The Many Faces of Tau

[1]  Charless C. Fowlkes,et al.  Alzheimer’s Disease Neuroimaging Initiative , 2005 .

[2]  R. Schirmer,et al.  “Lest we forget you — methylene blue …” , 2011, Neurobiology of Aging.

[3]  M. Kamboh,et al.  Emerging Histomorphologic Phenotypes of Chronic Traumatic Encephalopathy in American Athletes , 2011, Neurosurgery.

[4]  J. Trojanowski,et al.  The acetylation of tau inhibits its function and promotes pathological tau aggregation. , 2011, Nature communications.

[5]  Rudi D'Hooge,et al.  Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant , 2011, The Journal of Neuroscience.

[6]  Julie R. Leitz,et al.  Tau Protein Is Required for Amyloid β-Induced Impairment of Hippocampal Long-Term Potentiation , 2011, The Journal of Neuroscience.

[7]  E. Mandelkow,et al.  Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment , 2011, Neurobiology of Aging.

[8]  L. Mucke,et al.  Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[9]  K. Ashe,et al.  Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.

[10]  L. Buée,et al.  Nuclear Tau, a Key Player in Neuronal DNA Protection* , 2010, The Journal of Biological Chemistry.

[11]  Q. Tian,et al.  Essential role of tau phosphorylation in adult hippocampal neurogenesis , 2010, Hippocampus.

[12]  V. Haroutunian,et al.  Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy , 2010, Neuron.

[13]  Julie A. Harris,et al.  Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network , 2010, Neuron.

[14]  Jason E Gestwicki,et al.  Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden , 2010, Molecular Neurodegeneration.

[15]  Y. Jho,et al.  Monte carlo simulations of tau proteins: effect of phosphorylation. , 2010, Biophysical Journal.

[16]  Yadong Huang,et al.  Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice , 2010, The Journal of Neuroscience.

[17]  J. Trojanowski,et al.  Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy , 2010, The Journal of Neuroscience.

[18]  Kai Zhang,et al.  Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport , 2010, Science.

[19]  S. Maeda,et al.  Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss* , 2010, The Journal of Biological Chemistry.

[20]  S. Yen,et al.  Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy , 2010, Neuropathology and applied neurobiology.

[21]  E. Mandelkow,et al.  Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines , 2010, The Journal of Neuroscience.

[22]  A. Cuervo,et al.  Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation , 2010, Neurobiology of Disease.

[23]  D. Wilcock,et al.  Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease , 2010, Neuroscience.

[24]  Jürgen Götz,et al.  Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.

[25]  N. Grigoriadis,et al.  Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice , 2010, Experimental Neurology.

[26]  Sangmook Lee,et al.  Secretion of human tau fragments resembling CSF‐tau in Alzheimer's disease is modulated by the presence of the exon 2 insert , 2010, FEBS letters.

[27]  M. Hellerstein,et al.  Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice , 2010, Neuroscience.

[28]  K. Zahs,et al.  Probing the Biology of Alzheimer's Disease in Mice , 2010, Neuron.

[29]  J. Luebke,et al.  Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs , 2010, Experimental Neurology.

[30]  J. L. Cantero,et al.  Role of tau protein on neocortical and hippocampal oscillatory patterns , 2010, Hippocampus.

[31]  K. Blennow,et al.  CSF biomarkers predict a more malignant outcome in Alzheimer disease , 2010, Neurology.

[32]  C. Jack,et al.  Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects , 2010, Alzheimer's & Dementia.

[33]  Joseph V. Hajnal,et al.  A robust method to estimate the intracranial volume across MRI field strengths (1.5T and 3T) , 2010, NeuroImage.

[34]  D. Campion,et al.  Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein , 2010, Journal of Neurochemistry.

[35]  Gloria Lee,et al.  Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding* , 2010, The Journal of Biological Chemistry.

[36]  B. Hyman,et al.  Caspase activation precedes and leads to tangles , 2010, Nature.

[37]  T. Zako,et al.  Amyloid oligomers: formation and toxicity of Aβ oligomers , 2010, The FEBS journal.

[38]  M. Schumacher,et al.  A role for FKBP52 in Tau protein function , 2010, Proceedings of the National Academy of Sciences.

[39]  A. Sun,et al.  Deletion of tau attenuates heat shock‐induced injury in cultured cortical neurons , 2010, Journal of neuroscience research.

[40]  K. Herrup Faculty Opinions recommendation of Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. , 2009 .

[41]  R. Brandt,et al.  Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau , 2009, The Journal of Neuroscience.

[42]  R. He,et al.  The proline-rich domain of tau plays a role in interactions with actin , 2009, BMC Cell Biology.

[43]  E. Mandelkow,et al.  Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. , 2009, Human molecular genetics.

[44]  Gloria Lee,et al.  Microtubule‐associated protein tau in human prostate cancer cells: Isoforms, phosphorylation, and interactions , 2009, Journal of cellular biochemistry.

[45]  M. Blackledge,et al.  Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. , 2009, Biochemistry.

[46]  J. Bol,et al.  Transglutaminases and Transglutaminase‐Catalyzed Cross‐Links Colocalize with the Pathological Lesions in Alzheimer's Disease Brain , 2009, Brain Pathology.

[47]  Bruce H. Morimoto,et al.  Addressing Alzheimer's disease tangles: from NAP to AL-108. , 2009, Current Alzheimer research.

[48]  E. Sigurdsson Tau-focused immunotherapy for Alzheimer's disease and related tauopathies. , 2009, Current Alzheimer research.

[49]  B. Hyman,et al.  Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy , 2009, Journal of neuropathology and experimental neurology.

[50]  H. Möller,et al.  Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. , 2009, The Journal of clinical psychiatry.

[51]  Martin Beibel,et al.  Transmission and spreading of tauopathy in transgenic mouse brain , 2009, Nature Cell Biology.

[52]  Xiongwei Zhu,et al.  Tau – an inhibitor of deacetylase HDAC6 function , 2009, Journal of neurochemistry.

[53]  M. Diamond,et al.  Propagation of Tau Misfolding from the Outside to the Inside of a Cell* , 2009, Journal of Biological Chemistry.

[54]  Yi Li,et al.  Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases , 2009, Journal of neurochemistry.

[55]  A. Lieberman,et al.  Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. , 2009, Human molecular genetics.

[56]  G. Santpere,et al.  LRRK2 and neurodegeneration , 2009, Acta Neuropathologica.

[57]  P. L. Peng,et al.  Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity , 2008, Neuron.

[58]  S. Maeda,et al.  Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. , 2008, Current Alzheimer research.

[59]  E. Mandelkow,et al.  Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation* , 2008, Journal of Biological Chemistry.

[60]  A. Takashima,et al.  GSK-3β Is Required for Memory Reconsolidation in Adult Brain , 2008, PLoS ONE.

[61]  L. Mucke,et al.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease , 2008, Nature Neuroscience.

[62]  A. Lieberman,et al.  The pathogenesis of Niemann–Pick type C disease: a role for autophagy? , 2008, Expert Reviews in Molecular Medicine.

[63]  T. Gura Hope in Alzheimer's fight emerges from unexpected places , 2008, Nature Network Boston.

[64]  E. Bigio,et al.  Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers , 2008, Neurobiology of Aging.

[65]  R. Berry,et al.  A possible link between astrocyte activation and tau nitration in Alzheimer's disease , 2008, Neurobiology of Disease.

[66]  Shaomin Li,et al.  Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory , 2008, Nature Medicine.

[67]  M. Zvelebil,et al.  Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases* , 2008, Journal of Biological Chemistry.

[68]  D. Holtzman,et al.  Active and passive immunotherapy for neurodegenerative disorders. , 2008, Annual review of neuroscience.

[69]  A. Harada,et al.  Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. , 2008, Biochemical and Biophysical Research Communications - BBRC.

[70]  J. Ávila,et al.  Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells , 2008, Molecular and Cellular Neuroscience.

[71]  F. Gage,et al.  Mechanisms and Functional Implications of Adult Neurogenesis , 2008, Cell.

[72]  Ram Dixit,et al.  Differential Regulation of Dynein and Kinesin Motor Proteins by Tau , 2008, Science.

[73]  Aidong Yuan,et al.  Axonal Transport Rates In Vivo Are Unaffected by Tau Deletion or Overexpression in Mice , 2008, The Journal of Neuroscience.

[74]  H. Bujard,et al.  The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy , 2008, The Journal of Neuroscience.

[75]  J. Luchsinger,et al.  Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms , 2007, The Journal of Neuroscience.

[76]  D. Dias-Santagata,et al.  Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. , 2007, Molecular biology of the cell.

[77]  O. Touloumi,et al.  Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model , 2007, Journal of Pharmacology and Experimental Therapeutics.

[78]  S. Maeda,et al.  Molecular chaperone‐mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain , 2007, Journal of Neuroscience Research.

[79]  Ayodeji A. Asuni,et al.  Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements , 2007, The Journal of Neuroscience.

[80]  L. Mucke,et al.  Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models* , 2007, Journal of Biological Chemistry.

[81]  John Q Trojanowski,et al.  High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. , 2007, Biochemical and biophysical research communications.

[82]  L. Mucke,et al.  Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model , 2007, Science.

[83]  S. Maeda,et al.  Assembly of two distinct dimers and higher‐order oligomers from full‐length tau , 2007, The European journal of neuroscience.

[84]  K. Ashe,et al.  Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy , 2007, The Journal of Neuroscience.

[85]  Hyonchol Kim,et al.  Granular tau oligomers as intermediates of tau filaments. , 2007, Biochemistry.

[86]  G. Collingridge,et al.  LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β , 2007, Neuron.

[87]  K. Bhaskar,et al.  Tau impacts on growth-factor-stimulated actin remodeling , 2007, Journal of Cell Science.

[88]  Cam Patterson,et al.  The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. , 2007, The Journal of clinical investigation.

[89]  Tudor A. Fulga,et al.  Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo , 2007, Nature Cell Biology.

[90]  T. Arendt,et al.  Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus , 2007, Hippocampus.

[91]  Bin Zhang,et al.  Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.

[92]  G. Johnson,et al.  The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. , 2006, Current Alzheimer research.

[93]  A. Erisir,et al.  Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid , 2006, The Journal of cell biology.

[94]  M. Farrer,et al.  Parkinsonism, Lrrk2 G2019S, and tau neuropathology , 2006, Neurology.

[95]  J. Ávila,et al.  Extracellular tau is toxic to neuronal cells , 2006, FEBS letters.

[96]  I. Gozes,et al.  Peptide neuroprotection through specific interaction with brain tubulin , 2006, Journal of neurochemistry.

[97]  M. Rasenick,et al.  Tau associates with actin in differentiating PC12 cells , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[98]  T. Iwatsubo,et al.  P4-261 Small molecule inhibitors of alpha-synuclein filament assembly , 2006, Alzheimer's & Dementia.

[99]  Stefani N. Thomas,et al.  Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation* , 2006, Journal of Biological Chemistry.

[100]  T. Iwatsubo,et al.  Small Molecule Inhibitors of α-Synuclein Filament Assembly† , 2006 .

[101]  P. Fraser,et al.  Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein* , 2006, Journal of Biological Chemistry.

[102]  L. Qiang,et al.  Tau Protects Microtubules in the Axon from Severing by Katanin , 2006, The Journal of Neuroscience.

[103]  K. Gengyo-Ando,et al.  Progressive neurodegeneration in C. elegans model of tauopathy , 2005, Neurobiology of Disease.

[104]  S. Yen,et al.  Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau* , 2005, Journal of Biological Chemistry.

[105]  L. Mucke,et al.  Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[106]  Bin Zhang,et al.  Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial Tauopathies , 2005, The Journal of Neuroscience.

[107]  R. Takahashi,et al.  In vivo evidence of CHIP up‐regulation attenuating tau aggregation , 2005, Journal of neurochemistry.

[108]  D. Mann,et al.  Visualization of Newly Deposited tau in Neurofibrillary Tangles and Neuropil Threads , 2005, Journal of neuropathology and experimental neurology.

[109]  B. Hyman,et al.  Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.

[110]  Makoto Hashimoto,et al.  Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease , 2005, Neuron.

[111]  Roman Rouzier,et al.  Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[112]  Adriana B Ferreira,et al.  The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates β-Amyloid-Induced Neurodegeneration , 2005, The Journal of Neuroscience.

[113]  W. Noble,et al.  Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[114]  Takeshi Iwatsubo,et al.  Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins* , 2005, Journal of Biological Chemistry.

[115]  E. Mandelkow,et al.  Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells* , 2005, Journal of Biological Chemistry.

[116]  F. van Leuven,et al.  Changed Conformation of Mutant Tau-P301L Underlies the Moribund Tauopathy, Absent in Progressive, Nonlethal Axonopathy of Tau-4R/2N Transgenic Mice* , 2005, Journal of Biological Chemistry.

[117]  W. Albers,et al.  A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons , 2005, EMBO Journal.

[118]  Chi Li,et al.  Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[119]  Martin von Bergen,et al.  Tau aggregation is driven by a transition from random coil to beta sheet structure. , 2005, Biochimica et biophysica acta.

[120]  J. W. Rudy,et al.  Understanding contextual fear conditioning: insights from a two-process model , 2004, Neuroscience & Biobehavioral Reviews.

[121]  K. Nakayama,et al.  U‐box protein carboxyl terminus of Hsc70‐interacting protein (CHIP) mediates poly‐ubiquitylation preferentially on four‐repeat Tau and is involved in neurodegeneration of tauopathy , 2004, Journal of neurochemistry.

[122]  L. Petrucelli,et al.  P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation , 2004, Neurobiology of Aging.

[123]  P. Tittmann,et al.  Surface-decoration of microtubules by human tau. , 2004, Journal of molecular biology.

[124]  L. Mucke,et al.  Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice , 2004, The Journal of Neuroscience.

[125]  John Hardy,et al.  CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation , 2004 .

[126]  Tony Wyss-Coray,et al.  Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice , 2004, The Journal of Neuroscience.

[127]  G. V. Van Hoesen,et al.  Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease , 2004, The Journal of Neuroscience.

[128]  Steven P. Gygi,et al.  CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival* , 2004, Journal of Biological Chemistry.

[129]  K. Jellinger Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies , 2004, Neurology.

[130]  Wolfgang Härtig,et al.  Reversible Paired Helical Filament-Like Phosphorylation of Tau Is an Adaptive Process Associated with Neuronal Plasticity in Hibernating Animals , 2003, The Journal of Neuroscience.

[131]  R. Berry,et al.  Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[132]  Bin Zhang,et al.  Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[133]  C. Chirita,et al.  Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro* , 2003, Journal of Biological Chemistry.

[134]  J. Morrison,et al.  Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease , 2003, Neurology.

[135]  R. Nitsch,et al.  Proteasome inhibition by paired helical filament‐tau in brains of patients with Alzheimer's disease , 2003, Journal of neurochemistry.

[136]  M. Goedert,et al.  Repeat motifs of tau bind to the insides of microtubules in the absence of taxol , 2003, The EMBO journal.

[137]  T. Bird,et al.  Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles , 2002, Neurobiology of Disease.

[138]  S. Halpain,et al.  MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments , 2002, The Journal of cell biology.

[139]  M. Vitek,et al.  Tau is essential to β-amyloid-induced neurotoxicity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[140]  J. Trotter,et al.  Process Outgrowth of Oligodendrocytes Is Promoted by Interaction of Fyn Kinase with the Cytoskeletal Protein Tau , 2002, The Journal of Neuroscience.

[141]  E. Mandelkow,et al.  Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure* , 2001, The Journal of Biological Chemistry.

[142]  D. Mann,et al.  Amyloid β protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype , 2001, Neuroscience Letters.

[143]  M. Vitek,et al.  Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. , 2001, Journal of cell science.

[144]  Y. Ihara PHF and PHF-like fibrils –cause or consequence? , 2001, Neurobiology of Aging.

[145]  N. Hirokawa,et al.  Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes , 2000, The Journal of cell biology.

[146]  R. Brandt,et al.  Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical Filaments* , 2000, The Journal of Biological Chemistry.

[147]  K. Blennow,et al.  Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization , 2000, Neuroscience Letters.

[148]  N. Hirokawa,et al.  Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice , 2000, Neuroscience Letters.

[149]  R. Maccioni,et al.  Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death , 1999, FEBS letters.

[150]  G. Lynch,et al.  Lysosomal Protease Inhibitors Induce Meganeurites and Tangle-like Structures in Entorhinohippocampal Regions Vulnerable to Alzheimer's Disease , 1999, Experimental Neurology.

[151]  John X. Morris,et al.  Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. , 1998, Science.

[152]  M. Billingsley,et al.  Alterations in Tau Phosphorylation in Rat and Human Neocortical Brain Slices Following Hypoxia and Glucose Deprivation , 1998, Experimental Neurology.

[153]  E. Mandelkow,et al.  Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease , 1998, The Journal of cell biology.

[154]  H. Band,et al.  Tau interacts with src-family non-receptor tyrosine kinases. , 1998, Journal of cell science.

[155]  A. Andreadis,et al.  Splicing of a Regulated Exon Reveals Additional Complexity in the Axonal Microtubule‐Associated Protein Tau , 1998, Journal of neurochemistry.

[156]  S. Jenkins,et al.  Tau complexes with phospholipase C‐γ in situ , 1998 .

[157]  P. Janmey,et al.  The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau. , 1997, Biophysical journal.

[158]  T. Iwatsubo,et al.  Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex , 1997, Neuroreport.

[159]  J. Trojanowski,et al.  Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells) , 1997, The Journal of Neuroscience.

[160]  M. Bobinski,et al.  Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories , 1997, Neurobiology of Aging.

[161]  M. Ball,et al.  Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories: Concurrences and Cautions , 1997, Neurobiology of Aging.

[162]  E. Mandelkow,et al.  RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments , 1996, FEBS letters.

[163]  G. Hart,et al.  The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine* , 1996, The Journal of Biological Chemistry.

[164]  R. Crowther,et al.  Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans , 1996, Nature.

[165]  M. Roth,et al.  Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[166]  J. Mandell,et al.  A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons , 1996, The Journal of Neuroscience.

[167]  A. Faissner,et al.  Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner , 1996, The Journal of Neuroscience.

[168]  J. Ávila,et al.  Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction , 1996 .

[169]  Y. Ihara,et al.  τ Is Widely Expressed in Rat Tissues , 1996 .

[170]  S. Rhee,et al.  Activation of Phospholipase C-γ by the Concerted Action of Tau Proteins and Arachidonic Acid* , 1996, Journal of Biological Chemistry.

[171]  Alejandra del C. Alonso,et al.  Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules , 1996, Nature Medicine.

[172]  J. Troncoso,et al.  Differential Binding of Apolipoprotein E Isoforms to Tau and Other Cytoskeletal Proteins , 1996, Experimental Neurology.

[173]  G. Drewes,et al.  Structure, Microtubule Interactions, and Phosphorylation of Tau Protein a , 1996, Annals of the New York Academy of Sciences.

[174]  R. Brandt,et al.  Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain , 1995, The Journal of cell biology.

[175]  M. Shelanski,et al.  τ Regulation of Microtubule‐Microtubule Spacing and Bundling , 1994 .

[176]  M. Pericak-Vance,et al.  Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[177]  J. Trojanowski,et al.  Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau , 1994, Neuron.

[178]  J. Ávila,et al.  Analysis of microtubule-associated protein tau glycation in paired helical filaments. , 1994, The Journal of biological chemistry.

[179]  E. Mandelkow,et al.  Domains of tau protein and interactions with microtubules. , 1994, Biochemistry.

[180]  C. Surridge,et al.  The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau. , 1994, Biochemistry.

[181]  N. Hirokawa,et al.  Altered microtubule organization in small-calibre axons of mice lacking tau protein , 1994, Nature.

[182]  Khadija Iqbal,et al.  Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[183]  D. Graham,et al.  β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury , 1993, Neuroscience Letters.

[184]  Yasuo Ihara,et al.  Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments , 1993, Neuron.

[185]  E. Mandelkow,et al.  The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region. , 1992, The EMBO journal.

[186]  J. Trojanowski,et al.  A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.

[187]  R. A. Crowther,et al.  Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease , 1989, Neuron.

[188]  M. L. Schmidt,et al.  Distribution of tau proteins in the normal human central and peripheral nervous system. , 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[189]  M. Kirschner,et al.  The primary structure and heterogeneity of tau protein from mouse brain. , 1988, Science.

[190]  S. Mirra,et al.  Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[191]  H. Wiśniewski,et al.  Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.

[192]  Y. Ihara,et al.  One of the antigenic determinants of paired helical filaments is related to tau protein. , 1986, Journal of biochemistry.

[193]  E. Nishida,et al.  Calmodulin inhibits interaction of actin with MAP2 and Tau, two major microtubule-associated proteins. , 1985, Journal of Biological Chemistry.

[194]  M. Kirschner,et al.  Tubulin requires tau for growth onto microtubule initiating sites. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[195]  M. Kirschner,et al.  A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[196]  D. Selkoe Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[197]  J. Aubry,et al.  Lithium: Updated Human Knowledge Using an Evidence-Based Approach , 2009, CNS Drugs.

[198]  J. Aubry,et al.  Lithium: Updated Human Knowledge Using an Evidence-Based Approach , 2009, CNS drugs.

[199]  E. Sigurdsson Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. , 2008, Journal of Alzheimer's disease : JAD.

[200]  E. Bigio,et al.  Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. , 2008, Neurobiology of aging.

[201]  J. Trojanowski,et al.  Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease , 2004, Acta Neuropathologica.

[202]  R. Maccioni,et al.  Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies , 2002, Journal of cellular biochemistry.

[203]  J. Trojanowski,et al.  Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.

[204]  Y. Barde,et al.  Neurotrophins are required for nerve growth during development , 2001, Nature Neuroscience.

[205]  G. Johnson,et al.  Tau complexes with phospholipase C-gamma in situ. , 1998, Neuroreport.

[206]  J. Ávila,et al.  Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction. , 1996, Journal of neurochemistry.

[207]  Y. Ihara,et al.  Tau is widely expressed in rat tissues. , 1996, Journal of Neurochemistry.

[208]  M. Shelanski,et al.  tau Regulation of microtubule-microtubule spacing and bundling. , 1994, Journal of Neurochemistry.