The role of zinc in genomic stability.

[1]  J. Tischfield,et al.  Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks , 2011, PloS one.

[2]  M. Fenech,et al.  The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line. , 2011, Mutation research.

[3]  L. Keinan-Boker [Notes from the AICR annual research conference on food, nutrition, physical activity and cancer: November 5-6, 2009, Washington, DC]. , 2010, Harefuah.

[4]  M. Fenech,et al.  Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future. , 2010, The American journal of clinical nutrition.

[5]  W. Thompson,et al.  Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells. , 2010, Chemical research in toxicology.

[6]  T. Donahue,et al.  The ZIP4 pathway in pancreatic cancer , 2010, Cancer biology & therapy.

[7]  E. Ho,et al.  Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. , 2009, The Journal of nutrition.

[8]  M. L. Mathias,et al.  Induction of micronuclei and sister chromatid exchange in bone-marrow cells and abnormalities in sperm of Algerian mice (Mus spretus) exposed to cadmium, lead and zinc. , 2009, Mutation research.

[9]  J. King,et al.  Dietary zinc restriction and repletion affects DNA integrity in healthy men. , 2009, The American journal of clinical nutrition.

[10]  R. Cousins,et al.  Mammalian zinc transporters: nutritional and physiologic regulation. , 2009, Annual review of nutrition.

[11]  M. Blasco,et al.  Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[12]  Han-Woong Lee,et al.  Essential role of p53 in TPEN‐induced neuronal apoptosis , 2009, FEBS letters.

[13]  M. Fenech,et al.  The effect of selenium, as selenomethionine, on genome stability and cytotoxicity in human lymphocytes measured using the cytokinesis-block micronucleus cytome assay. , 2009, Mutagenesis.

[14]  J. Błasiak,et al.  Zinc salts differentially modulate DNA damage in normal and cancer cells , 2009, Cell biology international.

[15]  R. Nicholson,et al.  Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation. , 2009, Trends in molecular medicine.

[16]  D. Hammond,et al.  Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells. , 2009, Toxicology and applied pharmacology.

[17]  S. Bell,et al.  The Metallothionein/Thionein System: An Oxidoreductive Metabolic Zinc Link , 2009, Chembiochem : a European journal of chemical biology.

[18]  C. Tohyama,et al.  Protective role of metallothionein in bone marrow injury caused by X-irradiation. , 2008, The Journal of toxicological sciences.

[19]  J. Weigelt,et al.  Zinc binding catalytic domain of human tankyrase 1. , 2008, Journal of molecular biology.

[20]  S. Kanoni,et al.  Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: Interactive influence of +647 MT1a and −174 IL-6 polymorphic alleles , 2008, Experimental Gerontology.

[21]  S. Kanoni,et al.  Zinc deficiency and IL-6 −174G/C polymorphism in old people from different European countries: Effect of zinc supplementation. ZINCAGE study , 2008, Experimental Gerontology.

[22]  W. Maret,et al.  Possible roles of zinc nutriture in the fetal origins of disease , 2008, Experimental Gerontology.

[23]  G. Dedoussis,et al.  Effect of zinc on cellular poly(ADP-ribosyl)ation capacity , 2008, Experimental Gerontology.

[24]  P. Mecocci,et al.  Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects , 2008, Experimental Gerontology.

[25]  A. Prasad,et al.  Zinc in Human Health: Effect of Zinc on Immune Cells , 2008, Molecular medicine.

[26]  Michael Fenech,et al.  Genome-health nutrigenomics and nutrigenetics: nutritional requirements or ‘nutriomes’ for chromosomal stability and telomere maintenance at the individual level , 2008, Proceedings of the Nutrition Society.

[27]  E. Ho,et al.  Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. , 2008, The Journal of nutrition.

[28]  R. Matthews,et al.  Metal active site elasticity linked to activation of homocysteine in methionine synthases , 2008, Proceedings of the National Academy of Sciences.

[29]  S. Petrucco,et al.  Structural recognition of DNA by poly(ADP‐ribose)polymerase‐like zinc finger families , 2008, The FEBS journal.

[30]  M. Ohno,et al.  Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs , 2008, The EMBO journal.

[31]  F. Marcellini,et al.  Zinc, Metallothioneins, and Longevity: , 2007, Annals of the New York Academy of Sciences.

[32]  M. Fenech Nutrition and genome health. , 2007, Forum of nutrition.

[33]  R. Bruno,et al.  Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes. , 2007, The Journal of nutritional biochemistry.

[34]  W. Maret,et al.  The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling. , 2007, Archives of biochemistry and biophysics.

[35]  S. Sensi,et al.  Mechanism and Regulation of Cellular Zinc Transport , 2007, Molecular medicine.

[36]  M. Fenech Cytokinesis-block micronucleus cytome assay , 2007, Nature Protocols.

[37]  C. Caruso,et al.  Zinc and Inflammatory/Immune Response in Aging , 2007, Annals of the New York Academy of Sciences.

[38]  B. Hang,et al.  Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair. , 2006, Toxicology letters.

[39]  Yong Seok Lee,et al.  Antiproliferative and apoptotic effects of zinc-citrate compound (CIZAR(R)) on human epithelial ovarian cancer cell line, OVCAR-3. , 2006, Gynecologic oncology.

[40]  M. Cardelli,et al.  Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population , 2006, Biogerontology.

[41]  A. Zijno,et al.  Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes. , 2006, Mutagenesis.

[42]  W. Maret,et al.  Zinc requirements and the risks and benefits of zinc supplementation. , 2006, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[43]  Yen-Hui Chen,et al.  Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells. , 2006, Nutrition.

[44]  C. Keen,et al.  Zinc deficiency‐induced cell death , 2005, IUBMB life.

[45]  M. Vašák Advances in metallothionein structure and functions. , 2005, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[46]  O. Bagasra,et al.  hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer , 2005, Molecular Cancer.

[47]  M. Blasco Telomeres and human disease: ageing, cancer and beyond , 2005, Nature Reviews Genetics.

[48]  M. Fenech The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. , 2005, Mutagenesis.

[49]  C. Hogstrand,et al.  ZINC-mediated gene expression offers protection against H2O2-induced cytotoxicity. , 2005, Toxicology and applied pharmacology.

[50]  J. Finley Proposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds. , 2005, Annals of botany.

[51]  P. Yaswen,et al.  Cancer and aging: the importance of telomeres in genome maintenance. , 2005, The international journal of biochemistry & cell biology.

[52]  Stephen P. Jackson,et al.  Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage , 2005, Nature.

[53]  C. Lengauer,et al.  Aneuploidy and cancer , 2004, Nature.

[54]  E. Ho Zinc deficiency, DNA damage and cancer risk. , 2004, The Journal of nutritional biochemistry.

[55]  Hong Wang,et al.  Effects of trace elements on the telomere lengths of hepatocytes L-02 and hepatoma cells SMMC-7721 , 2004, Biological Trace Element Research.

[56]  J. Milner Molecular targets for bioactive food components. , 2004, The Journal of nutrition.

[57]  J. Surrallés,et al.  Telomere dysfunction in genome instability syndromes. , 2004, Mutation research.

[58]  E. Jourdan,et al.  Zinc‐metallothionein genoprotective effect is independent of the glutathione depletion in HaCaT keratinocytes after solar light irradiation , 2004, Journal of cellular biochemistry.

[59]  Peter A. Jones,et al.  Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.

[60]  C. Franceschi,et al.  The −174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing , 2004, Experimental Gerontology.

[61]  B. Ames,et al.  Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. , 2003, The Journal of nutrition.

[62]  B. Richardson Impact of aging on DNA methylation , 2003, Ageing Research Reviews.

[63]  Stephen J. Elledge,et al.  Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes , 2003, Science.

[64]  R. Cousins,et al.  Regulation of zinc metabolism and genomic outcomes. , 2003, The Journal of nutrition.

[65]  C. Franceschi,et al.  Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply , 2003, Mechanisms of Ageing and Development.

[66]  B. Ames,et al.  Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[67]  D. Schild,et al.  Recombinational DNA repair and human disease. , 2002, Mutation research.

[68]  M. Fenech Chromosomal biomarkers of genomic instability relevant to cancer. , 2002, Drug discovery today.

[69]  A. Favier,et al.  Effects of cadmium and zinc on solar-simulated light-irradiated cells: potential role of zinc-metallothionein in zinc-induced genoprotection. , 2002, Archives of biochemistry and biophysics.

[70]  P. Oteiza,et al.  Low Intracellular Zinc Impairs the Translocation of Activated NF-κB to the Nuclei in Human Neuroblastoma IMR-32 Cells* , 2002, The Journal of Biological Chemistry.

[71]  B. Ames,et al.  Are vitamin and mineral deficiencies a major cancer risk? , 2002, Nature Reviews Cancer.

[72]  J. C. Evans,et al.  Betaine-homocysteine methyltransferase: zinc in a distorted barrel. , 2002, Structure.

[73]  Archana Sharma,et al.  Induction of micronuclei by zinc in human leukocytes , 2002, Biological Trace Element Research.

[74]  M. Fenech,et al.  Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[75]  M. Salgueiro,et al.  The role of zinc in the growth and development of children. , 2002, Nutrition.

[76]  E. Mariani,et al.  MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans , 2002, Experimental Gerontology.

[77]  A. Favier,et al.  Zinc resistance impairs sensitivity to oxidative stress in HeLa cells: protection through metallothioneins expression. , 2001, Free radical biology & medicine.

[78]  G. Tell,et al.  Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas. , 2001, Anticancer research.

[79]  G. Eisenbrand,et al.  Mutagenic and cytotoxic effectiveness of zinc dimethyl and zinc diisononyldithiocarbamate in human lymphocyte cultures. , 2001, Mutation research.

[80]  P. Hainaut,et al.  Zinc binding and redox control of p53 structure and function. , 2001, Antioxidants & redox signaling.

[81]  M. Karin,et al.  AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. , 2001, IUBMB life.

[82]  T. Kerppola,et al.  Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity , 2001, Oncogene.

[83]  M. Karin,et al.  AP-1 in cell proliferation and survival , 2001, Oncogene.

[84]  M. Fenech,et al.  Vitamins/minerals and genomic stability in humans. , 2001, Mutation research.

[85]  I E Dreosti,et al.  Zinc and the gene. , 2001, Mutation research.

[86]  B. Ames,et al.  DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. , 2001, Mutation research.

[87]  A. Federico,et al.  Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract† , 2001, European Journal of Clinical Nutrition.

[88]  T. Lange,et al.  Tankyrase promotes telomere elongation in human cells , 2000, Current Biology.

[89]  G. Fritz Human APE/Ref-1 protein. , 2000, The international journal of biochemistry & cell biology.

[90]  N D Marchenko,et al.  Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.

[91]  J. Radicella,et al.  The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. , 2000, Archives of biochemistry and biophysics.

[92]  S. Powell The antioxidant properties of zinc. , 2000, The Journal of nutrition.

[93]  J. G. Penland,et al.  History of zinc as related to brain function. , 2000, The Journal of nutrition.

[94]  B. Ames,et al.  Paracelsus to parascience: the environmental cancer distraction. , 2000, Mutation research.

[95]  B. Ames Micronutrient Deficiencies: A Major Cause of DNA Damage , 1999, Annals of the New York Academy of Sciences.

[96]  M. Toborek,et al.  Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. , 1999, Nutrition.

[97]  A. Breksa,et al.  Recombinant human liver betaine-homocysteine S-methyltransferase: identification of three cysteine residues critical for zinc binding. , 1999, Biochemistry.

[98]  P. Oteiza,et al.  Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. , 1999, Toxicology.

[99]  M. Prakash Hande,et al.  Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability , 1999, Nature Genetics.

[100]  B. Ames Micronutrients prevent cancer and delay aging. , 1998, Toxicology letters.

[101]  A. Prasad Zinc deficiency in humans: a neglected problem. , 1998, Journal of the American College of Nutrition.

[102]  T. Lange,et al.  Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. , 1998, Science.

[103]  A. Prasad Zinc and immunity , 1998, Molecular and Cellular Biochemistry.

[104]  Kenneth H. Falchuk,et al.  The molecular basis for the role of zinc in developmental biology , 1998, Molecular and Cellular Biochemistry.

[105]  F. Beck,et al.  Nutritional and zinc status of head and neck cancer patients: an interpretive review. , 1998, Journal of the American College of Nutrition.

[106]  M. Black Zinc deficiency and child development. , 1998, The American journal of clinical nutrition.

[107]  R. Black Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. , 1998, The American journal of clinical nutrition.

[108]  E. Li,et al.  Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. , 1998, Nucleic acids research.

[109]  R. Cousins,et al.  Mammalian zinc transporters. , 1998, Annual review of nutrition.

[110]  J. Cidlowski,et al.  Cell cycle regulation and apoptosis. , 1998, Annual review of physiology.

[111]  R. Matthews,et al.  Enzyme-catalyzed methyl transfers to thiols: the role of zinc. , 1997, Current opinion in chemical biology.

[112]  K. Huebner,et al.  Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes. , 1997, Carcinogenesis.

[113]  B. Bay,et al.  Adding Zn2+ induces DNA fragmentation and cell condensation in cultured human Chang liver cells , 1997, Biological Trace Element Research.

[114]  S. Broitman,et al.  Esophageal carcinogenesis in the rat: zinc deficiency, DNA methylation and alkyltransferase activity. , 1997, Pathobiology : journal of immunopathology, molecular and cellular biology.

[115]  B. Ames,et al.  Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[116]  Bas van Steensel,et al.  Control of telomere length by the human telomeric protein TRF1 , 1997, Nature.

[117]  M. Toborek,et al.  Antiatherogenic properties of zinc: implications in endothelial cell metabolism. , 1996, Nutrition.

[118]  C. Fraga,et al.  Oxidant Defense Systems in Testes from Zinc-Deficient Rats , 1996, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[119]  C. Fraga,et al.  Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. , 1995, The Journal of nutrition.

[120]  B. Ames,et al.  Maternal Dietary Zinc Influences DNA Strand Break and 8-Hydroxy-2′-Deoxyguanosine Levels in Infant Rhesus Monkey Liver , 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[121]  T. Bestor Structure of mammalian DNA methyltransferase as deduced from the inferred amino acid sequence and direct studies of the protein. , 1988, Biochemical Society transactions.

[122]  J. L. Paternáin,et al.  Acute zinc intoxication: comparison of the antidotal efficacy of several chelating agents. , 1988, Veterinary and human toxicology.

[123]  M. Frommer,et al.  CpG islands in vertebrate genomes. , 1987, Journal of molecular biology.

[124]  T. Lipman,et al.  Esophageal zinc content in human squamous esophageal cancer. , 1987, Journal of the American College of Nutrition.

[125]  J. A. Duerre,et al.  Methionine metabolism in isolated perfused livers from rats fed on zinc-deficient and restricted diets , 1986, British Journal of Nutrition.

[126]  J. A. Duerre,et al.  Effect of zinc deficiency on methionine metabolism, methylation reactions and protein synthesis in isolated perfused rat liver. , 1985, The Journal of nutrition.

[127]  J. Kroll,et al.  Copper and zinc deficiencies in association with depression and neurological findings. , 1983, Biological psychiatry.

[128]  Hambridge Km Zinc and chromium in human nutrition. , 1978 .

[129]  M. Fenech,et al.  Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. , 2011, Mutagenesis.

[130]  E. Ho,et al.  Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise. , 2010, Free radical biology & medicine.

[131]  S. Mitra,et al.  Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells , 2008, Cell Research.

[132]  M. Y. Kim,et al.  Cytotoxic effect of zinc-citrate compound on choriocarcinoma cell lines. , 2007, Placenta.

[133]  M. Salgueiro,et al.  Zinc deficiency and growth , 2007, Biological Trace Element Research.

[134]  M. Fenech,et al.  Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. , 2004, The Journal of nutrition.

[135]  P. Oteiza,et al.  Short-term zinc deficiency affects nuclear factor-kappab nuclear binding activity in rat testes. , 2001, The Journal of nutrition.

[136]  M. Toborek,et al.  Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. , 2000, The American journal of clinical nutrition.

[137]  Zuo-Feng Zhang,et al.  Adenocarcinomas of the esophagus and gastric cardia: the role of diet. , 1997, Nutrition and cancer.

[138]  W. Bettger,et al.  The physiological role of zinc as an antioxidant. , 1990, Free radical biology & medicine.