Role of toll‐like receptors in inflammatory bowel disease

[1]  S. Arora,et al.  Inflammatory Bowel Disease: Epidemiology , 2016 .

[2]  Ta-Chiang Liu,et al.  Genetics and Pathogenesis of Inflammatory Bowel Disease. , 2016, Annual review of pathology.

[3]  R. Hoffman,et al.  Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-κB Signaling Pathway. , 2016, In Vivo.

[4]  R. Shirkoohi,et al.  Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway , 2016, Inflammopharmacology.

[5]  Hua‐Lang Wu,et al.  NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR–IL‐1R signalling axis , 2016, The Journal of pathology.

[6]  U. Vogel,et al.  Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort , 2015, PloS one.

[7]  A. Fanning,et al.  Differential expression of key regulators of Toll‐like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator‐activated receptor gamma? , 2015, Clinical and experimental immunology.

[8]  L. Ferguson,et al.  Extracts of Feijoa Inhibit Toll-Like Receptor 2 Signaling and Activate Autophagy Implicating a Role in Dietary Control of IBD , 2015, PloS one.

[9]  G. Gambassi,et al.  How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology , 2015, Journal of immunology research.

[10]  Sky W. Brubaker,et al.  Innate immune pattern recognition: a cell biological perspective. , 2015, Annual review of immunology.

[11]  Bingrong Liu,et al.  Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis , 2015, Experimental and therapeutic medicine.

[12]  Ying Zou,et al.  Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium. , 2014, International journal of clinical and experimental medicine.

[13]  Xiao-Bin Jia,et al.  The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation. , 2014, International immunopharmacology.

[14]  X. Hou,et al.  Expression and implication of toll-like receptors TLR2, TLR4 and TLR9 in colonic mucosa of patients with ulcerative colitis , 2014, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

[15]  Siva Subramani,et al.  Therapeutic potential of chloroquine in a murine model of inflammatory bowel disease. , 2014, International immunopharmacology.

[16]  R. Lofberg,et al.  Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients , 2014, BMC Gastroenterology.

[17]  A. Kraneveld,et al.  Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis , 2014, Mucosal Immunology.

[18]  David Artis,et al.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis , 2014, Nature Reviews Immunology.

[19]  F. Nagengast,et al.  Over-expression of COX-2 mRNA in colorectal cancer , 2014, BMC Gastroenterology.

[20]  Dong-Hyun Kim,et al.  Penta‐O‐galloyl‐β‐D‐glucose ameliorates inflammation by inhibiting MyD88/NF‐κB and MyD88/MAPK signalling pathways , 2013, British journal of pharmacology.

[21]  R. Löfberg,et al.  Topical Treatment with the Toll-like Receptor Agonist DIMS0150 Has Potential for Lasting Relief of Symptoms in Patients with Chronic Active Ulcerative Colitis by Restoring Glucocorticoid Sensitivity , 2013, Inflammatory bowel diseases.

[22]  L. Zhan,et al.  Curcumin Improves TNBS-Induced Colitis in Rats by Inhibiting IL-27 Expression via the TLR4/NF-κB Signaling Pathway , 2012, Planta Medica.

[23]  S. Vishnupriya,et al.  Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis. , 2012, Human immunology.

[24]  D. Werling,et al.  TLR5 Risk-Associated Haplotype for Canine Inflammatory Bowel Disease Confers Hyper-Responsiveness to Flagellin , 2012, PloS one.

[25]  W. Wood,et al.  Toll‐like receptor 2 (TLR2)‐TLR9 crosstalk dictates IL‐12 family cytokine production in microglia , 2012, Glia.

[26]  J. Yamamoto-Furusho,et al.  Transcript levels of Toll-Like receptors 5, 8 and 9 correlate with inflammatory activity in Ulcerative Colitis , 2011, BMC gastroenterology.

[27]  B. Gun,et al.  The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis , 2011, Immunopharmacology and immunotoxicology.

[28]  D. Werling,et al.  Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease. , 2011, Tissue antigens.

[29]  E. Elinav,et al.  Regulation of the antimicrobial response by NLR proteins. , 2011, Immunity.

[30]  M. Gale,et al.  Immune signaling by RIG-I-like receptors. , 2011, Immunity.

[31]  Sunita M. Jain,et al.  Treatment of inflammatory bowel disease (IBD) , 2011, Pharmacological reports : PR.

[32]  D. Davies,et al.  The structural biology of Toll-like receptors. , 2011, Structure.

[33]  Ahmed Adnan,et al.  Application of Weibull model for survival of patients with gastric cancer , 2011, BMC gastroenterology.

[34]  J. Yamamoto-Furusho,et al.  TLR9 mRNA expression is upregulated in patients with active ulcerative colitis. , 2010, Inflammatory bowel diseases.

[35]  D. Werling,et al.  Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease. , 2010, Veterinary immunology and immunopathology.

[36]  S. Akira,et al.  The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors , 2010, Nature Immunology.

[37]  Elke Cario,et al.  Toll-like receptors in inflammatory bowel diseases: A decade later , 2010, Inflammatory bowel diseases.

[38]  R. Medzhitov Inflammation 2010: New Adventures of an Old Flame , 2010, Cell.

[39]  K. Heller,et al.  Effect of natural commensal‐origin DNA on toll‐like receptor 9 (TLR9) signaling cascade, chemokine IL‐8 expression, and barrier integritiy of polarized intestinal epithelial cells , 2010, Inflammatory bowel diseases.

[40]  Maria T. Abreu,et al.  Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function , 2010, Nature Reviews Immunology.

[41]  Ruyang Zhang,et al.  The Toll-Like Receptor 4 D299G and T399I Polymorphisms Are Associated with Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis , 2010, Digestion.

[42]  W. Junger,et al.  Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury , 2009, Nature.

[43]  P. Wierzbicki,et al.  Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[44]  L. O’Neill,et al.  Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. , 2009, The Biochemical journal.

[45]  R. Xu,et al.  A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. , 2009, American Journal of Physiology - Gastrointestinal and Liver Physiology.

[46]  Zhijian J. Chen,et al.  Ubiquitylation in innate and adaptive immunity , 2009, Nature.

[47]  S. Umemura,et al.  Quantitive Cytokine mRNA Expression Profiles in the Colonic Mucosa of Patients with Steroid Naïve Ulcerative Colitis During Active and Quiescent Disease , 2009, Inflammatory bowel diseases.

[48]  Hong-Wei Sun,et al.  Effects of Trefoil Peptide 3 on Expression of TNF-α, TLR4, and NF-κB in Trinitrobenzene Sulphonic Acid Induced Colitis Mice , 2009, Inflammation.

[49]  M. Oriowo,et al.  Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis , 2009, Molecular and Cellular Biochemistry.

[50]  L. Andresen,et al.  Expression and function of toll-like receptor 8 and Tollip in colonic epithelial cells from patients with inflammatory bowel disease , 2009, Scandinavian journal of gastroenterology.

[51]  J. Berzofsky,et al.  Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. , 2008, Immunity.

[52]  M. Abreu,et al.  What are toll-like receptors and what role may they have in IBD? , 2008, Inflammatory bowel diseases.

[53]  Jie-Oh Lee,et al.  Structures of the toll-like receptor family and its ligand complexes. , 2008, Immunity.

[54]  Judy H. Cho,et al.  The genetics and immunopathogenesis of inflammatory bowel disease , 2008, Nature Reviews Immunology.

[55]  L. Griffiths,et al.  Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population , 2008, Inflammatory bowel diseases.

[56]  S. Kugathasan,et al.  CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population , 2008, Inflammatory bowel diseases.

[57]  P. Rossmann,et al.  Expression of Toll-like Receptor 2 (TLR2), TLR4, and CD14 in Biopsy Samples of Patients With Inflammatory Bowel Diseases: Upregulated Expression of TLR2 in Terminal Ileum of Patients With Ulcerative Colitis , 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[58]  A. Gewirtz,et al.  Toll like receptor-5: protecting the gut from enteric microbes , 2008, Seminars in Immunopathology.

[59]  F. Nagy,et al.  The c.1-260C>T Promoter Variant of CD14 but Not the c.896A>G (p.D299G) Variant of Toll-Like Receptor 4 (TLR4) Genes Is Associated with Inflammatory Bowel Disease , 2007, Digestion.

[60]  F. Cominelli,et al.  Innate and adaptive immune responses related to IBD pathogenesis , 2007, Current gastroenterology reports.

[61]  M. Abreu,et al.  TLR4 signalling in the intestine in health and disease. , 2007, Biochemical Society transactions.

[62]  A. Shelling,et al.  Has Toll-Like Receptor 4 Been Prematurely Dismissed as an Inflammatory Bowel Disease Gene? Association Study Combined With Meta-Analysis Shows Strong Evidence for Association , 2007, The American Journal of Gastroenterology.

[63]  T. Merriman,et al.  TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort , 2007, Journal of gastroenterology and hepatology.

[64]  Jian Huang,et al.  Toll-like receptors in inflammation, infection and cancer. , 2007, International immunopharmacology.

[65]  R. Xavier,et al.  Unravelling the pathogenesis of inflammatory bowel disease , 2007, Nature.

[66]  A. Gewirtz,et al.  Activation of toll‐like receptor 3 protects against DSS‐induced acute colitis , 2007, Inflammatory bowel diseases.

[67]  D. Podolsky,et al.  TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[68]  Makoto Watanabe,et al.  Genetic polymorphisms of CD14 and Toll‐like receptor‐2 (TLR2) in patients with ulcerative colitis , 2007, Journal of gastroenterology and hepatology.

[69]  P. Mannon,et al.  The fundamental basis of inflammatory bowel disease. , 2007, The Journal of clinical investigation.

[70]  F. Obermeier,et al.  Surface Expression of Toll-Like Receptor 9 Is Upregulated on Intestinal Epithelial Cells in Response to Pathogenic Bacterial DNA , 2007, Infection and Immunity.

[71]  A. Marshak‐Rothstein Toll-like receptors in systemic autoimmune disease , 2006, Nature Reviews Immunology.

[72]  R. Xu,et al.  Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. , 2006, Gastroenterology.

[73]  R. Flavell,et al.  Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria , 2006, Proceedings of the National Academy of Sciences.

[74]  K. Tracey,et al.  HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2 , 2006, Shock.

[75]  Jongdae Lee,et al.  Homeostatic Effects of TLR9 Signaling in Experimental Colitis , 2006, Annals of the New York Academy of Sciences.

[76]  F. Powrie,et al.  Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation , 2006, Immunological reviews.

[77]  S. Targan,et al.  Current Limitations of IBD Treatment , 2006, Annals of the New York Academy of Sciences.

[78]  Michael Karin,et al.  Intracellular pattern recognition receptors in the host response , 2006, Nature.

[79]  N. Rezaei Therapeutic targeting of pattern-recognition receptors. , 2006, International immunopharmacology.

[80]  Alexis Peralta,et al.  NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease. , 2006, European cytokine network.

[81]  Y. Naito,et al.  Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice. , 2006, International journal of molecular medicine.

[82]  G. Veres,et al.  Increased expression of Toll‐like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease , 2007, Clinical and experimental immunology.

[83]  J. Rodríguez-Sánchez,et al.  TNFα production to TLR2 ligands in active IBD patients , 2006 .

[84]  Wangxue Chen,et al.  Role of Toll-like receptors in health and diseases of gastrointestinal tract. , 2006, World journal of gastroenterology.

[85]  P. Lakatos,et al.  Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ? , 2006, World journal of gastroenterology.

[86]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[87]  S. Hanauer,et al.  Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities , 2006, Inflammatory bowel diseases.

[88]  H. S. Warren,et al.  Toll-like receptors. , 2005, Critical care medicine.

[89]  Weiyi Peng,et al.  Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function , 2005, Science.

[90]  A. Peña,et al.  Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients , 2005, Postgraduate Medical Journal.

[91]  J. Rask-Madsen,et al.  Expression of Toll‐like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium * , 2005, Clinical and experimental immunology.

[92]  G. Macfarlane,et al.  Toll‐like receptors‐2, ‐3 and ‐4 expression patterns on human colon and their regulation by mucosal‐associated bacteria , 2005, Immunology.

[93]  D. Hommes,et al.  Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients , 2005, Journal of Molecular Medicine.

[94]  A. Crispin,et al.  The Role of Toll‐like Receptor 4 Asp299Gly and Thr399Ile Polymorphisms and CARD15/NOD2 Mutations in the Susceptibility and Phenotype of Crohn's Disease , 2005, Inflammatory bowel diseases.

[95]  G. T. te Meerman,et al.  Association Between Toll‐like Receptor 4 and Inflammatory Bowel Disease , 2005, Inflammatory bowel diseases.

[96]  F. Liew,et al.  Negative regulation of Toll-like receptor-mediated immune responses , 2005, Nature Reviews Immunology.

[97]  D. Persing,et al.  A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease 1 , 2005, The Journal of Immunology.

[98]  M. Gazouli,et al.  Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. , 2005, World journal of gastroenterology.

[99]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[100]  T. Mussack,et al.  Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. , 2004, Clinical immunology.

[101]  F. Guarner,et al.  Discussion on toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. , 2004, Gastroenterology.

[102]  H. Drummond,et al.  NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? , 2004, Genes and Immunity.

[103]  J. Glas,et al.  Crohn's disease is associated with a toll-like receptor-9 polymorphism. , 2004, Gastroenterology.

[104]  K. Van Steen,et al.  Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis , 2004, Gut.

[105]  S. Targan,et al.  Bacterial flagellin is a dominant antigen in Crohn disease , 2004 .

[106]  D. Podolsky,et al.  Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. , 2004, Gastroenterology.

[107]  R. Flavell,et al.  Innate Immunity and Apoptosis in IBD , 2004, Inflammatory bowel diseases.

[108]  M. Fenton,et al.  TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. , 2003, Molecular interventions.

[109]  D. Podolsky,et al.  Intestinal myofibroblasts in innate immune responses of the intestine. , 2003, Gastroenterology.

[110]  T. Joh,et al.  The 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Pravastatin Reduces Disease Activity and Inflammation in Dextran-Sulfate Induced Colitis , 2003, Journal of Pharmacology and Experimental Therapeutics.

[111]  K. Michelsen,et al.  Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut 1 , 2003, The Journal of Immunology.

[112]  Sankar Ghosh,et al.  Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip* , 2002, The Journal of Biological Chemistry.

[113]  P. Godowski,et al.  Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression1 , 2001, The Journal of Immunology.

[114]  S. Akira,et al.  Toll-like receptors: critical proteins linking innate and acquired immunity , 2001, Nature Immunology.

[115]  R. Ulevitch,et al.  Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex , 2001, The Journal of Biological Chemistry.

[116]  J. Gordon,et al.  Commensal Host-Bacterial Relationships in the Gut , 2001, Science.

[117]  H. Wagner,et al.  Toll meets bacterial CpG-DNA. , 2001, Immunity.

[118]  D. Podolsky,et al.  Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease , 2000, Infection and Immunity.

[119]  J. Belaiche,et al.  Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. , 1999, The Journal of clinical endocrinology and metabolism.

[120]  F. Gusovsky,et al.  Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction* , 1999, The Journal of Biological Chemistry.

[121]  L. Cardon,et al.  A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. , 1999, American journal of human genetics.

[122]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[123]  G. Hardiman,et al.  A family of human receptors structurally related to Drosophila Toll. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[124]  I. Mattsby‐Baltzer,et al.  The role of the Lps gene in experimental ulcerative colitis in mice , 1996, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[125]  K. Ewe,et al.  Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD) , 1995, Clinical and experimental immunology.

[126]  Yan Tan 谭 琰,et al.  Expression and implication of toll-like receptors TLR2, TLR4 and TLR9 in colonic mucosa of patients with ulcerative colitis , 2014, Journal of Huazhong University of Science and Technology [Medical Sciences].

[127]  J. Wells,et al.  The role of innate signaling in the homeostasis of tolerance and immunity in the intestine. , 2010, International journal of medical microbiology : IJMM.

[128]  布施 香 Toll-like receptor 9 gene mutation and polymorphisms in Japanese ulcerative colitis patients , 2009 .

[129]  S. Akira,et al.  TLR signaling. , 2006, Current topics in microbiology and immunology.

[130]  MariaGazouli,et al.  Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population , 2005 .

[131]  E. Brint,et al.  Toll-like receptors in inflammation , 2005 .

[132]  S. Targan,et al.  Bacterial flagellin is a dominant antigen in Crohn disease. , 2004, The Journal of clinical investigation.

[133]  A. Krieg,et al.  CpG motifs in bacterial DNA and their immune effects. , 2002, Annual review of immunology.

[134]  G. Gerken,et al.  Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. , 2002, The American journal of pathology.