Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep.

[1]  J. Fraser,et al.  A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death , 2021, Intensive Care Medicine Experimental.

[2]  A. Kędziora,et al.  Early postoperative hemodynamic instability after heart transplantation – incidence and metabolic indicators , 2021, BMC Anesthesiology.

[3]  Lucile P. A. Neyton,et al.  Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study , 2021, Physiological reports.

[4]  J. Mascaro,et al.  Pathophysiology of severe primary graft dysfunction in orthotopic heart transplantation , 2021, Clinical transplantation.

[5]  J. Madsen,et al.  IL-6 Directed Therapy in Transplantation , 2021, Current Transplantation Reports.

[6]  A. Voors,et al.  Post‐transplant inotrope score is associated with clinical outcomes after adult heart transplantation , 2021, Clinical transplantation.

[7]  J. Fraser,et al.  Compromised right ventricular contractility in an ovine model of heart transplantation following 24hours donor brain stem death. , 2021, Pharmacological research.

[8]  J. Fraser,et al.  An innovative ovine model of severe cardiopulmonary failure supported by veno-arterial extracorporeal membrane oxygenation , 2021, Scientific Reports.

[9]  V. Tchantchaleishvili,et al.  Machine Perfusion of Donor Organs for Transplantation. , 2020, Artificial organs.

[10]  C. Robertson,et al.  Post‐operative fluid overload as a predictor of hospital and long‐term outcomes in a pediatric heart transplant population , 2020, Pediatric transplantation.

[11]  J. Fraser,et al.  Development and validation of ELISAs for the quantitation of interleukin (IL)-1β, IL-6, IL-8 and IL-10 in ovine plasma. , 2020, Journal of immunological methods.

[12]  J. Fildes,et al.  Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation , 2020, Frontiers in Immunology.

[13]  J. Nilsson,et al.  A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation , 2020, Nature Communications.

[14]  A. Kędziora,et al.  Postoperative Serum Lactate Levels for In-Hospital Mortality Prediction Among Heart Transplant Recipients , 2020, Annals of transplantation.

[15]  J. Fraser,et al.  Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep. , 2020, American journal of respiratory and critical care medicine.

[16]  J. Fraser,et al.  Heart Transplantation From Brain Dead Donors: A Systematic Review of Animal Models , 2020, Transplantation.

[17]  S. Steen,et al.  Intact coronary and myocardial functions after 24 hours of non-ischemic heart preservation , 2020, Scandinavian cardiovascular journal : SCJ.

[18]  K. Liao,et al.  Successful Utilization of Extended Criteria Donor (ECD) Hearts for Transplantation - Results of the OCS™ Heart EXPAND Trial to Evaluate the Effectiveness and Safety of the OCS Heart System to Preserve and Assess ECD Hearts for Transplantation , 2019, The Journal of Heart and Lung Transplantation.

[19]  G. Guyatt,et al.  Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation. , 2019, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[20]  N. Al-Attar,et al.  ISHLT Primary Graft Dysfunction Incidence, Risk Factors, and Outcome: A UK National Study , 2019, Transplantation.

[21]  J. Fraser,et al.  Unintended Consequences: Fluid Resuscitation Worsens Shock in an Ovine Model of Endotoxemia , 2018, American journal of respiratory and critical care medicine.

[22]  R. Axell,et al.  Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage. , 2018, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[23]  L. Lund,et al.  The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time. , 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[24]  S. Rorive,et al.  Roles of inflammation and apoptosis in experimental brain death-induced right ventricular failure. , 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[25]  S. Steen,et al.  Safe orthotopic transplantation of hearts harvested 24 hours after brain death and preserved for 24 hours , 2016, Scandinavian cardiovascular journal : SCJ.

[26]  J. Fraser,et al.  Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury , 2015, Intensive Care Medicine Experimental.

[27]  N. Banner,et al.  Primary Cardiac Allograft Dysfunction—Validation of a Clinical Definition , 2015, Transplantation.

[28]  Pascal Leprince,et al.  Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial , 2015, The Lancet.

[29]  P. Macdonald,et al.  Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series , 2015, The Lancet.

[30]  L. M. Anderson,et al.  Twelve-Hour Hypothermic Machine Perfusion for Donor Heart Preservation Leads to Improved Ultrastructural Characteristics Compared to Conventional Cold Storage. , 2015, Annals of transplantation.

[31]  M. Girabent-Farrés,et al.  Methodological Quality and Reporting of Generalized Linear Mixed Models in Clinical Medicine (2000–2012): A Systematic Review , 2014, PloS one.

[32]  L. M. Anderson,et al.  Preservation of donor hearts using hypothermic oxygenated perfusion. , 2014, Annals of transplantation.

[33]  S. Russell,et al.  Report from a consensus conference on primary graft dysfunction after cardiac transplantation. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[34]  S. Aggarwal,et al.  Vasoactive–inotropic score after pediatric heart transplant: A marker of adverse outcome , 2013, Pediatric transplantation.

[35]  D. Barr,et al.  Random effects structure for confirmatory hypothesis testing: Keep it maximal. , 2013, Journal of memory and language.

[36]  S. Steen,et al.  Pharmacological normalization of circulation after acute brain death , 2012, Acta anaesthesiologica Scandinavica.

[37]  Sunmi Yang,et al.  Critical Role of Proinflammatory Cytokine IL‐6 in Allograft Rejection and Tolerance , 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[38]  B. Burrell,et al.  IL-6 Promotes Cardiac Graft Rejection Mediated by CD4+ Cells , 2011, The Journal of Immunology.

[39]  P. Macdonald,et al.  Primary Graft Failure after Heart Transplantation , 2011, Journal of transplantation.

[40]  M. Jessen,et al.  Machine perfusion for cardiac allograft preservation , 2008, Current opinion in organ transplantation.

[41]  C. Spies,et al.  Prediction of volume response under open-chest conditions during coronary artery bypass surgery , 2007, Critical care.

[42]  Y. Colson,et al.  Graft Produced Interleukin-6 Functions as a Danger Signal and Promotes Rejection After Transplantation , 2007, Transplantation.

[43]  B. Fuller,et al.  Hypothermic perfusion preservation: the future of organ preservation revisited? , 2007, Cryobiology.

[44]  S. Palmisani,et al.  Effects of sternotomy on heart–lung interaction in patients undergoing cardiac surgery receiving pressure‐controlled mechanical ventilation , 2007, Acta anaesthesiologica Scandinavica.

[45]  M. Oz,et al.  The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. , 2007, The Journal of thoracic and cardiovascular surgery.

[46]  J. Rhodin,et al.  Ultrastructure changes associated with brain death in the human donor heart , 1997, Transplant international : official journal of the European Society for Organ Transplantation.

[47]  W. Wicomb,et al.  The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. , 1989, Annals of the Royal College of Surgeons of England.

[48]  K. Bando,et al.  [High energy phosphates and mitochondrial respiratory function after 24 hours cardiac preservation--comparison between simple hypothermic immersion and continuous hypothermic perfusion]. , 1989, Kokyu to junkan. Respiration & circulation.

[49]  A. Rose,et al.  INJURY OF MYOCARDIAL CONDUCTION TISSUE AND CORONARY ARTERY SMOOTH MUSCLE FOLLOWING BRAIN DEATH IN THE BABOON , 1988, Transplantation.