Vasospastic action of hydrogen peroxide in human umbilical artery: Relation to protein kinase C and calcium influx

Background. We have demonstrated that hydrogen peroxide (H2O2) potentiated vascular tension in human umbilical artery, perhaps by suppressing the synthesis of nitric oxide and prostacyclin. This study was conducted to evaluate whether the activation of protein kinase C (PKC) or voltage‐dependent calcium channel mediated the vasospastic effect of H2O2

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