Registration of 2D Histological Images of Bone Implants with 3D SRµCT Volumes

To provide better insight in bone modeling and remodeling around implants, information is extracted using different imaging techniques. Two types of data used in this project are 2D histological images and 3D SRμCT (synchrotron radiation-based computed microtomography) volumes. To enable a direct comparison between the two modalities and to bypass the time consuming and difficult task of manual annotation of the volumes, registration of these data types is desired. In this paper, we present two 2D---3D intermodal rigid-body registration methods for the mentioned purpose. One approach is based on Simulated Annealing (SA) while the other uses Chamfer Matching (CM). Both methods use Normalized Mutual Information for measuring the correspondence between an extracted 2D-slice from the volume and the 2D histological image whereas the latter approach also takes the edge distance into account for matching the implant boundary. To speed up the process, part of the computations are done on the Graphic Processing Unit. The results show that the CM-approach provides a more reliable registration than the SA-approach. The registered slices with the CM-approach correspond visually well to the histological sections, except for cases where the implant has been damaged.

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