Meconium Ileus

Abstract Cystic fibrosis is one of the most common inheritable traits in Caucasians. Meconium ileus and its potential complications are the most likely reasons that these patients will need surgical care. Surgical intervention is usually needed in the neonatal period but may also be required later in life. This article discusses the various ways cystic fibrosis can affect the gastrointestinal tract. Both the operative and nonoperative management of complicated and uncomplicated meconium ileus are discussed in the neonatal period as well as long-term issues, such as distal intestinal obstructive syndrome, fibrosing colonopathy, and rectal prolapse, all of which may be seen in older children and adults.

[1]  R. Kavanagh,et al.  Comparative Effectiveness of Imaging Modalities for the Diagnosis of Intestinal Obstruction in Neonates and Infants:: A Critically Appraised Topic. , 2016, Academic radiology.

[2]  P. Davis,et al.  Epidemiology of Cystic Fibrosis. , 2016, Clinics in chest medicine.

[3]  S. Stanojevic,et al.  A standardized approach to estimating survival statistics for population-based cystic fibrosis registry cohorts. , 2016, Journal of clinical epidemiology.

[4]  J. Tobias,et al.  Geographic variations in cystic fibrosis: An analysis of the U.S. CF Foundation Registry , 2015, Pediatric pulmonology.

[5]  R. Gibney,et al.  Cystic Fibrosis below the Diaphragm: Abdominal Findings in Adult Patients. , 2015, Radiographics : a review publication of the Radiological Society of North America, Inc.

[6]  D. Vilozni,et al.  Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis. , 2015, World journal of gastroenterology.

[7]  K. Southern,et al.  Gastrointestinal surgery in cystic fibrosis: a 20-year review. , 2014, Journal of pediatric surgery.

[8]  D. Borowitz,et al.  Intestinal complications of cystic fibrosis , 2013, Current opinion in pulmonary medicine.

[9]  F. Lorey,et al.  Birth prevalence of disorders detectable through newborn screening by race/ethnicity , 2012, Genetics in Medicine.

[10]  D. Borowitz,et al.  A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon. , 2012, Journal of pediatric surgery.

[11]  A. Couture,et al.  US assessment of neonatal bowel (necrotizing enterocolitis excluded) , 2012, Pediatric Radiology.

[12]  B. Assael,et al.  Absence of a gender gap in survival. An analysis of the Italian registry for cystic fibrosis in the paediatric age. , 2011, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

[13]  R. Houwen,et al.  Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation , 2011, Current gastroenterology reports.

[14]  A. Bush,et al.  Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis? , 2010, Pediatric pulmonology.

[15]  J. Dickinson,et al.  Dilated and Echogenic Fetal Bowel and Postnatal Outcomes: A Surgical Perspective. Case Series and Literature Review , 2010, European journal of pediatric surgery.

[16]  D. Vilozni,et al.  Meconium Ileus in Patients With Cystic Fibrosis Is Not a Risk Factor for Clinical Deterioration and Survival: The Israeli Multicenter Study , 2010, Journal of pediatric gastroenterology and nutrition.

[17]  R. Houwen,et al.  Defining DIOS and Constipation in Cystic Fibrosis With a Multicentre Study on the Incidence, Characteristics, and Treatment of DIOS , 2010, Journal of pediatric gastroenterology and nutrition.

[18]  M. Griese,et al.  Long‐term pulmonary outcome after meconium ileus in cystic fibrosis , 2009, Pediatric pulmonology.

[19]  J. Gustafson,et al.  Cystic Fibrosis , 2009, Journal of the Iowa Medical Society.

[20]  J. Morton,et al.  Distal Intestinal Obstruction Syndrome (DIOS) in Patients with Cystic Fibrosis After Lung Transplantation , 2009, Journal of Gastrointestinal Surgery.

[21]  D. Mela,et al.  Ileal brake: A sensible food target for appetite control. A review , 2008, Physiology & Behavior.

[22]  C. McCudden,et al.  Cystic fibrosis: newborn screening in America. , 2008, MLO: medical laboratory observer.

[23]  G. Rakoczy,et al.  Primary resection and anastomosis for complicated meconium ileus: a safe procedure? , 2007, Pediatric Surgery International.

[24]  Y. Aigrain,et al.  Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. , 2006, Journal of pediatric surgery.

[25]  G. Chaudry,et al.  Abdominal manifestations of cystic fibrosis in children , 2006, Pediatric Radiology.

[26]  S. Engum,et al.  Surgical considerations in cystic fibrosis: a 32-year evaluation of outcomes. , 2005, Surgery.

[27]  P. Farrell,et al.  Longitudinal pulmonary status of cystic fibrosis children with meconium ileus , 2004, Pediatric pulmonology.

[28]  P. Marteau,et al.  Distal intestinal obstruction syndrome in adults with cystic fibrosis. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[29]  M. Kosorok,et al.  Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis. , 2004, American journal of epidemiology.

[30]  P. Pencharz,et al.  Transition of care between paediatric and adult gastroenterology. Cystic fibrosis. , 2003, Best practice & research. Clinical gastroenterology.

[31]  D. Serban,et al.  Fibrosing colonopathy revealing cystic fibrosis in a neonate before any pancreatic enzyme supplementation. , 2002, Journal of pediatric gastroenterology and nutrition.

[32]  A. Deaton,et al.  T-tube ileostomy for meconium ileus: four decades of experience. , 2000, Journal of pediatric surgery.

[33]  R. Wyllie.  Gastrointestinal Manifestations of Cystic Fibrosis , 1999, Clinical pediatrics.

[34]  J. Andersen,et al.  Rectal Prolapse in Pediatrics , 1999, Clinical pediatrics.

[35]  P. Prescott,et al.  Patterns of use of pancreatic enzyme supplements in fibrosing colonopathy: implications for pathogenesis , 1997, Pharmacoepidemiology and drug safety.

[36]  J. Lloyd-Still,et al.  High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. , 1997, The New England journal of medicine.

[37]  B. Pawel,et al.  The pathology of fibrosing colonopathy of cystic fibrosis: a study of 12 cases and review of the literature. , 1997, Human pathology.

[38]  J. Littlewood.  Fibrosing colonopathy in children with cystic fibrosis. , 1996, Postgraduate medical journal.

[39]  B. Wilcken,et al.  Neonatal screening for cystic fibrosis: a comparison of two strategies for case detection in 1.2 million babies. , 1995, The Journal of pediatrics.

[40]  D. Ashby,et al.  Fibrosing colonopathy in cystic fibrosis: results of a case-control study , 1995, The Lancet.

[41]  W. Warwick,et al.  Cystic fibrosis-associated colitis and fibrosing colonopathy. , 1995, The Journal of pediatrics.

[42]  A. Smyth,et al.  Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes , 1994, The Lancet.

[43]  K. Conlon,et al.  Use of the appendix stump in the treatment of meconium ileus. , 1989, Journal of pediatric surgery.

[44]  E. Berman.  Gastrointestinal manifestations of cystic fibrosis , 1976 .

[45]  W. Pollock,et al.  MANAGEMENT OF COMPLICATED MECONIUM ILEUS. , 1964, American journal of surgery.

[46]  E. Sawicka,et al.  Meconium ileus in newborns with cystic fibrosis - results of treatment in the group of patients operated on in the years 2000-2014. , 2015, Developmental period medicine.

[47]  M. Manns,et al.  Transition of care between paediatric and adult gastroenterology. Autoimmune hepatitis. , 2003, Best practice & research. Clinical gastroenterology.

[48]  L. Tsui,et al.  Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. , 1989, Science.

[49]  T. Boat,et al.  Treatment and prognosis of rectal prolapse in cystic fibrosis. , 1982, Gastroenterology.

[50]  J. O'Neill,et al.  Surgical treatment of meconium ileus. , 1970, American journal of surgery.