Clinical evaluation of injectable platelet rich fibrin with connective tissue graft for the treatment of deep gingival recession defects. A controlled randomized clinical trial.

AIM The aim of this study was to determine whether the combined connective tissue graft (CTG) with injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) improved root coverage of deep Miller Class I or II gingival recessions compared to CTG alone with CAF. METHODS Seventy-two patients with Miller class I and II gingival recessions were enrolled. Thirty-six patients were randomly assigned to the test group [CAF+CTG+i-prf (700rpm for 3min)] or control group [CAF+CTG]. Clinical evaluations were made at 6 months. RESULTS At 6 months, complete root coverage was obtained at 88% of the sites treated with CAF+CTG+i-prf and 80% of the sites treated with CAF+CTG. Difference between the two groups was not statistically significant. At 6 months, the recession depth (RD) reduction and increase in keratinized tissue height (KTH) of the test sites were significantly better compared to the control sites. CONCLUSIONS According to the results, the addition of i-prf to the CAF+CTG treatment showed further development in terms of increasing the KTH and decreasing RD. However, this single trial is not sufficient to advocate the true clinical effect of i-prf on recession treatment with CAF+CTG and additional trials are needed.