Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain
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Y. Ioannou | Y. Ohsaki | Michitaka Suzuki | S. Kato | M. Vanier | H. Ninomiya | K. Ohno | Y. Kitamura | M. Ueno | J. P. Davies | H. Hosokawa | Y. Sugimoto
[1] N. Mosaffa,et al. Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain. , 2006, European journal of pharmacology.
[2] T. Kielian. Toll‐like receptors in central nervous system glial inflammation and homeostasis , 2006, Journal of neuroscience research.
[3] E. Latz,et al. Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity , 2006, The EMBO journal.
[4] R. Sundler,et al. The role of lipid rafts in LPS-induced signaling in a macrophage cell line. , 2006, Molecular immunology.
[5] Christine M Howison,et al. Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann‐Pick C mice , 2005, Journal of neuroscience research.
[6] Christophe Caux,et al. Recognition of Double-stranded RNA by Human Toll-like Receptor 3 and Downstream Receptor Signaling Requires Multimerization and an Acidic pH* , 2005, Journal of Biological Chemistry.
[7] G. Lynch,et al. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain. , 2005, The American journal of pathology.
[8] H. Weedon,et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis , 2005, Annals of the rheumatic diseases.
[9] JoAnn Buchanan,et al. Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C Disease , 2005, PLoS genetics.
[10] S. Walkley,et al. Consequences of NPC1 and NPC2 loss of function in mammalian neurons. , 2004, Biochimica et biophysica acta.
[11] Shizuo Akira,et al. Toll-like receptor signalling , 2004, Nature Reviews Immunology.
[12] S. Mellon,et al. Niemann–Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone , 2004, Nature Medicine.
[13] R. Medzhitov,et al. Regulation of Phagosome Maturation by Signals from Toll-Like Receptors , 2004, Science.
[14] L. Guillot,et al. Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways , 2004, Journal of Biological Chemistry.
[15] Ryan M. O’Connell,et al. Toll-like Receptors Induce a Phagocytic Gene Program through p38 , 2004, The Journal of experimental medicine.
[16] Danielle A. Simmons,et al. Postnatal development of inflammation in a murine model of Niemann–Pick type C disease: immunohistochemical observations of microglia and astroglia , 2003, Experimental Neurology.
[17] B. Monks,et al. Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction* , 2003, Journal of Biological Chemistry.
[18] Shizuo Akira,et al. Toll-like Receptor Signaling* , 2003, Journal of Biological Chemistry.
[19] Hernan Cardenas,et al. Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice , 2003, Brain Research.
[20] L. Ivashkiv,et al. The JAK/STAT pathway in rheumatoid arthritis: pathogenic or protective? , 2003, Arthritis and rheumatism.
[21] Douglas T. Golenbock,et al. Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction* 210 , 2002, The Journal of Biological Chemistry.
[22] E. Nanba,et al. Niemann–Pick type C disease: Accelerated neurofibrillary tangle formation and amyloid β deposition associated with apolipoprotein E ε4 homozygosity , 2002 .
[23] D. Golenbock,et al. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. , 2002, Journal of cell science.
[24] O. Bernard,et al. Studies on neuronal death in the mouse model of Niemann‐Pick C disease , 2002, Journal of neuroscience research.
[25] M. McNiven,et al. The Antiviral Dynamin Family Member, MxA, Tubulates Lipids and Localizes to the Smooth Endoplasmic Reticulum* , 2002, The Journal of Biological Chemistry.
[26] P. Gebicke-haerter,et al. Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[27] D. German,et al. Neurodegeneration in the Niemann–Pick C mouse: glial involvement , 2002, Neuroscience.
[28] K. Higaki,et al. Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group. , 2001, American journal of human genetics.
[29] K. Higaki,et al. Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[30] E. Ikonen,et al. Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. , 2001, Journal of cell science.
[31] M. Scott,et al. Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. , 2001, Molecular biology of the cell.
[32] J. Hidalgo,et al. Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures , 2001, Neuroscience.
[33] R. Wattiaux,et al. Identification of HE1 as the second gene of Niemann-Pick C disease. , 2000, Science.
[34] K. Yamakawa,et al. Genotype-phenotype relationship of Niemann-Pick disease type C: a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts , 2000, Journal of medical genetics.
[35] K. Takeda,et al. Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages1 , 2000, The Journal of Immunology.
[36] C. Schindler. Cytokines and JAK-STAT signaling. , 1999, Experimental cell research.
[37] R. Brady,et al. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] B. Williams,et al. Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays , 1998 .
[39] N. Reich,et al. Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3* , 1997, The Journal of Biological Chemistry.
[40] W. Pavan,et al. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. , 1997, Science.
[41] K. G. Coleman,et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. , 1997, Science.
[42] J. Ihle. STATs: Signal Transducers and Activators of Transcription , 1996, Cell.
[43] M. Patterson,et al. PART 16 : LYSOSOMAL DISORDERS Chapter 145 : Niemann-Pick Disease Type C : A Lipid Trafficking Disorder , 2007 .
[44] R. Proia,et al. Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. , 2005, Molecular genetics and metabolism.
[45] S. Murayama,et al. Cerebellar degeneration in the Niemann-Pick type C mouse , 2004, Acta Neuropathologica.
[46] B. Ghetti,et al. Neurofibrillary tangles in Niemann-Pick disease type C , 2004, Acta Neuropathologica.