Direct immunofluorescence in pyoderma gangrenosum

Direct immunofluorescence was done in fifty‐one cases of pyoderma gangrenosum. Biopsy specimens were taken from the peripheral erythematous zone of the lesion. In thirty‐one cases (61%), there was positive immunofluorescence, with perivascular deposition of immune reactants being the most frequent pattern (twenty‐seven cases). These findings support a vasculitic pathogenesis of pyoderma gangrenosum.

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