Stathmin Expression in the Placenta and Embryonic Brain

Stathmin is a member of a family of proteins believed to play important roles in neural development. In the current study, expression of stathmin forms in rat brain was examined from day 15 of gestation through the neonatal period and into adulthood. Placental stathmin also was analyzed. Un- phosphorylated and phosphorylated forms of stathmin in the brain are highest in the late fetal and early neonatal period. Placenta expresses some larger stathmin-like proteins, but none of the 19 kilodalton forms of stathmin. The results show that stathmin is greatly elevated during a period of rapid brain growth and development, suggesting that stathmin plays a regulatory role in development. The functional significance of the unique pattern of stathmin-like proteins expressed by the placenta is unclear at this time.

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