Metabolic coordination of T cell quiescence and activation

[1]  A. Nenes.  RESPONSES , 2020, Jerusalem's Survival, Sennacherib's Departure, and the Kushite Role in 701 BCE.

[2]  J. Locasale,et al.  T cell stemness and dysfunction in tumors are triggered by a common mechanism , 2019, Science.

[3]  J. Kinet,et al.  Calcium signalling in T cells , 2019, Nature Reviews Immunology.

[4]  D. Rubinsztein,et al.  Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A , 2019, Cell metabolism.

[5]  R. Müller,et al.  The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling. , 2018, Cell metabolism.

[6]  J. Locasale,et al.  Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism , 2018, Cell.

[7]  R. Müller,et al.  The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling , 2018, Cell metabolism.

[8]  M. Mehta,et al.  Mitochondrial complex III is essential for regulatory T cell suppressive function , 2018, Nature.

[9]  Dirk Mossmann,et al.  mTOR signalling and cellular metabolism are mutual determinants in cancer , 2018, Nature Reviews Cancer.

[10]  Peter Vogel,et al.  Hippo Kinases Mst1 and Mst2 Sense and Amplify IL‐2R‐STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity , 2018, Immunity.

[11]  B. Garcia,et al.  Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals , 2018, Cell.

[12]  R. D. Hatton,et al.  Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells , 2018, Science.

[13]  Tingting Wang,et al.  Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation , 2018, eLife.

[14]  Y. Cong,et al.  Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis , 2018, Nature Communications.

[15]  Ajit S. Divakaruni,et al.  Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. , 2018, Cell metabolism.

[16]  P. Fink,et al.  Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8+ Recent Thymic Emigrants , 2018, The Journal of Immunology.

[17]  M. Birnbaum,et al.  Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development. , 2018, Immunity.

[18]  H. Chi,et al.  Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells , 2018, Science Immunology.

[19]  N. Shen,et al.  Iron Drives T Helper Cell Pathogenicity by Promoting RNA‐Binding Protein PCBP1‐Mediated Proinflammatory Cytokine Production , 2018, Immunity.

[20]  Jenna M. Sullivan,et al.  Maintenance of CD4 T cell fitness through regulation of Foxo1 , 2018, Nature Immunology.

[21]  Wei Xu,et al.  mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells , 2018, The Journal of Immunology.

[22]  A. Rudensky,et al.  Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border‐Dwelling Bacteria and Affect Physiologic Metabolite Balance , 2018, Immunity.

[23]  E. Hanse,et al.  The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells , 2018, Nature.

[24]  Haiyan Tan,et al.  Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells , 2018, Nature.

[25]  Nicole M. Chapman,et al.  mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis , 2018, Nature Communications.

[26]  Linda V. Sinclair,et al.  Single cell analysis of kynurenine and System L amino acid transport in T cells , 2018, Nature Communications.

[27]  Nicole M. Chapman,et al.  Hallmarks of T-cell Exit from Quiescence , 2018, Cancer Immunology Research.

[28]  E. Pearce,et al.  Unraveling the Complex Interplay Between T Cell Metabolism and Function. , 2018, Annual review of immunology.

[29]  Linda V. Sinclair,et al.  Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs , 2018, Science Signaling.

[30]  Lingyun Sun,et al.  T Cell Receptor‐Regulated TGF‐&bgr; Type I Receptor Expression Determines T Cell Quiescence and Activation , 2018, Immunity.

[31]  D. Martinvalet.  The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses , 2018, Cell Death & Disease.

[32]  Yingyu Chen,et al.  Newly Generated CD4+ T Cells Acquire Metabolic Quiescence after Thymic Egress , 2018, The Journal of Immunology.

[33]  Dimitri Krainc,et al.  Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis , 2018, Nature.

[34]  Amir Giladi,et al.  Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries , 2018, Cell.

[35]  D. M. Smith,et al.  Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis , 2017, Immunity.

[36]  K. Takeda,et al.  Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells. , 2017, Cell reports.

[37]  N. Perrimon,et al.  mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. , 2017, Cancer cell.

[38]  Joshua D. Rabinowitz,et al.  Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.

[39]  S. Feske,et al.  Store‐Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming , 2017, Immunity.

[40]  Joerg M. Buescher,et al.  Mitochondrial Priming by CD28 , 2017, Cell.

[41]  R. Myers,et al.  CCCTC‐Binding Factor Translates Interleukin 2‐ and &agr;‐Ketoglutarate‐Sensitive Metabolic Changes in T Cells into Context‐Dependent Gene Programs , 2017, Immunity.

[42]  Chuan Wu,et al.  Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signaling , 2017, Nature.

[43]  D. Wallace,et al.  Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. , 2017, Cell metabolism.

[44]  S. Dimauro,et al.  Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation. , 2017, Cell metabolism.

[45]  O. Elemento,et al.  Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival , 2017, Nature.

[46]  T. Mak,et al.  Glutathione Primes T Cell Metabolism for Inflammation , 2017, Immunity.

[47]  Haiyan Tan,et al.  Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation , 2017, Immunity.

[48]  P. Puigserver,et al.  Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism , 2017, Nature.

[49]  Takla Griss,et al.  Serine Is an Essential Metabolite for Effector T Cell Expansion. , 2017, Cell metabolism.

[50]  Takla Griss,et al.  Serine Is an Essential Metabolite for Effector T Cell Expansion. , 2017, Cell metabolism.

[51]  F. Issa.  Foxp3 and Toll-Like Receptor Signaling Balance Treg Cell Anabolic Metabolism for Suppression , 2017 .

[52]  M. Demetriou,et al.  Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation , 2016, eLife.

[53]  K. Yokote,et al.  Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells , 2016, Nature Communications.

[54]  A. Goldrath,et al.  Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection. , 2016, Immunity.

[55]  P. Hodgkin,et al.  A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses , 2016, Nature Immunology.

[56]  C. Leslie,et al.  Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism , 2016, Science.

[57]  J. Griffiths,et al.  The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate , 2016, Nature.

[58]  M. Warmoes,et al.  Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression , 2016, Nature Immunology.

[59]  M. Mann,et al.  L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity , 2016, Cell.

[60]  Scott A. Brown,et al.  mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. , 2016, Immunity.

[61]  P. Hawkins,et al.  Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells , 2016, Immunity.

[62]  Karen H. Vousden,et al.  Serine and one-carbon metabolism in cancer , 2016, Nature Reviews Cancer.

[63]  W. Linehan,et al.  Ionic immune suppression within the tumour microenvironment limits T cell effector function , 2016, Nature.

[64]  M. C. Archer,et al.  The interplay between cell signalling and the mevalonate pathway in cancer , 2016, Nature Reviews Cancer.

[65]  Y. Belkaid,et al.  Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche , 2016, Cell.

[66]  A. Rudensky,et al.  An essential role for IL-2 receptor in regulatory T cell function , 2016, Nature Immunology.

[67]  B. Skålhegg,et al.  T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions , 2016, PloS one.

[68]  Amy M Becker,et al.  Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. , 2016, Immunity.

[69]  Michal Sheffer,et al.  Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. , 2016, Cell metabolism.

[70]  T. Honjo,et al.  Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model , 2016, Proceedings of the National Academy of Sciences.

[71]  O. Kretz,et al.  Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.

[72]  Stephen L. Johnson,et al.  Lactate Metabolism is Associated with Mammalian Mitochondria , 2016, Nature chemical biology.

[73]  E. Ma,et al.  Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function. , 2016, Immunity.

[74]  L. Turka,et al.  Immunometabolism of regulatory T cells , 2016, Nature Immunology.

[75]  Mark M. Davis,et al.  Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol , 2016, Nature Immunology.

[76]  Linda V. Sinclair,et al.  Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy , 2016, Nature Immunology.

[77]  Xiaolong Liu,et al.  Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. , 2016, Cell reports.

[78]  Greg M. Delgoffe,et al.  Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8 T cell differentiation , 2016, Nature Immunology.

[79]  A. Rudensky,et al.  T cell receptor signalling in the control of regulatory T cell differentiation and function , 2016, Nature Reviews Immunology.

[80]  Wei Yang,et al.  Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism , 2016, Nature.

[81]  D. Green,et al.  Metabolic Maintenance of Cell Asymmetry following Division in Activated T Lymphocytes , 2016, Nature.

[82]  S. Manalis,et al.  Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. , 2016, Developmental cell.

[83]  Q. Sattentau,et al.  The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation , 2016, eLife.

[84]  J. Albeck,et al.  Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton , 2016, Cell.

[85]  A. Toure,et al.  Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity , 2016, Nature.

[86]  D. Green,et al.  Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis , 2015, Nature Immunology.

[87]  Ronald N. Germain,et al.  Immune homeostasis enforced by co-localized effector and regulatory T cells , 2015, Nature.

[88]  Toshiro K. Ohsumi,et al.  A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency , 2015, Nature Genetics.

[89]  A. Regev,et al.  CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity , 2015, Cell.

[90]  John P. Ray,et al.  The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. , 2015, Immunity.

[91]  R. Gold,et al.  Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. , 2015, Immunity.

[92]  Philippe A. Robert,et al.  Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation , 2015, Science Signaling.

[93]  V. De Rosa,et al.  Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants , 2015, Nature Immunology.

[94]  J. Locasale,et al.  Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses , 2015, Cell.

[95]  R. Schreiber,et al.  Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression , 2015, Cell.

[96]  J. Redondo,et al.  Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses. , 2015, Cell metabolism.

[97]  A. Rudensky,et al.  A Distinct Function of Regulatory T Cells in Tissue Protection , 2015, Cell.

[98]  K. Yokote,et al.  Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1. , 2015, Cell reports.

[99]  T. Ganz,et al.  Iron homeostasis in host defence and inflammation , 2015, Nature Reviews Immunology.

[100]  R. Flavell,et al.  Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells , 2015, Nature Immunology.

[101]  Linda V. Sinclair,et al.  Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes , 2015, The EMBO journal.

[102]  D. Sabatini,et al.  An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.

[103]  V. Kalia,et al.  Quiescence of Memory CD8(+) T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4. , 2015, Immunity.

[104]  G. Glick,et al.  Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism , 2015, The Journal of Immunology.

[105]  H. Virgin,et al.  Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation , 2015, The Journal of Immunology.

[106]  Robert A. Amezquita,et al.  IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity , 2015, Cell.

[107]  Greg M. Delgoffe,et al.  mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. , 2015, The Journal of clinical investigation.

[108]  G. Freeman,et al.  PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation , 2015, Nature Communications.

[109]  Julian C. Rayner,et al.  Post-translational protein modifications in malaria parasites , 2015, Nature Reviews Microbiology.

[110]  E. E. Vincent,et al.  The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. , 2015, Immunity.

[111]  H. Schild,et al.  Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo , 2015, Nature Immunology.

[112]  J. Locasale,et al.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. , 2015, The Journal of clinical investigation.

[113]  M. Carleton,et al.  Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. , 2014, Immunity.

[114]  G. Besra,et al.  Essential role for autophagy during invariant NKT cell development , 2014, Proceedings of the National Academy of Sciences.

[115]  R. Deberardinis,et al.  Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. , 2014, Molecular cell.

[116]  Hongbo Chi,et al.  Cutting Edge: Discrete Functions of mTOR Signaling in Invariant NKT Cell Development and NKT17 Fate Decision , 2014, The Journal of Immunology.

[117]  Nataliya Gorinski,et al.  De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells , 2014, Nature Medicine.

[118]  H. Chi,et al.  Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs , 2014, Proceedings of the National Academy of Sciences.

[119]  K. Oestreich,et al.  Bcl-6 directly represses the gene program of the glycolysis pathway , 2014, Nature Immunology.

[120]  P. Romero,et al.  Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function , 2014, The Journal of Immunology.

[121]  J. Rathmell,et al.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.

[122]  S. Kang,et al.  Short chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway , 2014, Mucosal Immunology.

[123]  N. Sonenberg,et al.  Translational control of immune responses: from transcripts to translatomes , 2014, Nature Immunology.

[124]  Jae-Hoon Chang,et al.  Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. , 2014, Immunity.

[125]  L. Molinero,et al.  Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells , 2014, Proceedings of the National Academy of Sciences.

[126]  M. Bevan,et al.  Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development , 2014, Proceedings of the National Academy of Sciences.

[127]  C. Benoist,et al.  Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. , 2014, Immunity.

[128]  D. Wiest,et al.  Enforcement of γδ-lineage commitment by the pre–T-cell receptor in precursors with weak γδ-TCR signals , 2014, Proceedings of the National Academy of Sciences.

[129]  Jimin Gao,et al.  Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell–Mediated Antitumor Immunity , 2014, The Journal of Immunology.

[130]  L. Cantley,et al.  Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.

[131]  D. Guertin,et al.  T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. , 2013, Immunity.

[132]  C. Elly,et al.  TSC1 regulates the balance between effector and regulatory T cells. , 2013, The Journal of clinical investigation.

[133]  A. Rudensky,et al.  Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation , 2013, Nature.

[134]  M. Tomita,et al.  Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells , 2013, Nature.

[135]  P. Muranski,et al.  Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. , 2013, The Journal of clinical investigation.

[136]  W. Shi,et al.  The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells , 2013, Nature Immunology.

[137]  B. Faubert,et al.  CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability , 2013, Proceedings of the National Academy of Sciences.

[138]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[139]  Peter Vogel,et al.  mTORC1 couples immune signals and metabolic programming to establish Treg cell function , 2013, Nature.

[140]  B. Faubert,et al.  Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.

[141]  Vrajesh V. Parekh,et al.  Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell–Specific Deletion of Vps34 , 2013, The Journal of Immunology.

[142]  T. Graeber,et al.  The sterol regulatory element binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity , 2013, Nature Immunology.

[143]  J. Licht,et al.  Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.

[144]  Linda V. Sinclair,et al.  Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation , 2013, Nature immunology.

[145]  A. Singer,et al.  IL-7 signaling must be intermittent, not continuous, during CD8 T cell homeostasis to promote cell survival instead of cell death , 2012, Nature Immunology.

[146]  S. Kaech,et al.  Transcriptional control of effector and memory CD8+ T cell differentiation , 2012, Nature Reviews Immunology.

[147]  S. Gygi,et al.  A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans , 2012, Science.

[148]  Claire F Pearson,et al.  Exogenous Amino Acids Are Essential for Interleukin-7 Induced CD8 T Cell Gowth , 2012, PloS one.

[149]  C. Benoist,et al.  PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells , 2012, Nature.

[150]  G. V. D. van der Windt,et al.  Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. , 2012, Immunity.

[151]  D. Green,et al.  The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. , 2011, Immunity.

[152]  F. Nichols,et al.  Peroxisome Proliferator-Activated Receptor γ Is Required for CD4+ T Cell-Mediated Lymphopenia-Associated Autoimmunity , 2011, The Journal of Immunology.

[153]  D. Douek,et al.  Second messenger role for Mg2+ revealed by human T-cell immunodeficiency , 2011, Nature.

[154]  D. Douek,et al.  Signaling role for Mg2+ revealed by immunodeficiency due to loss of MagT1 , 2011, Nature.

[155]  D. Green,et al.  HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells , 2011, The Journal of experimental medicine.

[156]  D. Green,et al.  Tuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function , 2011, Nature immunology.

[157]  Haikun Wang,et al.  Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells , 2011, Nature Immunology.

[158]  J. Sprent,et al.  Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells , 2011, Nature Immunology.

[159]  A. Rudensky,et al.  Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. , 2011, Immunity.

[160]  Francis J. Huber,et al.  Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. , 2011, Immunity.

[161]  K. Frauwirth,et al.  Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation , 2010, The Journal of Immunology.

[162]  W. Pear,et al.  Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. , 2010, The Journal of clinical investigation.

[163]  C. Spencer,et al.  Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. , 2010, Immunity.

[164]  J. Rathmell,et al.  IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo , 2010, The Journal of Immunology.

[165]  R. Xavier,et al.  Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 , 2009, Nature.

[166]  Kathy O. Lui,et al.  Infectious tolerance via the consumption of essential amino acids and mTOR signaling , 2009, Proceedings of the National Academy of Sciences.

[167]  Russell G. Jones,et al.  Enhancing CD8 T-cell memory by modulating fatty acid metabolism , 2009, Nature.

[168]  Justin R. Cross,et al.  ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.

[169]  R. Flavell,et al.  An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. , 2009, Immunity.

[170]  G. Koretzky,et al.  T cell activation. , 2009, Annual review of immunology.

[171]  Daniel R. Beisner,et al.  Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor , 2009, Nature Immunology.

[172]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[173]  J. Buer,et al.  Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels , 2008, Science Signaling.

[174]  Peter Tontonoz,et al.  LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response , 2008, Cell.

[175]  J. Rathmell,et al.  Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 , 2008, The Journal of Immunology.

[176]  J. Rathmell,et al.  IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. , 2008, Blood.

[177]  S. Strack,et al.  Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death , 2007, EMBO reports.

[178]  M. Seman,et al.  NAD+ Released during Inflammation Participates in T Cell Homeostasis by Inducing ART2-Mediated Death of Naive T Cells In Vivo1 , 2007, The Journal of Immunology.

[179]  S. Ward.  Faculty Opinions recommendation of Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. , 2006 .

[180]  L. Turka,et al.  Cutting Edge: T Cell Requirement for CD28 Costimulation Is Due to Negative Regulation of TCR Signals by PTEN1 , 2006, The Journal of Immunology.

[181]  Corey M. Carlson,et al.  Kruppel-like factor 2 regulates thymocyte and T-cell migration , 2006, Nature.

[182]  M. Ciofani,et al.  Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism , 2005, Nature Immunology.

[183]  M. Carleton,et al.  Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage , 2005 .

[184]  P. Love,et al.  TCR Signal Strength Influences αβ/γδ Lineage Fate , 2005 .

[185]  B. Baban,et al.  GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. , 2005, Immunity.

[186]  S. Hori,et al.  Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization , 2005, The Journal of experimental medicine.

[187]  T. Okazaki,et al.  Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 , 2005, Nature Immunology.

[188]  M. Farrar,et al.  Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells1 , 2004, The Journal of Immunology.

[189]  M. Seman,et al.  NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. , 2003, Immunity.

[190]  T. Malek,et al.  Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors1 , 2003, The Journal of Immunology.

[191]  G. Damonte,et al.  Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase , 2002, The Journal of experimental medicine.

[192]  C. Thompson,et al.  The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.

[193]  C. Thompson,et al.  IL-7 Enhances the Survival and Maintains the Size of Naive T Cells1 , 2001, The Journal of Immunology.

[194]  Naoto Hirano,et al.  Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells , 2001, Nature Immunology.

[195]  T. Sasaki,et al.  T cell-specific loss of Pten leads to defects in central and peripheral tolerance. , 2001, Immunity.

[196]  J. Dennis,et al.  Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation , 2001, Nature.

[197]  M. V. Vander Heiden,et al.  In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. , 2000, Molecular cell.

[198]  M. Davis,et al.  Altered T cell receptor ligands trigger a subset of early T cell signals. , 1996, Immunity.

[199]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[200]  J. Allison,et al.  CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation , 1995, The Journal of experimental medicine.

[201]  P. Linsley,et al.  CTLA-4 can function as a negative regulator of T cell activation. , 1994, Immunity.

[202]  C. Anastassopoulou,et al.  Pathogenicity , 1981 .

[203]  A. Chinnaiyan,et al.  iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. , 2018, The Journal of clinical investigation.

[204]  Markus Ollert,et al.  Glutathione Primes T Cell Metabolism for Inflammation. , 2017, Immunity.

[205]  J. Griffiths,et al.  S-2-hydroxyglutarate regulates CD 8 + T-lymphocyte fate , 2016 .

[206]  G. Tsokos,et al.  Protein phosphatase 2A is requisite for the function of regulatory T cells this access benefits you. Your story matters , 2016 .

[207]  J. Bluestone,et al.  The phosphatase PTEN-mediated control of PI-3 kinase in T regs cells maintains homeostasis and lineage stability , 2015 .

[208]  H. Clark,et al.  The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells , 2009, Nature Immunology.