Analytic determination of the resolution-equivalent effective diameter of a pinhole collimator

To account for photon penetration, the formulas used to calculate the geometric resolution of a pinhole collimator use an equivalent diameter d/sub e/ rather than the physical diameter of the aperture. The expression commonly used for d/sub e/, however, was originally derived to account for penetration in sensitivity calculations. In this paper, we show that the concept of equivalent diameter is also applicable to resolution calculations, propose angular-dependent expressions for d/sub e/ specific to resolution calculations, and discuss the limits of their applicability and how they compare to other expressions. Results show that for normal incidence Paix's expression for d/sub e/ tends to overestimate the resolution-equivalent diameter for full-width-at-half-maximum resolution, whereas Anger's is a better approximation, but may produce underestimates for submillimeter resolution imagers, especially in the case of high-energy photons. For grazing incidence, both expressions may result in significant overestimates.

[1]  Simon R. Cherry,et al.  Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[2]  Ronald J. Jaszczak,et al.  Evaluation of a pinhole collimator for I-131 SPECT head imaging , 1996 .

[3]  T. Turkington,et al.  Uranium pinhole collimators for 511-keV photon SPECT imaging of small volumes , 2001 .

[4]  Ronald J. Jaszczak,et al.  Pinhole SPECT for imaging In-111 in the head , 1994, International Conference on Network and System Security.

[5]  Koichi Ogawa,et al.  Ultra high resolution pinhole SPECT for small animal study , 1998 .

[6]  E. Hoffman,et al.  Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals , 2002 .

[7]  Ronald J. Jaszczak,et al.  Analytic determination of the pinhole collimator's point-spread function and RMS resolution with penetration , 2001, 2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310).

[8]  P M Wanet,et al.  Physical and clinical evaluation of high-resolution thyroid pinhole tomography. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  D R Gilland,et al.  Quantitative imaging of iodine-131 distributions in brain tumors with pinhole SPECT: a phantom study. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  R. Jaszczak,et al.  The effect of gamma ray penetration on angle-dependent sensitivity for pinhole collimation in nuclear medicine. , 1997, Medical physics.

[11]  R. Clackdoyle,et al.  Characterization of a pinhole tomograph with 180/spl deg/ acquisition , 1999 .

[12]  J. H. Hubbell,et al.  XCOM: Photon Cross Section Database (version 1.2) , 1999 .

[13]  R. Jaszczak,et al.  Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. , 1994, Physics in medicine and biology.

[14]  J. Mallard,et al.  The performance of a gamma camera for the visualization of radioactive isotope in vivo. , 1963, Physics in medicine and biology.

[15]  Yuchen Yan,et al.  A system for the 3D reconstruction of retracted-septa PET data using the EM algorithm , 1995 .

[16]  R J Jaszczak,et al.  Breast tumour imaging using incomplete circular orbit pinhole SPET: a phantom study. , 1997, Nuclear medicine communications.

[17]  Yong Choi,et al.  Optimization of pinhole collimator for small animal SPECT using Monte Carlo simulation , 2002 .

[18]  Giovanni Mettivier,et al.  Design of a compact gamma camera with semiconductor hybrid pixel detectors: imaging tests with a pinhole collimator , 2003 .

[19]  P. Acton,et al.  Quantification of dopamine transporters in the mouse brain using ultra-high resolution single-photon emission tomography , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[20]  P Hendrik Pretorius,et al.  Introduction to the physics of molecular imaging with radioactive tracers in small animals , 2002, Journal of cellular biochemistry. Supplement.

[21]  Ronald J. Jaszczak,et al.  Analytic determination of pinhole collimator sensitivity with penetration , 2001, IEEE Transactions on Medical Imaging.

[22]  H. Atkins,et al.  Pinhole SPECT: an approach to in vivo high resolution SPECT imaging in small laboratory animals. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  P. Voorn,et al.  Imaging of dopamine transporters in rats using high-resolution pinhole single-photon emission tomography , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[24]  Freek J. Beekman,et al.  Efficient fully 3-D iterative SPECT reconstruction with Monte Carlo-based scatter compensation , 2002, IEEE Transactions on Medical Imaging.

[25]  D Paix,et al.  Pinhole imaging of gamma rays. , 1967, Physics in medicine and biology.

[26]  B. Welch,et al.  Optimizing pinhole and parallel hole collimation for scintimammography with compact pixellated detectors , 2002 .

[27]  B.M.W. Tsui,et al.  Imaging characteristics of scintimammography using parallel-hole and pinhole collimators , 1997, 1997 IEEE Nuclear Science Symposium Conference Record.

[28]  K. Erlandsson,et al.  Small animal imaging with pinhole single‐photon emission computed tomography , 1994, Cancer.

[29]  Y. Yonekura,et al.  Ultra-high resolution SPECT system using four pinhole collimators for small animal studies. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[30]  Simon R. Cherry,et al.  Physics in Nuclear Medicine , 1987 .

[31]  H. Anger,et al.  CHAPTER 19 – RADIOISOTOPE CAMERAS , 1967 .

[32]  Freek J. Beekman,et al.  High-resolution emission tomography of small laboratory animals: physics and gamma-astronomy meet molecular biology , 2003 .

[33]  N. Schramm,et al.  High-resolution SPECT using multi-pinhole collimation , 2002, IEEE Nuclear Science Symposium Conference Record.

[34]  Patrick Dupont,et al.  Characterization of pinhole SPECT acquisition geometry , 2003, IEEE Transactions on Medical Imaging.

[35]  H. B. Barber,et al.  Ultra-high-resolution brain SPECT imaging: simulation results , 1992, IEEE Conference on Nuclear Science Symposium and Medical Imaging.