PIG FARMS AND THEIR SURROUNDINGS AS A FACTOR IN THE SPREAD OF ANTIMICROBIAL RESISTANCE

In recent decades, in modern intensive animal husbandry, there has been a worrying trend towards the selection and spread of bacterial strains resistant to antibiotics. This global phenomenon has not only a certain negative effect on therapeutic practice, but also poses a serious risk to the spread of resistance in the food chain and in humans. Various genera from the family Enterobacteria like Salmonella, Shigella, Klebsiella, Yersinia, Citrobacter, etc. and especially Escherichia coli have a special place in this process. The most commonly used antibiotics for treatment of patients with complicated Salmonella infections are ceftriaxone and ciprofloxacin, to which the bacteria has already developed antibiotic resistance. For Escherichia coli, significantly increased resistance is developed to the third-generation cephalosporins, aminoglycosides, as well as combined resistance to three key antimicrobial groups (fluoroquinolones, third-generation cephalosporins and aminoglycosides). Resistance among Yersinia spp. against tetracyclines and fluorochinolones has been reported to the scientific community in numerous studies on human and animal isolates. By using the raw manure as fertilizer, these microorganisms may be transmitted to soil, wastewater or others environmental niches. Further, they can be transmitted via the food chain to humans and animals. Considering that the horizontal gene transfer is one of the most important mechanisms for transmitting of antimicrobial resistance, then after consumption of contaminated food, water, etc., genetically determined antibiotic resistance in animals can easily affect resistance among people, which makes vital drugs ineffective against serious illnesses. For the possible spread of antimicrobial resistance in pigs and related ecological niches - pig farms, manure lagoons, wastewater and soils, large-scale studies are being conducted to clarify their ecological and health significance. In addition, the results obtained will contribute to the development of an effective national strategy for the control of antimicrobial resistance.

[1]  V. Kussovski,et al.  Prevalence of Antibiotic-Resistant Escherichia coli Isolated from Swine Faeces and Lagoons in Bulgaria , 2021, Antibiotics.

[2]  Xiaoting Li,et al.  The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China , 2020, BMC Veterinary Research.

[3]  M. Zhang,et al.  Microbial diversity and antibiotic resistome in swine farm environments. , 2019, The Science of the total environment.

[4]  K. Nagy,et al.  The European Union summary report on trends and sources of zoonoses, zoonotic agents and food‐borne outbreaks in 2017 , 2018, EFSA journal. European Food Safety Authority.

[5]  P. Raymond,et al.  Diversity of Yersinia enterocolitica isolated from pigs in a French slaughterhouse over 2 years , 2018, MicrobiologyOpen.

[6]  F. Piras,et al.  Prevalence, bioserotyping and antibiotic resistance of pathogenic Yersinia enterocolitica detected in pigs at slaughter in Sardinia. , 2018, International journal of food microbiology.

[7]  M. Liao,et al.  Highly Prevalent Multidrug-Resistant Salmonella From Chicken and Pork Meat at Retail Markets in Guangdong, China , 2018, Front. Microbiol..

[8]  A. Aspán,et al.  Prevalence of human pathogenic Yersinia enterocolitica in Swedish pig farms , 2018, Acta Veterinaria Scandinavica.

[9]  N. Indrawattana,et al.  Staphylococcus argenteus from rabbits in Thailand , 2018, MicrobiologyOpen.

[10]  E. Garner,et al.  Stormwater loadings of antibiotic resistance genes in an urban stream. , 2017, Water research.

[11]  Chantal Quinten,et al.  ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food‐producing animals , 2017, EFSA journal. European Food Safety Authority.

[12]  Y. Park,et al.  Prevalence and Mechanism of Fluoroquinolone Resistance in Escherichia coli Isolated from Swine Feces in Korea. , 2017, Journal of food protection.

[13]  P. He,et al.  Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age. , 2016, Water research.

[14]  K. Lange,et al.  Antibiotic Resistance Genes in Freshwater Biofilms May Reflect Influences from High-Intensity Agriculture , 2016, Microbial Ecology.

[15]  J. Prescott.  The resistance tsunami, antimicrobial stewardship, and the golden age of microbiology. , 2014, Veterinary microbiology.

[16]  Elisabetta Di Giannatale,et al.  Characterization of Antimicrobial Resistance Patterns and Detection of Virulence Genes in Campylobacter Isolates in Italy , 2014, Sensors.

[17]  A. P. Williams,et al.  The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. , 2013, The Lancet. Infectious diseases.

[18]  M. Arabi,et al.  Identification of antibiotic-resistance-gene molecular signatures suitable as tracers of pristine river, urban, and agricultural sources. , 2010, Environmental science & technology.

[19]  F. Aarestrup,et al.  Antimicrobial resistance in swine production , 2008, Animal Health Research Reviews.

[20]  F. Aarestrup,et al.  Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002 – 2004: the ARBAO-II study , 2008, Acta veterinaria Scandinavica.

[21]  P. McDermott,et al.  Characterization of multidrug resistant Salmonella recovered from diseased animals. , 2007, Veterinary microbiology.

[22]  T. Jemmi,et al.  Antimicrobial resistance of Yersinia enterocolitica strains from human patients, pigs and retail pork in Switzerland. , 2007, International journal of food microbiology.

[23]  S. McEwen,et al.  Antimicrobial Resistance and Virulence Genes of Escherichia coli Isolates from Swine in Ontario , 2005, Applied and Environmental Microbiology.

[24]  T. Asai,et al.  Antimicrobial susceptibility of pathogenic Escherichia coli isolated from sick cattle and pigs in Japan. , 2005, The Journal of veterinary medical science.

[25]  Y. Tamura,et al.  Antimicrobial susceptibility of Salmonella isolated from cattle, swine and poultry (2001-2002): report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program. , 2004, The Journal of antimicrobial chemotherapy.

[26]  Yung-Fu Chang,et al.  Antimicrobial Susceptibility of Actinobacillus Pleuropneumoniae, Escherichia Coli, and Salmonella Choleraesuis Recovered from Taiwanese Swine , 2002, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[27]  K. Thong,et al.  Genetic diversity, virulotyping and antimicrobial resistance susceptibility of Yersinia enterocolitica isolated from pigs and porcine products in Malaysia. , 2018, Journal of the science of food and agriculture.

[28]  Maya Gulubova,et al.  MINIMAL RESIDUAL DISEASE IN EARLY COLORECTAL CARCINOMA , 2014 .

[29]  J. Balcázar,et al.  The role of aquatic ecosystems as reservoirs of antibiotic resistance. , 2014, Trends in microbiology.

[30]  Valentina Rizzi,et al.  The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2010. , 2012, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[31]  F. Weill,et al.  Supplement 2003-2007 (No. 47) to the White-Kauffmann-Le Minor scheme. , 2010, Research in microbiology.

[32]  Efsa Publication,et al.  The Community Summary Report on Trends and Sources of Zoonoses in 2008 , 2010 .