Nanotechnology for surgeons.

At first glance it might appear that nanomedicine is irrelevant to surgery as it is practiced today, as surgery is generally concerned with the manipulation of decidedly macroscopic devices. However, surgery as a discipline is obviously not limited to clinical procedures, but dovetails with parallel medical therapeutics. Consequently, methodologies that can enhance overall perioperative care are important. An alternative view is that nanomedicine is perhaps destined to put surgeons out of certain kinds of business--much as minimally invasive techniques including invasive radiology have progressively infringed on clinical areas that were once the purview of more conventional surgical approaches. As is often the case, the truth is somewhere in the middle. In any event nanotechnology certainly has the potential to affect the field. It is important to understand that potential and how it can be harnessed.

[1]  Y. Ikada,et al.  Phagocytosis of polymer microspheres by macrophages , 1990 .

[2]  H. Maeda,et al.  Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[3]  J. M. Harris,et al.  Pegylation: a novel process for modifying pharmacokinetics. , 2001, Clinical pharmacokinetics.

[4]  Matthew J Dalby,et al.  Increasing fibroblast response to materials using nanotopography: morphological and genetic measurements of cell response to 13-nm-high polymer demixed islands. , 2002, Experimental cell research.

[5]  Mehmet Fatih Yanik,et al.  Neurosurgery: Functional regeneration after laser axotomy , 2004, Nature.

[6]  C J Murphy,et al.  Nanoscale topography modulates corneal epithelial cell migration. , 2003, Journal of biomedical materials research. Part A.

[7]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[8]  Kazuyoshi Itoh,et al.  Intracellular disruption of mitochondria in a living HeLa cell with a 76-MHz femtosecond laser oscillator. , 2005, Optics express.

[9]  H. Baac,et al.  Neural prosthesis in the wake of nanotechnology: controlled growth of neurons using surface nanostructures. , 2006, Acta neurochirurgica. Supplement.

[10]  Kwok-Fai So,et al.  Nano hemostat solution: immediate hemostasis at the nanoscale. , 2006, Nanomedicine : nanotechnology, biology, and medicine.

[11]  R. Langer,et al.  Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. , 2006, Journal of biomedical materials research. Part A.

[12]  Babak Ziaie,et al.  An Artificial Nano-Drainage Implant (ANDI) for Glaucoma Treatment , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[13]  R. Langer,et al.  Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model , 2007, Cancer Chemotherapy and Pharmacology.

[14]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[15]  C. Highley,et al.  In Situ Cross-linkable Hyaluronan Hydrogels Containing Polymeric Nanoparticles for Preventing Postsurgical Adhesions , 2007, Annals of surgery.

[16]  Daniel S Kohane,et al.  Microparticles and nanoparticles for drug delivery. , 2007, Biotechnology and bioengineering.

[17]  D. Vestweber,et al.  Nano-surgery at the leukocyte–endothelial docking site , 2007, Pflügers Archiv - European Journal of Physiology.

[18]  Russell J Andrews,et al.  Neuroprotection at the Nanolevel—Part I , 2007, Annals of the New York Academy of Sciences.

[19]  Yun Tang,et al.  Tailoring properties and functionalities of metal nanoparticles through crystallinity engineering. , 2007, Nature materials.

[20]  M. Roukes,et al.  Ultra-sensitive NEMS-based cantilevers for sensing, scanned probe and very high-frequency applications. , 2007, Nature nanotechnology.

[21]  Duncan Sutherland,et al.  Nanomechanotransduction and Interphase Nuclear Organization influence on genomic control , 2007, Journal of cellular biochemistry.

[22]  Russell J Andrews,et al.  Neuroprotection at the Nanolevel—Part II , 2007, Annals of the New York Academy of Sciences.

[23]  C. Mao,et al.  Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra , 2008, Nature.

[24]  Xiaofeng Zhang,et al.  Sub-two nanometer single crystal Au nanowires. , 2008, Nano letters.

[25]  Paul Winterrowd,et al.  Ultra-sensitive detection of bacterial toxin with silicon nanowire transistor. , 2008, Lab on a chip.

[26]  A. de Mel,et al.  Development of cardiovascular bypass grafts: endothelialization and applications of nanotechnology , 2008, Expert review of cardiovascular therapy.

[27]  Robert Langer,et al.  The biocompatibility of mesoporous silicates. , 2008, Biomaterials.

[28]  T. Albrektsson,et al.  The effect of chemical and nanotopographical modifications on the early stages of osseointegration. , 2008, The International journal of oral & maxillofacial implants.

[29]  E. Place,et al.  Complexity in biomaterials for tissue engineering. , 2009, Nature materials.

[30]  M. Roukes,et al.  Toward single-molecule nanomechanical mass spectrometry , 2005, Nature nanotechnology.

[31]  Arun K Iyer,et al.  Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma , 2009, BMC Cancer.

[32]  Ramón Torrecillas,et al.  Nanotechnology in joint replacement. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[33]  Jim E Riviere,et al.  Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[34]  R. Drezek,et al.  Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy , 2010, Breast Cancer Research and Treatment.

[35]  P. Couvreur,et al.  Nanocarriers’ entry into the cell: relevance to drug delivery , 2009, Cellular and Molecular Life Sciences.

[36]  Nano-cryosurgery: advances and challenges. , 2009, Journal of nanoscience and nanotechnology.

[37]  Y. Yan,et al.  The repair of critical-size defects with porous hydroxyapatite/polyamide nanocomposite: an experimental study in rabbit mandibles. , 2010, International journal of oral and maxillofacial surgery.

[38]  Young-tae Kim,et al.  Slow‐release nanoparticle‐encapsulated delivery system for laryngeal injection , 2010, The Laryngoscope.

[39]  Noriaki Ohuchi,et al.  Nano-imaging of the lymph network structure with quantum dots , 2010, Nanotechnology.

[40]  L. Whiteside,et al.  Diamond-like carbon coatings enhance the hardness and resilience of bearing surfaces for use in joint arthroplasty. , 2010, Acta biomaterialia.

[41]  The role of surgeons in identifying emerging technologies for health technology assessment. , 2010, Canadian journal of surgery. Journal canadien de chirurgie.

[42]  C. Lieber,et al.  Design and Implementation of Functional Nanoelectronic Interfaces With Biomolecules, Cells, and Tissue Using Nanowire Device Arrays , 2010, IEEE Transactions on Nanotechnology.

[43]  Brian P. Timko,et al.  Remotely Triggerable Drug Delivery Systems , 2010, Advanced materials.

[44]  Sang Hyun Cho,et al.  Nanoparticle-mediated thermal therapy: Evolving strategies for prostate cancer therapy , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[45]  Miqin Zhang,et al.  Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. , 2010, Advanced drug delivery reviews.

[46]  G. T. Lim,et al.  A nanostructured carbon-reinforced polyisobutylene-based thermoplastic elastomer. , 2010, Biomaterials.

[47]  Tal Dvir,et al.  Nanotechnological strategies for engineering complex tissues. , 2020, Nature nanotechnology.