Altered Colchicine‐Binding Capacity in Chick Brain Regions: Relationship to Intensity or Information Content of Visual Input

Abstract: The binding of [3H]colchicine to postmitochondrial supernatant fractions of chick brain has been studied, absorbing colchicine‐bearing proteins on DEAE‐cellulose filter discs. This was assayed at several times after unilateral enucleation of day‐old chicks. Binding was unaltered in optic lobes or anterior dorsal forebrain regions contralateral to the removed eye, relative to the corresponding regions contralateral to and thus directly or secondarily innervated by the intact eye. Colchicine binding was also assayed after training chicks to suppress pecking at a metallic bead coated with aversive‐tasting methylanthranilate. At 4 but not 24 h after the one‐trial training, binding was selectively elevated in the anterior dorsal forebrain roof. Results are taken to imply that alterations in tubulin content of chick brain may reflect stress‐related changes, possibly mediated by systemic endocrine flux, rather than a more localized learning experience.

[1]  M. G. Gaston,et al.  Unilateral memory after binocular discrimination training: left hemisphere dominance in the chick? , 1984, Brain Research.

[2]  L. Rogers.  Light experience and asymmetry of brain function in chickens , 1982, Nature.

[3]  C. J. Denton.  Topography of the hyperstriatal visual projection area in the young domestic chicken , 1981, Experimental Neurology.

[4]  S. Rose,et al.  Ontogenetic and Imprinting‐Induced Changes in Chick Brain Protein Metabolism and Muscarinic Receptor Binding Activity , 1981, Journal of neurochemistry.

[5]  K. Ng,et al.  Engram duplication in the day-old chick. , 1981, Behavioral and neural biology.

[6]  S. Rose,et al.  First Exposure of Dark‐reared Rats Colchicine Binding Capacity of to Light Increases Visual Cortex , 1980 .

[7]  S. Rose,et al.  Increased Incorporation of [3H]Fucose into Chick Brain Glycoproteins Following Training on a Passive Avoidance Task , 1980, Journal of neurochemistry.

[8]  S. Rose,et al.  Passive Avoidance Learning Results in Region‐Specific Changes in Concentration of and Incorporation into Colchicine‐Binding Proteins in the Chick Forebrain , 1980, Journal of neurochemistry.

[9]  S. Rose,et al.  First exposure of dark-reared rats to light increases colchicine binding capacity of visual cortex. , 1980, Journal of Neurochemistry.

[10]  P. Bateson,et al.  An autoradiographic study of the chick brain after imprinting , 1979, Brain Research.

[11]  A. Lockwood.  Molecules in mammalian brain that interact with the colchicine site on tubulin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[12]  G. Horn,et al.  Neuronal plasticity in the chick brain: morphological effects of visual experience on neurones in hyperstriatum accessorium , 1979, Brain Research.

[13]  S. Rose,et al.  INCREASED BINDING OF [3H]COLCHICINE TO VISUAL CORTEX PROTEINS OF DARK‐REARED RATS ON FIRST EXPOSURE TO LIGHT , 1978, Journal of neurochemistry.

[14]  J. Cronly-Dillon,et al.  Tubulin synthesis during a critical period in visual cortex development , 1978, Brain Research.

[15]  M. Harrington,et al.  Brain blood flow: alteration by prior exposure to a learned task. , 1978, Science.

[16]  S. Rose,et al.  Synthesis of tubulin‐enriched fraction in rat visual cortex is modulated by dark‐rearing and light‐exposure , 1976, FEBS letters.

[17]  J. Cronly-Dillon,et al.  Tubulin synthesis in developing rat visual cortex , 1976, Nature.

[18]  S. Rose,et al.  Imprinting: Correlations between behaviour and incorporation of [14C]uracil into chick brain , 1975, Brain Research.

[19]  R. Lehman,et al.  Visual attention affects brain blood flow , 1974, Nature.

[20]  K. Nott.  Sensory deprivation and brain development. The avian visual system as a model , 1973 .

[21]  A. Owens,et al.  The binding of vincristine, vinblastine and colchicine to tubulin. , 1972, Biochemical and biophysical research communications.

[22]  W Hodos,et al.  Telencephalic projections of the nucleus rotundus in the pigeon (Columba livia) , 1970, The Journal of comparative neurology.

[23]  A. Cherkin.  Kinetics of memory consolidation: role of amnesic treatment parameters. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[24]  E. Taylor,et al.  The colchicine-binding protein of mammalian brain and its relation to microtubules. , 1968, Biochemistry.

[25]  M A Corner,et al.  Developmental patterns in the central nervous system of birds. I. Electrical activity in the cerebral hemisphere, optic lobe and cerebellum. , 1967, Progress in brain research.

[26]  W. Cowan,et al.  An experimental study of the avian visual system. , 1961, Journal of anatomy.