Fe∕Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia

Using a water-in-oil microemulsion with cetyl trimethyl ammonium bromide as the surfactant, iron was reduced to form a metallic core on which a passivating oxide shell was grown. Transmission electron microscopy, vibrating sample magnetometry, and heating measurements were used to characterize these monodispersed magnetic Fe∕Fe3O4 composite nanoparticles with respect to the possible application for magnetic hyperthermia treatments of cancer. The aim is to utilize the fact that an iron core (high saturation magnetization) will give a greater heating effect than iron oxide, while the iron oxide coating will allow the nanoparticles to be observed using magnetic resonance imaging so that therapy can be effectively monitored and targeted. The largest specific absorption rate obtained was 345W∕g under an alternating magnetic field of 150Oe at 250kHz.

[1]  P J Hoopes,et al.  Synthesis and heating effect of iron/iron oxide composite and iron oxide nanoparticles , 2007, SPIE BiOS.

[2]  H. Nowak,et al.  Magnetism in Medicine , 2006 .

[3]  Charles R. Sullivan,et al.  Heat deposition in iron oxide and iron nanoparticles for localized hyperthermia , 2006 .

[4]  G. Hadjipanayis,et al.  Magnetic properties of ultrafine iron particles. , 1992, Physical review. B, Condensed matter.

[5]  R. Gilchrist,et al.  Selective Inductive Heating of Lymph Nodes , 1957, Annals of surgery.

[6]  Werner A. Kaiser,et al.  Maghemite nanoparticles with very high AC-losses for application in RF-magnetic hyperthermia , 2004 .

[7]  E. E. Carpenter,et al.  Passivated Iron as Core−Shell Nanoparticles , 2003 .

[8]  Wolfgang Daum,et al.  Application of High Amplitude Alternating Magnetic Fields for Heat Induction of Nanoparticles Localized in Cancer , 2005, Clinical Cancer Research.

[9]  M. Skoglundh,et al.  Kinetics of the Formation of Nano-Sized Platinum Particles in Water-in-Oil Microemulsions. , 2001, Journal of colloid and interface science.

[10]  Catherine C. Berry,et al.  Functionalisation of magnetic nanoparticles for applications in biomedicine , 2003 .

[11]  S. Veintemillas-Verdaguer,et al.  Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging. , 2005, Biomaterials.

[12]  G. Hadjipanayis,et al.  Chemistry of Borohydride Reduction of Iron(II) and Iron(III) Ions in Aqueous and Nonaqueous Media. Formation of Nanoscale Fe, FeB, and Fe2B Powders , 1995 .

[13]  P. Bunn,et al.  Synthesis and evaluation of colloidal magnetic iron oxides for the site-specific radiofrequency-induced hyperthermia of cancer , 1993 .