Echocardiographic assessment of left ventricular hypertrophy and function in renal hypertensive dogs.

To investigate the performance of the hypertrophied left ventricle, M-mode echocardiographic measurements were performed 2 to 3 times weekly on 8 unanesthetized dogs for several weeks before and for 6 months after the induction of perinephritic hypertension. Four dogs with sham-wrapping and contralateral nephrectomy served as the controls. From a baseline value of 7.7 +/- 0.4 mm (mean +/- SD), left ventricular wall thickness increased to 9.0 +/- 0.6 mm (p less than 0.001) by the 4th week after the induction of hypertension and reached a plateau of 10.2 +/- 1.2 mm (p less than 0.001) by week 10. Fractional shortening of left ventricular dimension (% delta D) increased during early left ventricular hypertrophy and remained elevated for 6 months in the surviving 6 hypertensive dogs. In hypertensive dogs, left ventricular concentric hypertrophy became detectable by week 6 of hypertension. Control dogs did not show these changes. At autopsy, the left ventricular weight of hypertensive and normotensive control dogs was (6.2 +/- 1.4 g/kg and 4.3 +/- 0.5 g/kg (p less than 0.05). In summary, during the early stage of left ventricular hypertrophy in renal hypertensive dogs cardiac performance increased. There is no evidence for deterioration of left ventricular performance as concentric left ventricular hypertrophy develops and becomes chronic.

[1]  R. O'rourke,et al.  Left ventricular performance in patients with left ventricular hypertrophy caused by systemic arterial hypertension. , 1977, British heart journal.

[2]  M. Beznák.  Cardiac Output in Rats During the Development of Cardiac Hypertrophy , 1958, Circulation research.

[3]  A. DeMaria,et al.  Recommendations Regarding Quantitation in M-Mode Echocardiography: Results of a Survey of Echocardiographic Measurements , 1978, Circulation.

[4]  S. Sasayama,et al.  Contractile Performance of the Hypertrophied Ventricle in Patients with Systemic Hypertension , 1980, Circulation.

[5]  H. W. Overbeck,et al.  Mesenteric Hemodynamics in Early Experimental Renal Hypertension in Dogs , 1975, Circulation research.

[6]  F. Dunn,et al.  Pathophysiologic assessment of hypertensive heart disease with echocardiography. , 1977, The American journal of cardiology.

[7]  R. Tarazi,et al.  Cardiac pumping ability in rats with experimental renal and genetic hypertension. , 1979, The American journal of cardiology.

[8]  R. Tarazi,et al.  Cardiac Performance in Rats with Renal Hypertension , 1976, Circulation research.

[9]  M. Hallbäck-Nordlander,et al.  Hemodynamic consequences of left ventricular hypertrophy in spontaneously hypertensive rats. , 1979, American Journal of Cardiology.

[10]  J. Cohn,et al.  Hypertension and the heart. , 1974, Archives of Internal Medicine.

[11]  Meerson Fz.  The myocardium in hyperfunction, hypertrophy and heart failure. , 1969 .

[12]  S. Morioka,et al.  Echocardiographic evidence for early left ventricular hypertrophy in renal hypertensive dogs , 1981 .

[13]  R. Kerber,et al.  An animal model for experimental echocardiographic studies , 1976, Journal of clinical ultrasound : JCU.

[14]  M. Pfeffer,et al.  Pumping Ability of the Hypertrophying Left Ventricle of the Spontaneously Hypertensive Rat , 1976, Circulation research.

[15]  J. Cohn,et al.  Ventricular dimensions measured noninvasively by echocardiography in the awake dog. , 1976, Journal of applied physiology.

[16]  E. Frohlich,et al.  Clinical‐Physiological Correlations in the Development of Hypertensive Heart Disease , 1971, Circulation.

[17]  S. Ricksten,et al.  Performance of the hypertrophied left ventricle in spontaneously hypertensive rat. Effects of changes in preload and afterload. , 1979, Acta physiologica Scandinavica.

[18]  R Gorlin,et al.  Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. , 1976, The American journal of cardiology.