TAMARIND SEED POLYSACCHARIDE (TSP) - AN ADAPTABLE EXCIPIENT FOR NOVEL DRUG DELIVERY SYSTEMS

Controlled release drug delivery systems are gaining importance in the last few decades for their clinical benefits which are not obtained from conventional oral drug delivery. Hydrophilic matrices involving natural polysaccharides are an interesting option for developing sustained release formulation. One of such polysaccharides is Tamarind seed polysaccharide (TSP) isolated from seed kernel of Tamarindus indica. Although TSP is used as an ingredient in food materials, it has not been extensively evaluated till date for its utility in pharmaceuticals formulations. So, this review mainly focuses on the utility of TSP as an excipient in novel drug delivery systems.

[1]  Sougata Jana,et al.  DEVELOPMENT AND EVALUATION OF EPICHLOROHYDRIN CROSS-LINKED MUCOADHESIVE PATCHES OF TAMARIND SEED POLYSACCHARIDE FOR BUCCAL APPLICATION , 2010 .

[2]  A. Bhosale,et al.  Evaluation of tamarind seed polysaccharide (TSP) as a mucoadhesive and sustained release component of nifedipine buccoadhesive tablet & comparison with HPMC and Na CMC. , 2009 .

[3]  R. V. Kulkarni,et al.  Development and evaluation of xyloglucan matrix tablets containing naproxen , 2008 .

[4]  M. Rolando,et al.  Establishing the tolerability and performance of tamarind seed polysaccharide (TSP) in treating dry eye syndrome: results of a clinical study , 2007, BMC ophthalmology.

[5]  R. Datta A NEW NASAL DRUG DELIVERY SYSTEM FOR DIAZEPAM USING NATURAL MUCOADHESIVE POLYSACCHARIDE OBTAINED FROM TAMARIND SEEDS , 2006 .

[6]  G. Kulkarni,et al.  Development of Controlled Release Spheriods using Natural Polysaccharide as Release Modifier , 2005, Drug delivery.

[7]  E. Ghelardi,et al.  A Mucoadhesive Polymer Extracted from Tamarind Seed Improves the Intraocular Penetration and Efficacy of Rufloxacin in Topical Treatment of Experimental Bacterial Keratitis , 2004, Antimicrobial Agents and Chemotherapy.

[8]  A. Ray,et al.  ROLE OF MODULATING FACTORS ON RELEASE OF CAFFEINE FROM TAMARIND SEED POLYSACCHARIDE TABLETS , 2003 .

[9]  G. Khan Controlled Release Oral Dosage Forms: Some Recent Advances in Matrix Type Drug Delivery Systems , 2001 .

[10]  E. Ghelardi,et al.  Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits. , 2000, The Journal of antimicrobial chemotherapy.

[11]  N. B. Shankaracharya Tamarind - chemistry, technology and uses - a critical appraisal. , 1998 .

[12]  A. Dwivedi,et al.  PERFORMANCE EVALUATION OF TAMARIND SEED POLYOSE AS A BINDER AND IN SUSTAINED RELEASE FORMULATIONS OF LOW DRUG LOADING , 1998 .

[13]  R. K. Khar,et al.  Evaluation of guar gum in the preparation of sustained-release matrix tablets. , 1998, Drug development and industrial pharmacy.

[14]  A. Dwivedi,et al.  Tamarind Seed Polyose : A Potential Polysaccharide For Sustained Release Of Verapamil Hydrochloride As a Model Drug , 1997 .

[15]  D. L. Munday,et al.  Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulations , 1996 .

[16]  T. Nagai,et al.  In vitro and in vivo nasal mucoadhesion of some water-soluble polymers , 1996 .

[17]  J. Jacobsen,et al.  Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine , 1996 .

[18]  T. Shirai,et al.  Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice. , 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[19]  P. Colombo,et al.  Natural Polymer Hydrophilic Matrix: Influencing Drug Release Factors , 1994 .

[20]  W. Burchard,et al.  Investigations on the solution architecture of carboxylated tamarind seed polysaccharide by static and dynamic light scattering , 1993 .

[21]  J. Plaizier-Vercammen,et al.  Evaluation of Xanthan Cum as a Hydrophilic Matrix for Controlled-Release Dosage form Preparations , 1993 .

[22]  M. Ligtenberg,et al.  Cell membrane-associated mucins and their adhesion-modulating property. , 1992, Trends in biochemical sciences.

[23]  John E. Hogan,et al.  Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets , 1987 .

[24]  M. Saettone,et al.  Evaluation of a dynamic permeation technique for studying drug-macromolecule interactions. , 1975, Journal of pharmaceutical sciences.