Pankreaskarzinom auf dem Boden eines intraduktal papillär-muzinösen Tumors

Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are intraductally located, mucin-producing cystic neoplasms of the pancreas with a malignant potential. We report about a 54-year-old female who underwent segmental resection of the pancreas for non-invasive IPMN. The surgical margins were tumour-negative. Three years later a highly suspicious tumour of the pancreatic tail was detected during routine follow-up. Resection of the pancreatic tail was performed. The histological analysis revealed an adenocarcinoma. This case suggests the development of a pancreatic carcinoma from a non-invasive IPMN and raises the question about the extent of surgery of non-invasive IPMNs of the pancreas.

[1]  N. Adsay,et al.  Cystic Neoplasia of the Pancreas: Pathology and Biology , 2008, Journal of Gastrointestinal Surgery.

[2]  K. Kami,et al.  Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinicopathologic Characteristics and Long-Term Follow-Up After Resection , 2008, World Journal of Surgery.

[3]  T. Kinoshitá,et al.  Surgical Outcome of Intraductal Papillary Mucinous Neoplasms of the Pancreas , 2007, Annals of Surgical Oncology.

[4]  B. Petersen,et al.  Do Consensus Indications for Resection in Branch Duct Intraductal Papillary Mucinous Neoplasm Predict Malignancy? A Study of 147 Patients , 2007, The American Journal of Gastroenterology.

[5]  S. Chari,et al.  International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the Pancreas , 2006, Pancreatology.

[6]  L. Traverso,et al.  Outcomes following resection of invasive and noninvasive intraductal papillary mucinous neoplasms of the pancreas. , 2005, American journal of surgery.

[7]  K. Campbell,et al.  Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience , 2004, Annals of surgery.

[8]  H. Pitt,et al.  Cystic Pancreatic Neoplasms: Observe or Operate , 2004, Annals of surgery.

[9]  C. Bassi,et al.  Main-Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinical Predictors of Malignancy and Long-term Survival Following Resection , 2004, Annals of surgery.

[10]  O. Cummings,et al.  Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms. , 2003, Archives of surgery.

[11]  N. Adsay,et al.  The "new kid on the block": Intraductal papillary mucinous neoplasms of the pancreas: current concepts and controversies. , 2003, Surgery.

[12]  H. Saeger,et al.  Die Therapie gutartiger Tumoren des Pankreas , 2003 .

[13]  S. Kitano,et al.  Optimal Management of the Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas , 2003, Journal of clinical gastroenterology.

[14]  B. Petersen,et al.  Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. , 2002, Gastroenterology.

[15]  J. Scoazec,et al.  Intraductal papillary-mucinous tumors of the pancreas: predictive criteria of malignancy according to pathological examination of 53 cases. , 2002, Archives of surgery.

[16]  J. Scoazec,et al.  Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma , 2002, Gut.

[17]  L. Traverso Surgical treatment of intraductal papillary mucinous neoplasms of the pancreas: The aggressive approach , 2002, Journal of Gastrointestinal Surgery.

[18]  M. Imamura,et al.  Surgical management of intraductal papillary mucinous tumor of the pancreas. , 2002, Surgery.

[19]  K. Lillemoe,et al.  Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Increasingly Recognized Clinicopathologic Entity , 2001, Annals of surgery.

[20]  K. Lillemoe,et al.  Resected adenocarcinoma of the pancreas— 616 patients: Results, outcomes, and prognostic indicators , 2000, Journal of Gastrointestinal Surgery.

[21]  D. Rattner,et al.  Pancreatic mucinous ductal ectasia and intraductal papillary neoplasms. A single malignant clinicopathologic entity. , 1997, Annals of surgery.

[22]  L. Traverso,et al.  Mucus is a predictor of better prognosis and survival in patients with intraductal papillary mucinous tumor of the pancreas , 2003, Journal of Gastrointestinal Surgery.

[23]  K. Ohhashi Four cases of mucin-producing cancer of the pancreas on specific findings of the papilla of Vater , 1982 .