis,et al.  Electrochemical immunosensors: Critical survey of different architectures and transduction strategies , 2016 .

[94]  P. Luo,et al.  Rapid and Sensitive Chemiluminescent Enzyme Immunoassay for the Determination of Neomycin Residues in Milk. , 2016, Biomedical and environmental sciences : BES.

[95]  Hongtao Lei,et al.  Broad-Specificity Chemiluminescence Enzyme Immunoassay for (Fluoro)quinolones: Hapten Design and Molecular Modeling Study of Antibody Recognition. , 2016, Analytical chemistry.

[96]  Wei Zhang,et al.  Novel fabrication of immunochromatographic assay based on up conversion phosphors for sensitive detection of clenbuterol. , 2016, Biosensors & bioelectronics.

[97]  T. Piech,et al.  Thin-layer chromatography—direct bioautography as an alternative method for screening of antibiotic residues in milk: A comparative study , 2016 .

[98]  S. Eremin,et al.  Sensitive immunochemical approaches for quantitative (FPIA) and qualitative (lateral flow tests) determination of gentamicin in milk. , 2016, Talanta.

[99]  Peng Zhai,et al.  Analysis of Pirlimycin Residues in Beef Muscle, Milk, and Honey by a Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay. , 2016, Journal of agricultural and food chemistry.

[100]  E. Du,et al.  Development of indirect competitive ELISA using egg yolk-derived immunoglobulin (IgY) for the detection of Gentamicin residues , 2016, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

[101]  Guobao Xu,et al.  A kanamycin sensor based on an electrosynthesized molecularly imprinted poly-o-phenylenediamine film on a single-walled carbon nanohorn modified glassy carbon electrode. , 2016, The Analyst.

[102]  Y. Wang,et al.  Preparation of Artificial Antigen and Development of IgY-Based Indirect Competitive ELISA for the Detection of Kanamycin Residues , 2016, Food Analytical Methods.

[103]  P. Halami,et al.  Emerging resistance to aminoglycosides in lactic acid bacteria of food origin—an impending menace , 2016, Applied Microbiology and Biotechnology.

[104]  Yang Song,et al.  Multi-color quantum dot-based fluorescence immunoassay array for simultaneous visual detection of multiple antibiotic residues in milk. , 2015, Biosensors & bioelectronics.

[105]  Liguang Xu,et al.  A gold immunochromatographic assay for the rapid and simultaneous detection of fifteen β-lactams. , 2015, Nanoscale.

[106]  Xiaqing Li,et al.  Colorimetric detection of kanamycin based on analyte-protected silver nanoparticles and aptamer-selective sensing mechanism. , 2015, Analytica chimica acta.

[107]  Wenjuan Guo,et al.  A novel electrochemical aptasensor based on MWCNTs–BMIMPF6 and amino functionalized graphene nanocomposite films for determination of kanamycin , 2015 .

[108]  Sunil Bhand,et al.  Ultrasensitive detection of streptomycin using flow injection analysis-electrochemical quartz crystal nanobalance (FIA-EQCN) biosensor. , 2015, Biosensors & bioelectronics.

[109]  Zhouping Wang,et al.  Aptamer-based fluorescence biosensor for chloramphenicol determination using upconversion nanoparticles , 2015 .

[110]  A. Berlina,et al.  'Traffic light' immunochromatographic test based on multicolor quantum dots for the simultaneous detection of several antibiotics in milk. , 2015, Biosensors & bioelectronics.

[111]  Songcheng Yu,et al.  Determination of residual enrofloxacin in food samples by a sensitive method of chemiluminescence enzyme immunoassay. , 2014, Food chemistry.

[112]  A. Denizli,et al.  Development of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods. , 2014, Talanta.

[113]  Xia Sun,et al.  Aptasensor based on the synergistic contributions of chitosan-gold nanoparticles, graphene-gold nanoparticles and multi-walled carbon nanotubes-cobalt phthalocyanine nanocomposites for kanamycin detection. , 2014, The Analyst.

[114]  L. Uzun,et al.  Molecular imprinted polypyrrole modified glassy carbon electrode for the determination of tobramycin , 2013 .

[115]  Frantisek Svec,et al.  Molecular imprinting of proteins in polymers attached to the surface of nanomaterials for selective recognition of biomacromolecules. , 2013, Biotechnology advances.

[116]  Xinmiao Liang,et al.  Synthesis of molecularly imprinted polymer sorbents and application for the determination of aminoglycosides antibiotics in honey. , 2013, Journal of chromatography. A.

[117]  Chunhai Fan,et al.  Development of electrochemical immunosensors towards point of care diagnostics. , 2013, Biosensors & bioelectronics.

[118]  Shuo Wang,et al.  Determination of streptomycin residues in animal-derived foods by a reliable and accurate enzyme-linked immunosorbent assay , 2013 .

[119]  Sha Zhang,et al.  Detection of aflatoxin M1 in milk by dynamic light scattering coupled with superparamagnetic beads and gold nanoprobes. , 2013, Journal of agricultural and food chemistry.

[120]  Huanghao Yang,et al.  Au(III)-promoted magnetic molecularly imprinted polymer nanospheres for electrochemical determination of streptomycin residues in food. , 2013, Biosensors & bioelectronics.

[121]  V. Belakhov,et al.  Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples. , 2013, Journal of pharmaceutical and biomedical analysis.

[122]  Hanqi Zhang,et al.  Ionic liquid-based microwave-assisted surfactant-improved dispersive liquid-liquid microextraction and derivatization of aminoglycosides in milk samples. , 2013, Journal of separation science.

[123]  Bingqian Liu,et al.  Molecular Imprint for Electrochemical Detection of Streptomycin Residues Using Enzyme Signal Amplification , 2013 .

[124]  M. Zou,et al.  Immunosensor based on magnetic relaxation switch and biotin-streptavidin system for the detection of Kanamycin in milk. , 2013, Biosensors & bioelectronics.

[125]  Junping Wang,et al.  Development of an enzyme-linked immunosorbent assay for the detection of gentamycin residues in animal-derived foods , 2013 .

[126]  Dna Sci-tech Development of dcELISA Method for Rapid Detection of Streptomycin Residue in Milk and Honey , 2013 .

[127]  Yiqiang Chen,et al.  Enzyme immunoassay and liquid chromatography-fluorescence detection for amikacin in raw milk. , 2012, Food chemistry.

[128]  F. Centrich,et al.  Determination of aminoglycoside residues in kidney and honey samples by hydrophilic interaction chromatography-tandem mass spectrometry. , 2012, Journal of separation science.

[129]  Bin Du,et al.  Ultrasensitive detection of kanamycin in animal derived foods by label-free electrochemical immunosensor. , 2012, Food chemistry.

[130]  Suxia Zhang,et al.  Development of a chemiluminescent competitive indirect ELISA method procedure for the determination of gentamicin in milk , 2012 .

[131]  Frank Davis,et al.  Recent trends in antibody based sensors. , 2012, Biosensors & bioelectronics.

[132]  Jun Ma,et al.  Synthesis and properties of bisphenol A molecular imprinted particle for selective recognition of BPA from water. , 2012, Journal of colloid and interface science.

[133]  A. Van Schepdael,et al.  Optimization of capillary electrophoresis method with contactless conductivity detection for the analysis of tobramycin and its related substances. , 2012, Journal of pharmaceutical and biomedical analysis.

[134]  Jie Wu,et al.  Chemiluminescent Immunoassay and its Applications , 2012 .

[135]  Xiwu Gao,et al.  Application of Suspension Array for Simultaneous Detection of Antibiotic Residues in Raw Milk , 2011 .

[136]  Katrin Reder-Christ,et al.  Biosensor Applications in the Field of Antibiotic Research—A Review of Recent Developments , 2011, Sensors.

[137]  S. Eremin,et al.  Pretreatment-free immunochromatographic assay for the detection of streptomycin and its application to the control of milk and dairy products. , 2011, Analytica chimica acta.

[138]  T. Zuchner,et al.  Lanthanide-based time-resolved luminescence immunoassays , 2011, Analytical and bioanalytical chemistry.

[139]  Liguang Xu,et al.  Development and application of one-step ELISA for the detection of neomycin in milk , 2011 .

[140]  A. Watson,et al.  Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis , 2010, Thorax.

[141]  G. Font,et al.  Determination of aminoglycoside and macrolide antibiotics in meat by pressurized liquid extraction and LC-ESI-MS. , 2010, Journal of separation science.

[142]  Itamar Willner,et al.  Surface plasmon resonance analysis of antibiotics using imprinted boronic acid-functionalized Au nanoparticle composites. , 2010, Analytical chemistry.

[143]  J. Bünzli Lanthanide luminescence for biomedical analyses and imaging. , 2010, Chemical reviews.

[144]  Xueping Zhou,et al.  Monoclonal antibody-based ELISA and colloidal gold-based immunochromatographic assay for streptomycin residue detection in milk and swine urine , 2010, Journal of Zhejiang University SCIENCE B.

[145]  W. Andersen,et al.  Analysis of aminoglycoside residues in bovine milk by liquid chromatography electrospray ion trap mass spectrometry after derivatization with phenyl isocyanate. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[146]  Noemí de-los-Santos-Álvarez,et al.  SPR sensing of small molecules with modified RNA aptamers: detection of neomycin B. , 2009, Biosensors & bioelectronics.

[147]  Xiangmei Li,et al.  Development of an enzyme-linked immunoassay for the detection of gentamicin in swine tissues , 2008 .

[148]  E. Turiel,et al.  Molecularly imprinted polymers for solid-phase extraction and solid-phase microextraction: recent developments and future trends. , 2007, Journal of chromatography. A.

[149]  E. Selimoğlu,et al.  Aminoglycoside-induced ototoxicity. , 2007, Current pharmaceutical design.

[150]  Chang-Hoon Han,et al.  Development of immunoassays for the detection of kanamycin in veterinary fields , 2006, Journal of veterinary science.

[151]  Chang-Hoon Han,et al.  Development of ELISA and immunochromatographic assay for the detection of neomycin. , 2006, Clinica chimica acta; international journal of clinical chemistry.

[152]  Chang-Hoon Han,et al.  Development of ELISA and immunochromatographic assay for the detection of gentamicin. , 2005, Journal of agricultural and food chemistry.

[153]  R. Abuknesha,et al.  Enzyme immunoassays for the analysis of streptomycin in milk, serum and water: development and assessment of a polyclonal antiserum and assay procedures using novel streptomycin derivatives. , 2005, The Analyst.

[154]  D. Chan,et al.  Immunosensors--principles and applications to clinical chemistry. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[155]  D. Stead Current methodologies for the analysis of aminoglycosides. , 2000, Journal of chromatography. B, Biomedical sciences and applications.

[156]  Richard Dietrich,et al.  Development of a One Step Strip Test for the Detection of (Dihydro)streptomycin Residues in Raw Milk , 2000 .

[157]  P. Tulkens,et al.  Aminoglycosides: Activity and Resistance , 1999, Antimicrobial Agents and Chemotherapy.

[158]  J. Fiekers Effects of the aminoglycoside antibiotics, streptomycin and neomycin, on neuromuscular transmission. I. Presynaptic considerations. , 1983, The Journal of pharmacology and experimental therapeutics.

[159]  K. Rybinska [Detection of streptomycin residues in milk]. , 1978, Roczniki Panstwowego Zakladu Higieny.