Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells
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[1] L. Cesaro,et al. Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells. , 2015, Biochimica et biophysica acta.
[2] D. Koh,et al. ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65 , 2015, Nucleic acids research.
[3] M. Specht,et al. Case records of the Massachusetts General Hospital. Case 1-2015. A 66-year-old woman with metastatic breast cancer after endocrine therapy. , 2015, The New England journal of medicine.
[4] J. Settleman,et al. Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells , 2014, Cancer & metabolism.
[5] Mingming Jia,et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer , 2014, Nucleic Acids Res..
[6] R. Clarke,et al. MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer , 2014, Molecular Cancer.
[7] R. Deberardinis,et al. Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels. , 2014, Cell metabolism.
[8] Takashi Suzuki,et al. Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma , 2014, The Journal of Steroid Biochemistry and Molecular Biology.
[9] Hongbing Zhang,et al. PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade*♦ , 2014, The Journal of Biological Chemistry.
[10] P. Puigserver,et al. Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression , 2014, Nature.
[11] E. Pasquale,et al. Association of the Breast Cancer Antiestrogen Resistance Protein 1 (BCAR1) and BCAR3 Scaffolding Proteins in Cell Signaling and Antiestrogen Resistance* , 2014, The Journal of Biological Chemistry.
[12] W. Zwart,et al. Tamoxifen resistance: from bench to bedside. , 2013, European journal of pharmacology.
[13] Amy R. Peck,et al. Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment , 2013, Breast Cancer Research.
[14] L. Fan,et al. Extended adjuvant endocrine therapy in hormone-receptor positive breast cancer. , 2013, Breast.
[15] Ja Hee Lee,et al. Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ , 2012, PloS one.
[16] D. Yee,et al. Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment. , 2012, Cancer research.
[17] A. Sivachenko,et al. Sequence analysis of mutations and translocations across breast cancer subtypes , 2012, Nature.
[18] S. Fuqua,et al. Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression , 2012, Breast Cancer Research.
[19] M. Higuchi,et al. The awakening of an advanced malignant cancer: an insult to the mitochondrial genome. , 2012, Biochimica et biophysica acta.
[20] K. Sahlin,et al. The effect of continuous and interval exercise on PGC‐1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle , 2012, Acta physiologica.
[21] Bin Zhang,et al. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse , 2011, Nucleic Acids Res..
[22] F. Sotgia,et al. Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells , 2011, Cancer biology & therapy.
[23] Hao Liu,et al. Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer , 2011, Journal of oncology.
[24] Andrew Skildum,et al. Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance , 2011, Breast Cancer Research and Treatment.
[25] M. Fernö,et al. A non-functional retinoblastoma tumor suppressor (RB) pathway in premenopausal breast cancer is associated with resistance to tamoxifen , 2011, Cell cycle.
[26] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[27] Yu Shyr,et al. A Gene Expression Signature from Human Breast Cancer Cells with Acquired Hormone Independence Identifies MYC as a Mediator of Antiestrogen Resistance , 2011, Clinical Cancer Research.
[28] A. Giordano,et al. Molecular Mechanism and Clinical Implications of Endocrine Therapy Resistance in Breast Cancer , 2010, Oncology.
[29] Jun Li,et al. Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity* , 2008, Journal of Biological Chemistry.
[30] S A Forbes,et al. The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.
[31] P. Argani,et al. Tamoxifen-stimulated growth of breast cancer due to p21 loss , 2008, Proceedings of the National Academy of Sciences.
[32] B. O’Malley,et al. Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] H. Varma,et al. Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells , 2007, PloS one.
[34] D. El-Ashry,et al. Reversal of the Estrogen Receptor–Negative Phenotype in Breast Cancer and Restoration of Antiestrogen Response , 2007, Clinical Cancer Research.
[35] Gordon B. Mills,et al. Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer , 2007 .
[36] Yvonne Will,et al. Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.
[37] Ke Ma,et al. Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression* , 2006, Journal of Biological Chemistry.
[38] Chenguang Wang,et al. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[39] T. Roche,et al. Ligand-induced Effects on Pyruvate Dehydrogenase Kinase Isoform 2* , 2006, Journal of Biological Chemistry.
[40] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[41] A. Sahin,et al. Tissue transglutaminase-induced alterations in extracellular matrix inhibit tumor invasion , 2005, Molecular Cancer.
[42] D. Chuang,et al. Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex , 2005, The EMBO journal.
[43] Y Wang,et al. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials , 2005, The Lancet.
[44] S. Conrad,et al. c-Myc Suppresses p21WAF1/CIP1 Expression during Estrogen Signaling and Antiestrogen Resistance in Human Breast Cancer Cells* , 2005, Journal of Biological Chemistry.
[45] C. Lange,et al. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. , 2005, Molecular endocrinology.
[46] R. Clarke,et al. The nuclear factor κB inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)–induced apoptosis in antiestrogen-resistant breast cancer cells , 2005, Molecular Cancer Therapeutics.
[47] R. Clarke,et al. Expression of an estrogen receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance. , 2004, Journal of molecular endocrinology.
[48] P. Neufer,et al. Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise , 2004, The Proceedings of the Nutrition Society.
[49] Robert A. Harris,et al. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. , 2004, Diabetes.
[50] A. Lykkesfeldt,et al. Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor Ialpha. , 2003, Endocrine-related cancer.
[51] D. Alessi,et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia , 2003, The EMBO journal.
[52] M. Buck,et al. Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal. , 2002, Physiological genomics.
[53] G. Kroemer,et al. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. , 2002, Biochimie.
[54] V. Giguère,et al. 4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ. , 2001, Endocrinology.
[55] F. Kern,et al. Hyperactivation of MAPK Induces Loss of ERα Expression in Breast Cancer Cells , 2001 .
[56] J. Lehmann,et al. 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[57] S. van der Flier,et al. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. , 2000, Journal of the National Cancer Institute.
[58] K. M. Popov,et al. Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. , 1998, Molecular genetics and metabolism.
[59] J Lippman,et al. MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen. , 1997, Cancer research.
[60] R. Sutherland,et al. Inducible overexpression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogens. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[61] K. M. Popov,et al. Cloning and Characterization of PDK4 on 7q21.3 Encoding a Fourth Pyruvate Dehydrogenase Kinase Isoenzyme in Human* , 1996, The Journal of Biological Chemistry.
[62] P. Frey. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[63] R. Santen,et al. Letrozole (CGS 20267). A phase I study of a new potent oral aromatase inhibitor of breast cancer , 1995, Cancer.
[64] C. Osborne,et al. Mechanisms for tamoxifen resistance in breast cancer: Possible role of tamoxifen metabolism , 1993, The Journal of Steroid Biochemistry and Molecular Biology.
[65] D. Edwards,et al. The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. , 1993, Endocrinology.
[66] W. McGuire,et al. Tamoxifen and the isomers of 4-hydroxytamoxifen in tamoxifen-resistant tumors from breast cancer patients. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[67] C. Benz,et al. Truncated forms of DNA-binding estrogen receptors in human breast cancer. , 1991, The Journal of clinical investigation.
[68] A. Wakeling,et al. A potent specific pure antiestrogen with clinical potential. , 1991, Cancer research.
[69] R. Santen,et al. Medical Adrenalectomy with Aminoglutethimide: Clinical Studies in Postmenopausal Patients with Metastatic Breast Carcinoma , 1978, Annals of surgery.
[70] V. Jordan,et al. Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor. , 1975, European journal of cancer.
[71] A. Long,et al. A human cell line from a pleural effusion derived from a breast carcinoma. , 1973, Journal of the National Cancer Institute.
[72] R. Deberardinis,et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.
[73] Gordon B Mills,et al. Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer. , 2007, The Journal of clinical investigation.
[74] Robert Clarke,et al. The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells. , 2005, Molecular cancer therapeutics.
[75] V. Giguère,et al. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. , 2001, Endocrinology.
[76] A. Oh,et al. Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. , 2001, Molecular endocrinology.
[77] K. M. Popov,et al. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. , 1998, The Biochemical journal.