Bone composition and healing: Open electromagnetic and biomechanical problems

In this paper, we present a review of some electromagnetic interactions in bone matter. Special attention is paid to pulsed electromagnetic therapy, which is potentially a promising therapeutic method for bone healing. We review and compare existing setups and their applications.

[1]  R. Puvanakrishnan,et al.  Low frequency pulsed electromagnetic field--a viable alternative therapy for arthritis. , 2009, Indian journal of experimental biology.

[2]  W. R. Thompson,et al.  Mechanical regulation of signaling pathways in bone. , 2012, Gene.

[3]  J. Kanczler,et al.  Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro. , 1998, Biochemical and biophysical research communications.

[4]  H. Frost,et al.  BONE REMODELLING DYNAMICS , 1964 .

[5]  Walter H. Chang,et al.  Pulsed electromagnetic fields affect osteoblast proliferation and differentiation in bone tissue engineering , 2007, Bioelectromagnetics.

[6]  L. Bonewald,et al.  Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[7]  J. Kanczler,et al.  Pulsed Electromagnetic Fields Simultaneously Induce Osteogenesis and Upregulate Transcription of Bone Morphogenetic Proteins 2 and 4 in Rat Osteoblastsin Vitro , 1998 .

[8]  G. Stein,et al.  Transient upregulation of CBFA1 in response to bone morphogenetic protein‐2 and transforming growth factor β1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation , 1999, Journal of cellular biochemistry.

[9]  G. Barabino,et al.  Pulsed electromagnetic fields enhance BMP‐2 dependent osteoblastic differentiation of human mesenchymal stem cells , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  Mohit Bhandari,et al.  Meta-Analysis of Randomized Controlled Trials Electrical Stimulation for Long-Bone Fracture-Healing: A , 2008 .

[11]  Brendan F Boyce,et al.  Biology of RANK, RANKL, and osteoprotegerin , 2007, Arthritis research & therapy.

[12]  M. Pall.  Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects , 2013, Journal of cellular and molecular medicine.

[13]  Gwo‐Jaw Wang,et al.  A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair , 2014, PLoS ONE.

[14]  Dong-Woo Cho,et al.  Electromagnetically controllable osteoclast activity. , 2014, Bone.

[15]  C. Rubin,et al.  Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. , 2011, Journal of biomechanics.

[16]  P. Strauss,et al.  Effects of extremely low frequency electromagnetic field (EMF) on collagen type I mRNA expression and extracellular matrix synthesis of human osteoblastic cells. , 1998, Bioelectromagnetics.

[17]  Walter H. Chang,et al.  Pulsed electromagnetic fields stimulation affects osteoclast formation by modulation of osteoprotegerin, RANK ligand and macrophage colony‐stimulating facto , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[18]  E. Fallentin,et al.  Treatment of knee osteoarthritis with pulsed electromagnetic fields: a randomized, double-blind, placebo-controlled study. , 2005, Osteoarthritis and cartilage.

[19]  D. Hernandez Vaquero,et al.  The Effect of Electromagnetic Stimulation on Nonunions: Myth or Reality? , 2007 .

[20]  L. Gold.  The role for transforming growth factor-beta (TGF-beta) in human cancer. , 1999, Critical reviews in oncogenesis.

[21]  Kye-Yong Song,et al.  Neural stimulation on human bone marrow‐derived mesenchymal stem cells by extremely low frequency electromagnetic fields , 2012, Biotechnology progress.

[22]  Q. Qin.  Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects , 2013 .