Immobilized cells : a review of recent literature

Abstract Advanced biocatalytic systems using immobilized cells have potential utility in various bioprocessing schemes and for biomedical and analytical purposes. Important advances continue to be made in the techniques of immobilization, the characterization of the resulting biocatalyst and potential applications. This review examines the recent literature in the area of cellular immobilization; it covers applications ranging from wastewater treatment to the production of therapeutics. New immobilization materials, several different bioreactor concepts and the properties of many specific systems are discussed. Anticipated future research trends are also outlined.

[1]  P. Galzy,et al.  Inulin hydrolysis by an immobilized yeast-cell reactor , 1983 .

[2]  H. Kuriyama,et al.  Continuous Ethanol Fermentation with Cell recycling using Flocculating Yeast , 1985 .

[3]  A. Daugulis,et al.  Filament formation and ethanol production by Zymomonas mobilis in adsorbed cell bioreactors , 1985, Biotechnology and bioengineering.

[4]  M. Goosen,et al.  Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas , 1985, Biotechnology and bioengineering.

[5]  J. Kennedy,et al.  Ethanol production from whey permeate by immobilized yeast cells , 1984 .

[6]  T. Tosa,et al.  Immobilized Living Microbial Cells , 1983 .

[7]  K. Luyben,et al.  Characterization of Nitrosomonas europaea immobilized in calcium alginate , 1983 .

[8]  J. Kennedy,et al.  Industrial Applications of Immobilized Cells , 1983 .

[9]  A. Margaritis,et al.  Effects of calcium chloride concentration on ethanol production and growth of immobilized Zymomonas mobilis , 1985 .

[10]  D. Giard,et al.  Serial propagation of mammalian cells on microcarriers , 1985, Biotechnology and bioengineering.

[11]  P. Linko,et al.  2,3‐Butanediol Production by Immobilized Cells of Enterobacter sp. a , 1984 .

[12]  J. Guthrie,et al.  The immobilization of enzymes and cells of Bacillus stearothermophilus onto poly(maleic anhydride/styrene)–Co‐polyethylene and poly(maleic anhydride/vinyl acetate)–Co‐polyethylene , 1985, Biotechnology and bioengineering.

[13]  M. Goosen,et al.  Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane. , 1984, Biochimica et biophysica acta.

[14]  J. Radovich.  Mass transfer effects in fermentations using immobilized whole cells , 1985 .

[15]  J. Klein,et al.  The Implication of Reaction Kinetics and Mass Transfer on the Design of Biocatalytic Processes with Immobilized Cells a , 1984 .

[16]  H. Blanch.  Immobilized Microbial Cells , 1984 .

[17]  W. J. Groot,et al.  Continuous isopropanol-butanol-ethanol fermentation by immobilized Clostridium beijerinckii cells in a packed bed fermenter , 1983 .

[18]  T. L. Donaldson,et al.  Biooxidation of coal gasification wastewaters , 1984 .

[19]  D. Hall,et al.  Photosynthetic production of fuels and chemicals in immobilized systems , 1984 .

[20]  I. Dunn,et al.  Biofilm Fluidized‐Bed Reactors and Their Application to Waste Water Nitrification , 1983 .

[21]  K. Nakanishi,et al.  Beer Brewing with Immobilized Yeast , 1985, Bio/Technology.

[22]  D. Bonham,et al.  Covalent coupling of microorganisms to a cellulosic support , 1985, Biotechnology and bioengineering.

[23]  P. Rouxhet,et al.  Immobilization of Yeast By Adhesion To a Support Without Use of a Chemical-agent , 1984 .

[24]  N. Stathopoulos,et al.  Shear stress effects on human embryonic kidney cells in Vitro , 1985, Biotechnology and bioengineering.

[25]  B. Hahn-Hägerdal,et al.  An enzyme coimmobilized with a microorganism: The conversion of cellobiose to ethanol using β‐glucosidase and Saccharomyces cerevisiae in calcium alginate gels , 1984, Biotechnology and bioengineering.

[26]  L. Noll,et al.  Ceramic Matrix for Large Scale Animal Cell Culture , 1985, Bio/Technology.

[27]  K. Luyben,et al.  Ethylene oxide production by immobilized Mycobacterium Py1 in a gas-solid bioreactor , 1983 .

[28]  Pekka Linko,et al.  Applications of Immobilized Lactic Acid Bacteria a , 1984 .

[29]  M. Turkina,et al.  Immobilization of living microbial cells and their application for steroid transformations , 1983 .

[30]  P. Hallenbeck.  Immobilized microorganisms for hydrogen and ammonia production , 1983 .

[31]  A. Klibanov.  Immobilized Enzymes and Cells as Practical Catalysts , 1983, Science.

[32]  M L Shuler,et al.  Continuous Immobilized Recombinant Protein Production from E. coli Capable of Selective Protein Excretion: A Feasibility Study , 1985, Biotechnology progress.

[33]  H. Pedersen,et al.  Immobilized plant cell reactors , 1983 .

[34]  P. Halling,et al.  The Potential in Biotechnology of Immobilized Cells and of Immobilized Multistep Enzyme-Coenzyme Systems [and Discussion] , 1983 .

[35]  T. Matsunaga,et al.  Regeneration of NAD(P)H by immobilized whole cells of Clostridium butyricum under hydrogen high pressure , 1985, Biotechnology and bioengineering.

[36]  P. Rouxhet,et al.  Immobilization of Saccharomyces cerevisiae by adhesion: Treatment of the cells by Al ions , 1985, Biotechnology and bioengineering.

[37]  G. Rechnitz,et al.  Cell-based biosensors , 1985 .

[38]  J Meier,et al.  A mechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers , 1985, Biotechnology and bioengineering.

[39]  T. Clark,et al.  Induced flocculation of Pachysolen tannophilus using the tower fermentor. , 1985, Biotechnology and bioengineering.

[40]  I. Karube,et al.  Large‐Scale Bacterial Fuel Cell Using Immobilized Photosynthetic Bacteria , 1984 .

[41]  P. Bajpai,et al.  Novel Immobilized‐Cell Systems for the Production of Ethanol from Jerusalem Artichoke , 1983 .

[42]  W. Hartmeier.  Immobilized biocatalysts — From simple to complex systems , 1985 .

[43]  T. H. Lee,et al.  Performance of an immobilized yeast reactor system for ethanol production , 1983 .

[44]  K. Kennedy,et al.  Stability and performance of mesophilic anaerobic fixed‐film reactors during organic overloading , 1985, Biotechnology and bioengineering.

[45]  A. Margaritis,et al.  Kinetics of ethanol production by immobilized cells of Zymomonas mobilis at varying D-glucose concentrations , 1985 .

[46]  A. Margaritis,et al.  Advances in ethanol production using immobilized cell systems , 1983 .

[47]  P. Bajpai,et al.  Improvement of inulinase stability of calcium alginate immobilized Kluyveromyces marxianus cells by treatment with hardening agents , 1985 .

[48]  B. Hahn-Hägerdal.  Comparison between immobilized Kluyveromyces fragilis and Saccharomyces cerevisiae coimmobilized with beta-galactosidase, with respect to continuous ethanol production from concentrated whey permeate. , 1985, Biotechnology and bioengineering.

[49]  A. Constantinides,et al.  Reproductive Immobilized Cells a , 1984 .

[50]  P. Wankat,et al.  An immobilized cell reactor with simultaneous product separation. I. Reactor design and analysis , 1985, Biotechnology and bioengineering.

[51]  E. Vandamme.  Peptide antibiotic production through immobilized biocatalyst technology , 1983 .

[52]  K. Vorlop,et al.  Immobilized Cells: Catalyst Preparation and Reaction Performance , 1983 .

[53]  M. Nagashima,et al.  Technology Developments in Biomass Alcohol Production in Japan: Continuous Alcohol Production with Immobilized Microbial Cells , 1983 .

[54]  C. Garrett,et al.  Isomaltulose production using immobilized cells , 1985, Biotechnology and bioengineering.

[55]  Application of Biosensor in Fermentation Processes , 1983 .

[56]  R. Colwell,et al.  Applications of Biotechnology to the Production, Recovery and Use of Marine Polysaccharides , 1985, Bio/Technology.

[57]  M. Shuler,et al.  Entrapped Plant Cell Tissue Cultures , 1983 .

[58]  P. Brodelius.  Production of Biochemicals with Immobilized Plant Cells: Possibilities and Problems , 1983 .

[59]  S. Reuveny,et al.  New Microcarriers for Culturing Mammalian Cells , 1983, Annals of the New York Academy of Sciences.

[60]  P. Rouxhet,et al.  Dehydrogenation of cortisol by Arthrobacter simplex immobilized as supported monolayer , 1984 .