An ensemble framework with $l_{21}$-norm regularized hypergraph laplacian multi-label learning for clinical data prediction

Previous work has shown that machine learning algorithms lend themselves to clinical decision-making and are a valuable tool for physicians. For clinical data, it is often necessary to assign multiple labels to a patient record by choosing from a large number of potential labels. A key problem in learning from multi-labelled data is how to exploit the information contained in the correlations between labels. The hypergraph-based multi-label learning method learns from data by exploiting the spectral property of the hypergraph that encodes the correlation structure of labels. However, the problem with this method is the difficulty with which interpretations can be made. This is mainly due to its inability to recognize the importance of key features in the original feature space. Moreover, it is hard to comprehensively capture the complex structure of the correlations between labels. To overcome these difficulties and improve interpretability, we propose an $l_{21}$-norm regularized Graph Laplacian multi-label learning to perform feature selection and label embedding simultaneously. In-depth experimental studies, using the publicly available Medical Information Mart for Intensive Care (MIMIC-III) database, validate the effectiveness of our approach.