Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues.

[1]  J. Ross,et al.  Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress , 1999, Cell.

[2]  K. Rajewsky,et al.  Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects , 1998, The Journal of experimental medicine.

[3]  G. Freeman,et al.  Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy. , 1998, Immunology letters.

[4]  B. Brar,et al.  Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli. , 1998, Journal of molecular and cellular cardiology.

[5]  C. Henderson,et al.  Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1) , 1998, The Journal of Neuroscience.

[6]  L. Brunton,et al.  Small heat shock proteins and protection against ischemic injury in cardiac myocytes. , 1997, Circulation.

[7]  T. Hirano,et al.  Signaling mechanisms through gp130: a model of the cytokine system. , 1997, Cytokine & growth factor reviews.

[8]  K. Chien,et al.  Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development , 1997, Journal of Molecular Medicine.

[9]  C A Beltrami,et al.  Apoptosis in the failing human heart. , 1997, The New England journal of medicine.

[10]  J. Darnell,et al.  The state of the STATs: recent developments in the study of signal transduction to the nucleus. , 1997, Current opinion in cell biology.

[11]  K. Chien,et al.  Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway , 1997, The Journal of Biological Chemistry.

[12]  S. Chevalier,et al.  Signaling of the Cardiotrophin-1 Receptor , 1997, The Journal of Biological Chemistry.

[13]  W. Wood,et al.  In vivo effects of cardiotrophin-1. , 1996, Cytokine.

[14]  P. Ghezzi,et al.  Cardiotrophin-1 inhibits tumor necrosis factor production in the heart and serum of lipopolysaccharide-treated mice and in vitro in mouse blood cells. , 1996, The American journal of pathology.

[15]  D. Latchman,et al.  Differential protection of primary rat cardiocytes by transfection of specific heat stress proteins. , 1996, Journal of molecular and cellular cardiology.

[16]  P. Anversa,et al.  Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. , 1996, Journal of molecular and cellular cardiology.

[17]  John Calvin Reed,et al.  Programmed myocyte cell death affects the viable myocardium after infarction in rats. , 1996, Experimental cell research.

[18]  R. Vejsada,et al.  Cardiotrophin-1, a Cytokine Present in Embryonic Muscle, Supports Long-Term Survival of Spinal Motoneurons , 1996, Neuron.

[19]  K. Chien,et al.  Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. , 1996, Cytokine & growth factor reviews.

[20]  J. Heath,et al.  Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy , 1996, The Journal of Biological Chemistry.

[21]  W. Wood,et al.  Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. , 1996, Cytokine.

[22]  G. Fantuzzi,et al.  Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. , 1996, Blood.

[23]  K. Nakao,et al.  cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats. , 1996, Biochemical and biophysical research communications.

[24]  K. Chien,et al.  Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. , 1996, Development.

[25]  K. Shiota,et al.  Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[26]  S. Landis,et al.  Cardiotrophin-1 is not the sweat gland-derived differentiation factor , 1995, Neuroreport.

[27]  S. Umansky,et al.  Post-ischemic apoptotic death of rat neonatal cardiomyocytes. , 1995, Cell death and differentiation.

[28]  S. Rose-John,et al.  A new hepatocyte stimulating factor: cardiotrophin‐1 (CT‐1) , 1995, FEBS letters.

[29]  S. Akira,et al.  Interleukin-6 family of cytokines and gp130. , 1995, Blood.

[30]  D S Latchman,et al.  Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells. , 1995, Journal of molecular and cellular cardiology.

[31]  T. Kishimoto,et al.  Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[32]  W. Wood,et al.  Cardiotrophin-1 , 1995, The Journal of Biological Chemistry.

[33]  K. Chien,et al.  Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[34]  R. Kloner,et al.  Reperfusion injury induces apoptosis in rabbit cardiomyocytes. , 1994, The Journal of clinical investigation.

[35]  D. Latchman,et al.  Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress. , 1994, Journal of molecular and cellular cardiology.

[36]  S. Akira,et al.  Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway , 1994, Cell.

[37]  S. Akira,et al.  Cytokine signal transduction , 1994, Cell.

[38]  G. Fantuzzi,et al.  Cytokines in Acute Myocardial Infarction: Selective Increase in Circulating Tumor Necrosis Factor, Its Soluble Receptor, and Interleukin‐1 Receptor Antagonist , 1994, Journal of cardiovascular pharmacology.

[39]  S. Akira,et al.  Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Heinrich,et al.  Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level , 1993, Molecular and cellular biology.

[41]  W. Wood,et al.  Effects of cardiotrophin-1 on haemodynamics and cardiac function in conscious rats. , 1998, Cytokine.

[42]  N. Tamura,et al.  Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms. , 1998, Journal of cardiovascular pharmacology.

[43]  T. Kishimoto,et al.  Gp130 and the interleukin-6 family of cytokines. , 1997, Annual review of immunology.

[44]  S. Akira,et al.  Interleukin 6 activates heat-shock protein 90 beta gene expression. , 1997, The Biochemical journal.

[45]  John Calvin Reed,et al.  Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. , 1996, Laboratory investigation; a journal of technical methods and pathology.