Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets.

[1]  E. Cario.  Therapeutic impact of toll‐like receptors on inflammatory bowel diseases: A multiple‐edged sword , 2008, Inflammatory bowel diseases.

[2]  E. Ekblad,et al.  Vasoactive intestinal peptide rescues cultured rat myenteric neurons from lipopolysaccharide induced cell death , 2008, Regulatory Peptides.

[3]  A. Di Sabatino,et al.  Matrix metalloproteinase‐3 production by gut IgG plasma cells in chronic inflammatory bowel disease , 2008, Inflammatory bowel diseases.

[4]  Andrew S.C. Rice,et al.  Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy , 2007, PAIN®.

[5]  R. Sidman,et al.  TLR8: An Innate Immune Receptor in Brain, Neurons and Axons , 2007, Cell cycle.

[6]  R. Sidman,et al.  Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals , 2007, The Journal of Neuroscience.

[7]  D. Podolsky,et al.  Innate immunity in inflammatory bowel disease. , 2007, World journal of gastroenterology.

[8]  A. Kraneveld,et al.  Mast cells and nerves tickle in the tummy: implications for inflammatory bowel disease and irritable bowel syndrome. , 2007, Pharmacology & therapeutics.

[9]  Hosung Jung,et al.  Monocyte chemoattractant protein‐1 functions as a neuromodulator in dorsal root ganglia neurons , 2007, Journal of neurochemistry.

[10]  M. Guslandi.  Probiotic Agents in the Treatment of Irritable Bowel Syndrome , 2007, The Journal of international medical research.

[11]  E. Quigley.  Bacteria: a new player in gastrointestinal motility disorders--infections, bacterial overgrowth, and probiotics. , 2007, Gastroenterology clinics of North America.

[12]  M. Mattson,et al.  Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits , 2007, Proceedings of the National Academy of Sciences.

[13]  A. Anderson,et al.  Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF‐α , 2007, Journal of neurochemistry.

[14]  M. Sofroniew,et al.  Starring roles for astroglia in barrier pathologies of gut and brain , 2007, Laboratory Investigation.

[15]  L. Wallace,et al.  Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[16]  T. Hibi,et al.  Exclusive increase of CX3CR1+CD28−CD4+ T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes , 2007, Inflammatory bowel diseases.

[17]  J. Lillard,et al.  CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication. , 2007, Endocrine, metabolic & immune disorders drug targets.

[18]  Masahiko Watanabe,et al.  CD3 and Immunoglobulin G Fc Receptor Regulate Cerebellar Functions , 2007, Molecular and Cellular Biology.

[19]  S. Carding,et al.  Inflammatory bowel disease: cause and immunobiology , 2007, The Lancet.

[20]  R. Coffman,et al.  Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists , 2007, Nature Medicine.

[21]  M. Lenz,et al.  Axonal Growth Potential of Lumbar Dorsal Root Ganglion Neurons in an Organ Culture System: Response of Nerve Growth Factor-sensitive Neurons to Neuronal Injury and an Inflammatory Cytokine , 2007, Spine.

[22]  M. Geier,et al.  Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. , 2007, International journal of food microbiology.

[23]  Gerald Holtmann,et al.  Immune activation in patients with irritable bowel syndrome. , 2007, Gastroenterology.

[24]  Guo-qiang Lu,et al.  Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: Role of microglia , 2007, Neurochemistry International.

[25]  P. Monahan,et al.  Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors , 2007, Molecular pain.

[26]  K. Michelsen,et al.  Toll-like receptors and innate immunity in gut homeostasis and pathology , 2007, Current opinion in hematology.

[27]  Y. Yang,et al.  Alternation of substance P-containing neural pathways in a rat model of irritable bowel syndrome with rectal distension. , 2006, Chinese journal of digestive diseases.

[28]  R. LaMotte,et al.  MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. , 2006, Journal of neurophysiology.

[29]  A. Kraneveld,et al.  Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice. , 2006, European journal of pharmacology.

[30]  S. Collins,et al.  Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse , 2006, Gut.

[31]  J. Fox,et al.  Disruption of Tight Junctions and Induction of Proinflammatory Cytokine Responses in Colonic Epithelial Cells by Campylobacter jejuni , 2006, Infection and Immunity.

[32]  Andrea Rosario Beccari,et al.  ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets. , 2006, Pharmacology & therapeutics.

[33]  D. R. Linden,et al.  Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits , 2006, Autonomic Neuroscience.

[34]  C. Maggi,et al.  Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human , 2006, Autonomic Neuroscience.

[35]  J. Galmiche,et al.  Intestinal neuro-epithelial interactions modulate neuronal chemokines production. , 2006, Biochemical and biophysical research communications.

[36]  T. Jaskowski,et al.  Analysis of Serum Antibodies in Patients Suspected of Having Inflammatory Bowel Disease , 2006, Clinical and Vaccine Immunology.

[37]  A. Holstein,et al.  Autoantibody profiles in microscopic colitis , 2006, Journal of gastroenterology and hepatology.

[38]  R. Jancalek,et al.  Intra- and Extraneuronal Changes of Immunofluorescence Staining for TNF- and TNFR1 in the Dorsal Root Ganglia of Rat Peripheral Neuropathic Pain Models , 2006, Cellular and Molecular Neurobiology.

[39]  Sang-Heon Cho,et al.  Food intolerance and skin prick test in treated and untreated irritable bowel syndrome. , 2006, World journal of gastroenterology.

[40]  A. Kraneveld,et al.  Critical Role for Mast Cells in the Pathogenesis of 2,4-Dinitrobenzene-Induced Murine Colonic Hypersensitivity Reaction , 2006, The Journal of Immunology.

[41]  J. Weinstein,et al.  Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats , 2006, European Spine Journal.

[42]  N. Saadé,et al.  Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: role of the enteric nervous system, VIP, and nitric oxide. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[43]  Lin Chang.  Neuroendocrine and neuroimmune markers in IBS: pathophysiological role or epiphenomenon? , 2006, Gastroenterology.

[44]  P. Scully,et al.  Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? , 2006, Gastroenterology.

[45]  K. Hargreaves,et al.  Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection , 2006, Journal of dental research.

[46]  F. Cominelli,et al.  New Concepts in the Pathophysiology of Inflammatory Bowel Disease , 2005, Annals of Internal Medicine.

[47]  J. Galmiche,et al.  Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin‐8 secretion , 2005, Cellular microbiology.

[48]  C. Andry,et al.  NF-κB Activation Precedes Increases in mRNA Encoding Neurokinin-1 Receptor, Proinflammatory Cytokines, and Adhesion Molecules in Dextran Sulfate Sodium–Induced Colitis in Rats , 2005, Digestive Diseases and Sciences.

[49]  F. Mégret,et al.  Monique Lafon Producers of Beta Interferon Human Neurons to Become Strong Virus Infection Switches Tlr-3-positive , 2005 .

[50]  H. Blaszyk,et al.  Indiscriminate loss of myenteric neurones in the TNBS‐inflamed guinea‐pig distal colon , 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[51]  Xian Wang,et al.  CCL2 and CXCL1 trigger calcitonin gene‐related peptide release by exciting primary nociceptive neurons , 2005, Journal of neuroscience research.

[52]  A. Gasbarrini,et al.  Chemokines in inflammatory bowel disease , 2005, Journal of Clinical Pathology.

[53]  R. LaMotte,et al.  Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[54]  S. Targan,et al.  Defects in mucosal immunity leading to ulcerative colitis , 2005, Immunological reviews.

[55]  E. Quigley.  Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases? , 2005, Chinese journal of digestive diseases.

[56]  T. Matsuda,et al.  Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion , 2005, Autonomic Neuroscience.

[57]  A. Eschalier,et al.  Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. , 2005, Gastroenterology.

[58]  S. Smid,et al.  Impaired capsaicin and neurokinin‐evoked colonic motility in inflammatory bowel disease , 2005, Journal of gastroenterology and hepatology.

[59]  S. Hunt,et al.  The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation , 2005, Arthritis research & therapy.

[60]  M. Caterina,et al.  A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[61]  P. Ernfors,et al.  Attenuation of acute experimental colitis by preventing NPY Y1 receptor signaling. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[62]  J. Malagelada,et al.  Pathogenesis of irritable bowel syndrome: The mast cell connection , 2005, Scandinavian journal of gastroenterology.

[63]  K. Jacobson,et al.  Myenteric plexus injury and apoptosis in experimental colitis , 2005, Autonomic Neuroscience.

[64]  Jeom-Yong Kim,et al.  Increase in neurokinin-1 receptor-mediated colonic motor response in a rat model of irritable bowel syndrome. , 2005, World journal of gastroenterology.

[65]  F. Cominelli.  Cytokine-based therapies for Crohn's disease--new paradigms. , 2004, The New England journal of medicine.

[66]  M. Neurath,et al.  Anti-interleukin-12 antibody for active Crohn's disease. , 2004, The New England journal of medicine.

[67]  R. Caprilli,et al.  Efficacy of conventional immunosuppressive drugs in IBD. , 2004, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[68]  Yanzhang Li,et al.  Cell-Specific Expression and Lipopolysaccharide-Induced Regulation of Tumor Necrosis Factor α (TNFα) and TNF Receptors in Rat Dorsal Root Ganglion , 2004, The Journal of Neuroscience.

[69]  Y. Kuraishi,et al.  Expression of Fc epsilon receptor I on primary sensory neurons in mice , 2004, Neuroreport.

[70]  M. Davies,et al.  Elevated Vasoactive Intestinal Peptide Concentrations in Patients with Irritable Bowel Syndrome , 2004, Digestive Diseases and Sciences.

[71]  M. Caterina,et al.  Proinflammatory Chemokines, Such as C-C Chemokine Ligand 3, Desensitize μ-Opioid Receptors on Dorsal Root Ganglia Neurons1 , 2004, The Journal of Immunology.

[72]  G. Barbara,et al.  Diagnosis and therapy of irritable bowel syndrome , 2004, Alimentary pharmacology & therapeutics.

[73]  R. Myers,et al.  TNF-&agr; and TNF-&agr; Receptor Type 1 Upregulation in Glia and Neurons After Peripheral Nerve Injury: Studies in Murine DRG and Spinal Cord , 2004 .

[74]  M. Neunlist,et al.  The human enteric nervous system , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[75]  C. Maggi,et al.  Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome , 2004, British journal of pharmacology.

[76]  D. Santini,et al.  Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. , 2004, Gastroenterology.

[77]  Shao-heng He,et al.  IL-10 and its related cytokines for treatment of inflammatory bowel disease. , 2004, World journal of gastroenterology.

[78]  Y. Kuraishi,et al.  Direct action of immunoglobulin G on primary sensory neurons through Fc gamma receptor I , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[79]  K. Sharkey,et al.  Interleukin-1beta activates specific populations of enteric neurons and enteric glia in the guinea pig ileum and colon. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[80]  F. Cominelli,et al.  The Th1 immune pathway as a therapeutic target in Crohn's disease. , 2003, Current opinion in investigational drugs.

[81]  R. Spiller,et al.  Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome , 2003, American Journal of Gastroenterology.

[82]  G. Bouma,et al.  The immunological and genetic basis of inflammatory bowel disease , 2003, Nature Reviews Immunology.

[83]  V. Petrozza,et al.  Central effects of selective NK1 and NK3 tachykinin receptor agonists on two models of experimentally-induced colitis in rats , 2003, Peptides.

[84]  M. Delgado,et al.  Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease. , 2003, Gastroenterology.

[85]  L. Sorkin,et al.  Increased Sensitivity of Injured and Adjacent Uninjured Rat Primary Sensory Neurons to Exogenous Tumor Necrosis Factor-α after Spinal Nerve Ligation , 2003, The Journal of Neuroscience.

[86]  W. Sandborn.  Strategies for targeting tumour necrosis factor in IBD. , 2003, Best practice & research. Clinical gastroenterology.

[87]  J. Fozard,et al.  Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa , 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

[88]  Osamu Yoshie,et al.  Chemokine/chemokine receptor nomenclature. , 2003, Cytokine.

[89]  Penny A. Johnson,et al.  Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease , 2003, The Journal of pathology.

[90]  J. Galmiche,et al.  Changes in chemical coding of myenteric neurones in ulcerative colitis , 2003, Gut.

[91]  B. Nyberg,et al.  Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. , 2002, Gastroenterology.

[92]  S. Appel,et al.  Role of Fcγ Receptors in Nigral Cell Injury Induced by Parkinson Disease Immunoglobulin Injection into Mouse Substantia Nigra , 2002, Experimental Neurology.

[93]  L. Zou,et al.  Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin‐mediated calcium increase, and neurotransmitter release in motor neurons , 2002, Journal of neuroscience research.

[94]  J. Sanderson,et al.  Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis , 2002, Gut.

[95]  M. Walsh,et al.  Interactions between inflammatory cells and nerves. , 2002, Current opinion in pharmacology.

[96]  B. Guiard,et al.  Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. , 2002, Gastroenterology.

[97]  H. Eutamene,et al.  Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids , 2002, Gut.

[98]  Y. Ikeura,et al.  Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits. , 2002, The Journal of pharmacology and experimental therapeutics.

[99]  R. Myers,et al.  Anterograde TNFα transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve , 2002, Neuroscience Letters.

[100]  M. Swain,et al.  Role of chemokines and chemokine receptors in the gastrointestinal tract , 2002, Immunology.

[101]  E. Björnsson,et al.  Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors , 2002, American Journal of Gastroenterology.

[102]  H. Jerregård,et al.  Effects of IL-1beta, IL-6 or LIF on rat sensory neurons co-cultured with fibroblast-like cells. , 2002, Journal of neuroscience research.

[103]  U. Holzer‐Petsche,et al.  Tachykinin receptors in the gut: physiological and pathological implications. , 2001, Current opinion in pharmacology.

[104]  H. Natsugari,et al.  Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. , 2001, The Journal of pharmacology and experimental therapeutics.

[105]  R J Miller,et al.  Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons , 2001, The Journal of Neuroscience.

[106]  M. Neunlist,et al.  Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non‐inflamed rectum of patients with Crohn’s disease , 2001, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[107]  H. Nojima,et al.  Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. , 2001, Japanese Journal of Pharmacology.

[108]  J. Lopez-Garcia,et al.  Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors , 2001, Neuropharmacology.

[109]  R. Myers,et al.  Axonal transport of TNF-α in painful neuropathy: distribution of ligand tracer and TNF receptors , 2001, Journal of Neuroimmunology.

[110]  E. Bjornsson,et al.  An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome , 2001, Gut.

[111]  J. Becker,et al.  NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[112]  L. Lakatos.  Immunology of inflammatory bowel diseases. , 2000, Acta physiologica Hungarica.

[113]  F. Tonelli,et al.  Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. , 2000, The American journal of pathology.

[114]  M. Mori,et al.  Interleukin-8 and SDF1-α mRNA expression in colonic biopsies from patients with inflammatory bowel disease , 2000, American Journal of Gastroenterology.

[115]  Chih‐Yen Chen,et al.  Effect of a calcium channel blocker and antispasmodic in diarrhoea‐predominant irritable bowel syndrome , 2000, Journal of gastroenterology and hepatology.

[116]  Atsushi Mizoguchi,et al.  Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine1 , 2000, The Journal of Immunology.

[117]  M. Fukuzawa,et al.  Peptidergic nerves in the colon of patients with ulcerative colitis. , 2000, Hepato-gastroenterology.

[118]  C. Maggi,et al.  Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats , 2000, British journal of pharmacology.

[119]  M. Blennerhassett,et al.  Damage to the enteric nervous system in experimental colitis. , 1999, The American journal of pathology.

[120]  P. Andrews,et al.  Fundamentals of neurogastroenterology , 1999, Gut.

[121]  Hongzhen Hu,et al.  IL-1β and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system , 1999 .

[122]  G. Adler,et al.  Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury. , 1998, The Journal of pharmacology and experimental therapeutics.

[123]  F. Simons,et al.  A Mouse Model of Mosquito Allergy for Study of Antigen–Specific IgE and IgG Subclass Responses, Lymphocyte Proliferation, and IL–4 and IFN–Á Production , 1998, International Archives of Allergy and Immunology.

[124]  P. Holzer.  Implications of Tachykinins and Calcitonin Gene-Related Peptide in Inflammatory Bowel Disease , 1998, Digestion.

[125]  Miampamba,et al.  Distribution of calcitonin gene‐related peptide, somatostatin, substance P and vasoactive intestinal polypeptide in experimental colitis in rats , 1998, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[126]  B. Vainer,et al.  Expression of E-Selectin, Sialyl Lewis X, and Macrophage Inflammatory Protein-1α by Colonic Epithelial Cells in Ulcerative Colitis , 1998, Digestive Diseases and Sciences.

[127]  D. Thompson,et al.  Brain-gut axis in health and disease. , 1998, Gastroenterology.

[128]  J. Wallace,et al.  Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis , 1998, Regulatory Peptides.

[129]  P. Mantellini,et al.  Substance P and vasoactive intestinal polypeptide but not calcitonin gene-related peptide concentrations are reduced in patients with moderate and severe ulcerative colitis. , 1998, Italian journal of gastroenterology and hepatology.

[130]  R Wagner,et al.  Tumour necrosis factor-α induces ectopic activity in nociceptive primary afferent fibres , 1997, Neuroscience.

[131]  R. Stead,et al.  Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. , 1997, Neuroimmunomodulation.

[132]  J. Féher,et al.  Direct morphological evidence of neuroimmunomodulation in colonic mucosa of patients with Crohn's disease. , 1997, Neuroimmunomodulation.

[133]  R. Fisher,et al.  The irritable bowel syndrome. , 1997, The New England journal of medicine.

[134]  H. Ahlman,et al.  Influence of Topical Rectal Application of Drugs on Dextran Sulfate-Induced Colitis in Rats , 1997, Digestive Diseases and Sciences.

[135]  H. Nagura,et al.  Abnormal neuropeptide concentration in rectal mucosa of patients with inflammatory bowel disease , 1996, Journal of Gastroenterology.

[136]  J. Markenson,et al.  Mechanisms of chronic pain. , 1996, The American journal of medicine.

[137]  I. Forgacs,et al.  Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. , 1996, Gut.

[138]  R. Hart,et al.  Tumor necrosis factor‐α induces substance P in sympathetic ganglia through sequential induction of interleukin‐1 and leukemia inhibitory factor , 1995 .

[139]  S. Soinila,et al.  Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis , 1995, Digestive Diseases and Sciences.

[140]  C. Maggi,et al.  Role of tachykinins as excitatory mediators of NANC contraction in the circular muscle of rat small intestine. , 1995, Journal of autonomic pharmacology.

[141]  P. Mantyh,et al.  Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. , 1995, Gastroenterology.

[142]  G. Gasbarrini,et al.  Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients. , 1995, Scandinavian journal of gastroenterology.

[143]  A. Kraneveld,et al.  Delayed‐type hypersensitivity‐induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade , 1995, British journal of pharmacology.

[144]  M. Farthing.  Fortnightly Review: Irritable bowel, irritable body, or irritable brain? , 1995 .

[145]  K. Hopp,et al.  Expression of mRNA for vasoactive intestinal peptide in normal human colon and during inflammation , 1995, Molecular and Cellular Biochemistry.

[146]  H. Nagura,et al.  Changes in neuropeptide‐containing nerves in human colonic mucosa with inflammatory bowel disease , 1994, Pathology international.

[147]  J. Wallace,et al.  Beneficial effects of local or systemic lidocaine in experimental colitis. , 1994, The American journal of physiology.

[148]  S. Stryker,et al.  Acquired megacolon is associated with alteration of vasoactive intestinal peptide levels and acetylcholinesterase activity , 1993, Regulatory Peptides.

[149]  M. Kagnoff.  Immunology of the intestinal tract. , 1993, Gastroenterology.

[150]  K. Sharkey,et al.  Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol. , 1993, The American journal of physiology.

[151]  Roberts Me,et al.  Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. , 1993 .

[152]  K. Haruma,et al.  Changes of colonic vasoactive intestinal peptide and cholinergic activity in rats with chemical colitis , 1992, Digestive Diseases and Sciences.

[153]  K. Das,et al.  Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. , 1992, The American journal of gastroenterology.

[154]  C. Lunardi,et al.  Double‐blind cross‐over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[155]  I. Fahmy,et al.  Estimation of serum and tissue immunoglobulins level in some colonic disorders. , 1991, Journal of the Egyptian Society of Parasitology.

[156]  G. Mullin.  Food allergy and irritable bowel syndrome. , 1991, JAMA.

[157]  E. Guthrie,et al.  A controlled trial of psychological treatment for the irritable bowel syndrome. , 1991, Gastroenterology.

[158]  D. Rachmilewitz,et al.  Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation , 1989, Digestive Diseases and Sciences.

[159]  H. Cooke.  Role of the “little brain” in the gut in water and electrolyte homeostasis 1 , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[160]  J. Carney,et al.  Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases , 1987, Digestive Diseases and Sciences.

[161]  H. Appelman,et al.  Histopathology differentiates acute self-limited colitis from ulcerative colitis. , 1987, Gastroenterology.

[162]  H. Cooke.  Neurobiology of the intestinal mucosa. , 1986, Gastroenterology.

[163]  S. Felten,et al.  Noradrenergic and peptidergic innervation of lymphoid tissue. , 1985, Journal of immunology.

[164]  C. Roberts,et al.  FOOD HYPERSENSITIVITY AND IRRITABLE BOWEL SYNDROME , 1983, The Lancet.

[165]  Dockerty Mb,et al.  The myenteric plexus in regional enteritis: a study of the number of ganglion cells in the ileum in 24 cases. , 1955 .

[166]  Kernohan Jw,et al.  The myenteric plexus in chronic ulcerative colitis. , 1953 .

[167]  M. Osterman.  Immune Activation in Patients With Irritable Bowel Syndrome , 2008 .

[168]  F. Romagné.  Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors. , 2007, Drug discovery today.

[169]  F. Mégret,et al.  The innate immune facet of brain , 2007, Journal of Molecular Neuroscience.

[170]  Y. Taché,et al.  Fundamentals of neurogastroenterology: basic science. , 2006, Gastroenterology.

[171]  T. Halstensen,et al.  The B-cell system in inflammatory bowel disease. , 2006, Advances in experimental medicine and biology.

[172]  R JoséKlinger,et al.  Irritable Bowel Syndrome , 2006 .

[173]  C. Andry,et al.  NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats. , 2005, Digestive diseases and sciences.

[174]  T. Shimosegawa,et al.  Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? , 2005, Laboratory Investigation.

[175]  R. Myers,et al.  TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. , 2004, Spine.

[176]  Yanzhang Li,et al.  Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[177]  R. Myers,et al.  Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. , 2001, Journal of neuroimmunology.

[178]  A. Cohen,et al.  Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. , 2001, Gastroenterology.

[179]  T. Muto,et al.  Substance P containing nerve fibers in ulcerative colitis , 1998, International Journal of Colorectal Disease.

[180]  U. Holzer‐Petsche,et al.  Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation. , 1997, Pharmacology & therapeutics.

[181]  U. Holzer‐Petsche,et al.  Tachykinins in the gut. Part I. Expression, release and motor function. , 1997, Pharmacology & therapeutics.

[182]  L. Sorkin,et al.  Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. , 1997, Neuroscience.

[183]  V. Théodorou,et al.  Integrative neuroimmunology of the digestive tract. , 1996, Veterinary research.

[184]  R. Hart,et al.  Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. , 1995, Journal of neurobiology.

[185]  C. Maggi.  Tachykinins and Calcitonin Gene-Related Peptide , 1995 .

[186]  C. Bernstein,et al.  Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease. , 1993, The American journal of gastroenterology.

[187]  R. Farmer,et al.  Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease. , 1992, Gastroenterology.

[188]  S. Brookes,et al.  Chemical coding of neurons in the gastrointestinal tract. , 1991, Advances in experimental medicine and biology.

[189]  P. Mantyh,et al.  Alterations in receptors for sensory neuropeptides in human inflammatory bowel disease. , 1991, Advances in experimental medicine and biology.

[190]  E. Fehér,et al.  Ultrastructural changes in the nerve elements in Crohn's disease. , 1991, Acta chirurgica Hungarica.

[191]  M. Costa,et al.  Chemical coding of enteric neurons. , 1986, Progress in brain research.

[192]  J. Kernohan,et al.  The myenteric plexus in chronic ulcerative colitis. , 1953, Surgery, gynecology & obstetrics.